HCV coinfection of the HIV-infected patients with discordant CD4+ T-cell response to antiretroviral therapy leads to intense systemic inflammation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

K. V. Shmagel, L. B. Korolevskaya, E. V. Saidakova, N. G. Shmagel, V. A. Chereshnev, L. Margolis, D. Anthony, M. Lederman

ABSTRACT

The level of proinflammatory markers was assessed in HIV-infected patients that were coinfected with hepatitis C virus (HCV) and had failed to restore the CD4+ T cell counts (immunological nonresponders, INR) during the antiretroviral therapy (ART). Among four patient groups (HIV+HCV- and HIV+HCV+ subjects with the concordant response to ART; HIV+HCV- and HIV+HCV+ subjects that were INR), the greatest systemic inflammation was in the latter group. The maximum difference was between the subjects HIV+HCV-INR and HIV+HCV+ INR: the blood of coinfected patients contained significantly higher concentrations of the IP-10, sCD163, sTNF-RI, and sTNF-RII and of bacterial lipopolysaccharide. Systemic inflammation in HIV/HCV coinfected patients with the discordant response to ART is probably caused by a breach of hepatic barrier for the intestine products. More... »

PAGES

244-247

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0012496617060047

DOI

http://dx.doi.org/10.1134/s0012496617060047

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100160043

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29299802


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