Replication-competent gamma-retrovirus Mo-MuLV expressing green fluorescent protein as efficient tool for screening of inhibitors of retroviruses that use heparan sulfate ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05

AUTHORS

O. A. Stepanov, M. M. Prokof’eva, K. Stocking, V. P. Varlamov, A. N. Levov, G. A. Vikhoreva, P. V. Spirin, S. N. Mikhailov, V. S. Prassolov

ABSTRACT

The effect of sulfated polysaccharides on the efficiency of the infection of mouse transplantable fibroblast SC-1 and NIH-3T3 cell lines by replication-competent recombinant Moloney murine leukemia virus (Mo-MuLV), which carries the eGFP gene, was investigated. It was found that sulfated polysaccharides have no cytostatic and cytotoxic effects on SC-1 and NIH-3T3 cells in the concentration range of 0.01–100 μg/mL and have virucidal activity against Mo-MuLV. Polysaccharides in the indicated concentrations inhibit Mo-MuLV infection that prevents the further development of viral infection. It was shown that sulfated polysaccharides are also effective inhibitors of other retroviruses, including lentiviruses, which use sulfated polysaccharides as primary cell receptors. More... »

PAGES

457-466

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0026893312030119

DOI

http://dx.doi.org/10.1134/s0026893312030119

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030396476


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