The Mechanism of Antibacterial Action of the Lantibiotic Warnerin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-03-28

AUTHORS

V. P. Korobov, L. M. Lemkina, T. V. Polyudova

ABSTRACT

Evidence of membranotropic activity of the lantibiotic warnerin was obtained for warnerin-sensitive bacteria Staphylococcus cohnii VKM-3165. Warnerin attack led to increased bacterial respiratory activity and accumulation of reactive oxygen species resulting in the death of staphylococci. Warnerin caused dissipation of the transmembrane potential with release of potassium ions and ATP from the cells. Dissipation of the potential resulted in activation of bacterial autolysis, which depends on the value of the electrical component of the membrane potential. ΔΨ dissipation in the presence of valinomycin, a potassium transporter, almost neutralized the activation of the peptidoglycan hydrolase complex by warnerin. Electron microscopy of bacterial internal structure and scanning of the surface of warnerin-attacked cells of S. cohnii VKM-3165 confirmed the depth and irreversibility of warnerin action. More... »

PAGES

184-191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0026261722020059

DOI

http://dx.doi.org/10.1134/s0026261722020059

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146629950


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