Two-photon excited fluorescence of the lens for the diagnosis of presbyopia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

R. Steiner, M. Kessler, O. Fugger, F. Dolp, D. Russ

ABSTRACT

Presbyopia is a wide spread phenomenon in elder people and is caused by the hardening of the lens in human eyes. Research is performed to make such lenses again more flexible by application of geometrically optimised cuts through the lens with a femtosecond-laser. Different protein agglomerations are responsible for the flexibility reduction of the lens. Two-photon excited fluorescence of the lens can be used as a diagnostic tool to localise such protein accumulations. In in-vitro experiments with human cataract lenses and also lenses of the Philly-mouse it could be demonstrated that with age the fluorescence increases as presbyopia proceeds. The distribution of the fluorescing compounds are not homogeneous but rather cloudy. Discrimination of the compounds by fluorescence lifetime measurements in relation of the depth in the lens is possible. More... »

PAGES

469

Journal

TITLE

Optics and Spectroscopy

ISSUE

3

VOLUME

107

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0030400x09090276

DOI

http://dx.doi.org/10.1134/s0030400x09090276

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017489113


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