Possible Role of Prep1 Homeodomain Transcription Factor in Cardiac Mesenchymal Stromal Cells View Full Text


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Article Info

DATE

2021-11

AUTHORS

Y. S. Stafeev, E. K. Shevchenko, M. A. Boldireva, D. N. Penkov

ABSTRACT

—Homeodomain transcription factors play a significant role in mesenchymal stromal cells (MSCs). Previously, the role of Meis1, Pbx1 and Prep1 proteins from the TALE (Three Amino acid Loop Extension) family in adipocytic and osteogenic differentiation of mouse mesenchymal stromal cells was established. In this work, using ChIP-seq and bioinformatic analysis we investigated the binding pattern of PREP1 with the genomic DNA of human heart MSCs, identified nearby genes, and analyzed their ontology. The target genes of the PREP1 factor in cardiac MSCs have been established. Based on the results, the possible involvement of transcription factor PREP1 in the direct reprogramming of fibroblasts into cardiomyocytes is discussed. More... »

PAGES

847-853

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0026893321050125

DOI

http://dx.doi.org/10.1134/s0026893321050125

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1143980404


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