Ontology type: schema:ScholarlyArticle
2022-03-28
AUTHORSV. P. Korobov, L. M. Lemkina, T. V. Polyudova
ABSTRACTEvidence of membranotropic activity of the lantibiotic warnerin was obtained for warnerin-sensitive bacteria Staphylococcus cohnii VKM-3165. Warnerin attack led to increased bacterial respiratory activity and accumulation of reactive oxygen species resulting in the death of staphylococci. Warnerin caused dissipation of the transmembrane potential with release of potassium ions and ATP from the cells. Dissipation of the potential resulted in activation of bacterial autolysis, which depends on the value of the electrical component of the membrane potential. ΔΨ dissipation in the presence of valinomycin, a potassium transporter, almost neutralized the activation of the peptidoglycan hydrolase complex by warnerin. Electron microscopy of bacterial internal structure and scanning of the surface of warnerin-attacked cells of S. cohnii VKM-3165 confirmed the depth and irreversibility of warnerin action. More... »
PAGES184-191
http://scigraph.springernature.com/pub.10.1134/s0026261722020059
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