miRNA-16 as an Internal Control in Breast Cancer Studies: A Systematic Review and Meta-Analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-09-08

AUTHORS

H. N. N. Thu, H. T. N. Vy, T. N. N. Thanh, D. T. N. Giang, T. N. Nhan, N. P. Hoang, T. N. Hue

ABSTRACT

Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) is a method of choice for quantifying micro RNAs (miRNAs). Typically, RT-qPCR data are normalized to reference genes. While miRNAs are used for diagnosing and subtyping breast cancer, various studies show their deregulation in this condition, thus, undermining miRNAs’ utility as a reference. This review examines the expression pattern of miR-16 and suggests normalization approaches for breast cancer. We analyzed the data from selected peer-reviewed studies to calculate the standardized mean difference (SMD) with subsequent Chi-square testing and identified the difference in miR-16 expression between breast cancer patients and healthy controls. With a negative SMD value of ‒0.56 and Chi-square of 62.62 (p-value = 0.05), the deregulation of miR-16 in breast cancer was confirmed. High variance in the stability value (SV) of miR-16 expression levels confirmed its inappropriateness as a control gene in breast cancer. The combination of miR-16 and miR-425 was confirmed as an accurate endogenous control. More... »

PAGES

941-949

References to SciGraph publications

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  • 2015-10-17. A circulating miRNA signature as a diagnostic biomarker for non-invasive early detection of breast cancer in BREAST CANCER RESEARCH AND TREATMENT
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    http://scigraph.springernature.com/pub.10.1134/s0026893321050137

    DOI

    http://dx.doi.org/10.1134/s0026893321050137

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