CD8+ T cell expansion in HIV/HCV coinfection is associated with systemic inflammation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05

AUTHORS

E. V. Saidakova, K. V. Shmagel, L. B. Korolevskaya, N. G. Shmagel, V. A. Chereshnev

ABSTRACT

High prevalence of non-AIDS-defining illnesses in treated HIV-infected patients is associated with increased peripheral CD8+ T cell counts. Hepatitis C virus (HCV) coinfection is an additional risk factor for the development of non-AIDS events. We found that, in HIV/HCV coinfection, the increased proportion of CD8+ T lymphocytes is due to the effector memory and terminal effector T cells gain. Moreover, in these patients, the accumulation of highly differentiated forms of CD8+ T lymphocytes was associated with increased concentrations of inflammatory indices. More... »

PAGES

126-128

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0012496617030024

DOI

http://dx.doi.org/10.1134/s0012496617030024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090607159

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28702728


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