Methods of IR spectroscopy in monitoring of chemotherapy of oncological pathologies using palladium complexes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

G. B. Tolstorozhev, M. V. Bel’kov, I. V. Skornyakov, V. I. Pekhn’o, A. N. Kozachkova, N. V. Tsarik, I. P. Kutsenko, N. I. Sharykina

ABSTRACT

FTIR spectroscopy is used to study mammary-gland tissues of mice with a sarcoma tumor (strain 180). Spectral features that are typical of malignant tumors are revealed in the FTIR spectra in the sarcoma-tumor tissues. Tumor tissues are studied after treatment using coordination compounds based on palladium complexes with 3-amino-1-hydroxypropylidene-1,1-diphosphonic acid and zoledronic acid. A therapeutic effect is not revealed after treatment using palladium complex with 3-amino-1-hydroxypropylidene-1,1-diphosphonic acid. The suppression of tumor growth amounts to 59% when palladium complexes with zoledronic acid are used. Suppression of tumor growth is accompanied by variations in spectral characteristics. With respect to diagnostic features, the FTIR spectra of tumor tissues after treatment with the palladium complexes with zoledronic acid are similar to the FTIR spectra of tissues that are free of malignant tumors. Specific spectroscopic characteristics that make it possible to control the chemotherapy of oncological pathologies are determined. More... »

PAGES

850-854

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0030400x14110228

DOI

http://dx.doi.org/10.1134/s0030400x14110228

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006184814


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