The Role of Genetic Factors in the Development of Individual Predisposition to Ischemic Stroke View Full Text


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Article Info

DATE

2017-12

AUTHORS

V. I. Korchagin, K. O. Mironov, O. P. Dribnokhodova, M. Yu. Maksimova, S. N. Illarioshkin, M. M. Tanashyan, A. E. Platonov, G. A. Shipulin, A. A. Raskurazhev, M. A. Piradov

ABSTRACT

Intensive development of DNA analysis technologies and large-scale genome-wide association studies have led to accumulation of a large array of data on the relationship between genetic factors and various phenotypic manifestations, including monogenic and polygenic hereditary diseases. This has greatly extended the capabilities of clinical diagnostics and predictive medicine in the field of socially significant diseases. For example, the role of a genetic component of the risk for such multifactorial and polyetiologic disease as stroke is now actively explored. Large-scale studies have revealed both general and specific genetic markers associated only with a certain type and subtype of stroke. This review analyzes the current state of the problem of using genetic markers for diagnosis of predisposition to stroke, complex issues associated with multiplicity of risk factors for stroke, and potential development in this area. More... »

PAGES

886-897

References to SciGraph publications

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  • 2012-05-04. The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls in MOLECULAR BIOLOGY REPORTS
  • 2006-03. Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2009-05-10. Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry in NATURE GENETICS
  • 2005-02. Genome-wide association studies: theoretical and practical concerns in NATURE REVIEWS GENETICS
  • 2012-09-02. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke in NATURE GENETICS
  • 2010-09-17. Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis in GENETICS IN MEDICINE
  • 2012-11-25. Quantitative assessment of the association between MTHFR C677T polymorphism and hemorrhagic stroke risk in MOLECULAR BIOLOGY REPORTS
  • 2010-08-23. Genetics of stroke in ACTA PHARMACOLOGICA SINICA
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  • 2014-06-22. Βeta-fibrinogen gene promoter A −455 allele associated with poor longterm survival among 55–71 years old Caucasian women in Finnish stroke cohort in BMC NEUROLOGY
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    URI

    http://scigraph.springernature.com/pub.10.1134/s0362119717080047

    DOI

    http://dx.doi.org/10.1134/s0362119717080047

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101358017


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