Beta Amyloid, Tau Protein, and Neuroinflammation: An Attempt to Integrate Different Hypotheses of Alzheimer’s Disease Pathogenesis View Full Text


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Article Info

DATE

2021-09

AUTHORS

D. G. Garbuz, O. G. Zatsepina, M. B. Evgen’ev

ABSTRACT

Alzheimer’s disease (AD) is a neurodegenerative disease that inevitably results in dementia and death. Currently, there are no pathogenetically grounded methods for the prevention and treatment of AD, and all current treatment regimens are symptomatic and unable to significantly delay the development of dementia. The accumulation of β-amyloid peptide (Aβ), which is a spontaneous, aggregation-prone, and neurotoxic product of the processing of signaling protein APP (Amyloid Precursor Protein), in brain tissues, primarily in the hippocampus and the frontal cortex, was for a long time considered the main cause of neurodegenerative changes in AD. However, attempts to treat AD based on decreasing Aβ production and aggregation did not bring significant clinical results. More and more arguments are arising in favor of the fact that the overproduction of Aβ in most cases of AD is not the initial cause, but a concomitant event of pathological processes in the course of the development of sporadic AD. The concept of neuroinflammation has come to the fore, suggesting that inflammatory responses play the leading role in the initiation and development of AD, both in brain tissue and in the periphery. The hypothesis about the key role of neuroinflammation in the pathogenesis of AD opens up new opportunities in the search for ways to treat and prevent this socially significant disease. More... »

PAGES

670-682

References to SciGraph publications

  • 2020-11-04. Are infections seeding some cases of Alzheimer’s disease? in NATURE
  • 2012-05. Proteinopathies, neurodegenerative disorders with protein aggregation-based pathology in MOLECULAR BIOLOGY
  • 2008-08-29. Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation in JOURNAL OF NEUROINFLAMMATION
  • 2015-09-09. Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy in NATURE
  • 2015-01-07. The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease in MOLECULAR NEUROBIOLOGY
  • 2016-06-14. Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function in SCIENTIFIC REPORTS
  • 2019-11. The Convergence of Alzheimer’s Disease Pathogenesis Concepts in MOLECULAR BIOLOGY
  • 2018-01-08. Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2015-05-26. Three dimensions of the amyloid hypothesis: time, space and 'wingmen' in NATURE NEUROSCIENCE
  • 2017-05. Transmission of pathogenic protein aggregates in Alzheimer’s disease in MOLECULAR BIOLOGY
  • 2015-05-20. Immune attack: the role of inflammation in Alzheimer disease in NATURE REVIEWS NEUROSCIENCE
  • 2011-08-16. Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels in CELL STRESS AND CHAPERONES
  • 2015-02-17. Innate immunity in Alzheimer's disease in NATURE IMMUNOLOGY
  • 2015-05-26. The case for rejecting the amyloid cascade hypothesis in NATURE NEUROSCIENCE
  • 2008-05-29. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease in JOURNAL OF NEUROINFLAMMATION
  • 2019-03-13. Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer’s disease? in JOURNAL OF NEUROVIROLOGY
  • 1995-06. Hypomethylation of the amyloid precursor protein gene in the brain of an alzheimer’s disease patient in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2007. NSAIDs for the Chemoprevention of Alzheimer’s Disease in INFLAMMATION IN THE PATHOGENESIS OF CHRONIC DISEASES
  • 2013-05-14. Peripherally Applied Synthetic Peptide isoAsp7-Aβ(1-42) Triggers Cerebral β-Amyloidosis in NEUROTOXICITY RESEARCH
  • 2015-10-21. Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation in SCIENTIFIC REPORTS
  • 1997-07. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity in NATURE
  • 2014-09-11. Heat shock proteins in neurodegenerative disorders and aging in JOURNAL OF CELL COMMUNICATION AND SIGNALING
  • 2015-03-24. Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes in MOLECULAR BRAIN
  • 2005-06-15. Traumatic brain injury: cause or risk of Alzheimer’s disease? A review of experimental studies in JOURNAL OF NEURAL TRANSMISSION
  • 2019-05-15. Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease in VIROLOGICA SINICA
  • 2012-04-19. Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer’s, but not in frontotemporal dementia in JOURNAL OF NEURAL TRANSMISSION
  • 2013-11-28. Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 on human neuronal cells in CELL DEATH & DISEASE
  • 2017-03-31. Not just amyloid: physiological functions of the amyloid precursor protein family in NATURE REVIEWS NEUROSCIENCE
  • 2016-05-27. AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo in SCIENTIFIC REPORTS
  • 2015-04-17. Rodent models of neuroinflammation for Alzheimer’s disease in JOURNAL OF NEUROINFLAMMATION
  • 2007-02. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-07-19. Drug candidates in clinical trials for Alzheimer’s disease in JOURNAL OF BIOMEDICAL SCIENCE
  • 2000-06. Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease: A Review in NEUROPSYCHOLOGY REVIEW
  • 2006. Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats in CELL STRESS AND CHAPERONES
  • 2016-08-11. Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models in NATURE COMMUNICATIONS
  • 2012-07-11. A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline in NATURE
  • 2020-12-14. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? in NATURE REVIEWS NEUROLOGY
  • 2018-12-13. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone in NATURE
  • 2018-02-15. Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery in ACTA NEUROPATHOLOGICA
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    http://scigraph.springernature.com/pub.10.1134/s002689332104004x

    DOI

    http://dx.doi.org/10.1134/s002689332104004x

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