The effects of afterload and stimulation delay on the slow force response in the heterogeneous myocardium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-09

AUTHORS

A. G. Kursanov, R. V. Lisin, S. Yu. Khamzin, A. A. Balakin, Yu. L. Protsenko, O. E. Solovyova

ABSTRACT

The results of numerical simulations and physiological experiments that assessed the dependence of the intramyocardial slow force response under an afterload in the heterogeneous myocardium are described. Muscle duplexes of our design were used as the simplest experimental and theoretical models of the heterogeneous myocardium. It is shown that the degree of the slow force response increases with an afterload and the time of the stimulation delay between the elements of the duplex. This effect is explainable by an increase in the time of the mechanical interaction between the duplex elements in the isometric phase of contraction. This leads to changes in individual contractility, the configuration of the action potential, and the kinetic characteristics of intracellular calcium in cardiomyocytes of interacting muscles. More... »

PAGES

759-764

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006350916050171

DOI

http://dx.doi.org/10.1134/s0006350916050171

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035209934


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ural Federal University", 
          "id": "https://www.grid.ac/institutes/grid.412761.7", 
          "name": [
            "Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia", 
            "Yeltsin Ural Federal University, ul. Mira 19, 620002, Yekaterinburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kursanov", 
        "givenName": "A. G.", 
        "id": "sg:person.0771546730.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771546730.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Immunology and Physiology", 
          "id": "https://www.grid.ac/institutes/grid.473278.d", 
          "name": [
            "Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lisin", 
        "givenName": "R. V.", 
        "id": "sg:person.0733241420.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733241420.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ural Federal University", 
          "id": "https://www.grid.ac/institutes/grid.412761.7", 
          "name": [
            "Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia", 
            "Yeltsin Ural Federal University, ul. Mira 19, 620002, Yekaterinburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khamzin", 
        "givenName": "S. Yu.", 
        "id": "sg:person.014053700057.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014053700057.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Immunology and Physiology", 
          "id": "https://www.grid.ac/institutes/grid.473278.d", 
          "name": [
            "Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balakin", 
        "givenName": "A. A.", 
        "id": "sg:person.0762501322.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762501322.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Immunology and Physiology", 
          "id": "https://www.grid.ac/institutes/grid.473278.d", 
          "name": [
            "Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Protsenko", 
        "givenName": "Yu. L.", 
        "id": "sg:person.013475145731.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013475145731.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Mathematics and Mechanics", 
          "id": "https://www.grid.ac/institutes/grid.465287.a", 
          "name": [
            "Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia", 
            "Yeltsin Ural Federal University, ul. Mira 19, 620002, Yekaterinburg, Russia", 
            "Institute of Mathematics and Mechanics, Ural Branch, Russian Academy of Sciences, ul. Sof\u2019i Kovalevskoi 16, 620990, Yekaterinburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solovyova", 
        "givenName": "O. E.", 
        "id": "sg:person.01304206260.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304206260.68"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pbiomolbio.2014.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004139593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1998.431bw.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004666276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00370248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010376975", 
          "https://doi.org/10.1007/bf00370248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/expphysiol.2003.026732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027815854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4236/jbise.2015.89060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028504558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00306.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034342644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00592656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042188433", 
          "https://doi.org/10.1007/bf00592656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00592656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042188433", 
          "https://doi.org/10.1007/bf00592656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2005.08.073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046037177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pbiomolbio.2012.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047408576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1142/s0218127403008983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062954178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1973.224.5.1195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080537162"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-09", 
    "datePublishedReg": "2016-09-01", 
    "description": "The results of numerical simulations and physiological experiments that assessed the dependence of the intramyocardial slow force response under an afterload in the heterogeneous myocardium are described. Muscle duplexes of our design were used as the simplest experimental and theoretical models of the heterogeneous myocardium. It is shown that the degree of the slow force response increases with an afterload and the time of the stimulation delay between the elements of the duplex. This effect is explainable by an increase in the time of the mechanical interaction between the duplex elements in the isometric phase of contraction. This leads to changes in individual contractility, the configuration of the action potential, and the kinetic characteristics of intracellular calcium in cardiomyocytes of interacting muscles.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1134/s0006350916050171", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017924", 
        "issn": [
          "0006-3509", 
          "1555-6654"
        ], 
        "name": "Biophysics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "61"
      }
    ], 
    "name": "The effects of afterload and stimulation delay on the slow force response in the heterogeneous myocardium", 
    "pagination": "759-764", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a7b97417687e3690e455d9244595004a22bb90f3fac7115ff5990e30ea596775"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1134/s0006350916050171"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035209934"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1134/s0006350916050171", 
      "https://app.dimensions.ai/details/publication/pub.1035209934"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88247_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1134%2FS0006350916050171"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1134/s0006350916050171'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1134/s0006350916050171'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1134/s0006350916050171'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1134/s0006350916050171'


 

This table displays all metadata directly associated to this object as RDF triples.

140 TRIPLES      21 PREDICATES      38 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1134/s0006350916050171 schema:about anzsrc-for:11
2 anzsrc-for:1116
3 schema:author N43473393379c45cebde7c62530e993e2
4 schema:citation sg:pub.10.1007/bf00370248
5 sg:pub.10.1007/bf00592656
6 https://doi.org/10.1016/j.jacc.2005.08.073
7 https://doi.org/10.1016/j.pbiomolbio.2012.08.011
8 https://doi.org/10.1016/j.pbiomolbio.2014.07.010
9 https://doi.org/10.1111/j.1469-7793.1998.431bw.x
10 https://doi.org/10.1113/expphysiol.2003.026732
11 https://doi.org/10.1142/s0218127403008983
12 https://doi.org/10.1152/ajpheart.00306.2005
13 https://doi.org/10.1152/ajplegacy.1973.224.5.1195
14 https://doi.org/10.4236/jbise.2015.89060
15 schema:datePublished 2016-09
16 schema:datePublishedReg 2016-09-01
17 schema:description The results of numerical simulations and physiological experiments that assessed the dependence of the intramyocardial slow force response under an afterload in the heterogeneous myocardium are described. Muscle duplexes of our design were used as the simplest experimental and theoretical models of the heterogeneous myocardium. It is shown that the degree of the slow force response increases with an afterload and the time of the stimulation delay between the elements of the duplex. This effect is explainable by an increase in the time of the mechanical interaction between the duplex elements in the isometric phase of contraction. This leads to changes in individual contractility, the configuration of the action potential, and the kinetic characteristics of intracellular calcium in cardiomyocytes of interacting muscles.
18 schema:genre research_article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N3c18654cabee41a8a864f71c304ccf86
22 N55258c167aba4ac791c83d4e6c6b2337
23 sg:journal.1017924
24 schema:name The effects of afterload and stimulation delay on the slow force response in the heterogeneous myocardium
25 schema:pagination 759-764
26 schema:productId N05feb9095c274a7186dd42fd3e7b4f0c
27 N712533010e204fd29cd334d911c314ff
28 N80d761abb1944127b107580995977b8f
29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035209934
30 https://doi.org/10.1134/s0006350916050171
31 schema:sdDatePublished 2019-04-11T13:10
32 schema:sdLicense https://scigraph.springernature.com/explorer/license/
33 schema:sdPublisher Ncaf755288d3e448e9634dc9fbbf61300
34 schema:url https://link.springer.com/10.1134%2FS0006350916050171
35 sgo:license sg:explorer/license/
36 sgo:sdDataset articles
37 rdf:type schema:ScholarlyArticle
38 N04307f032bb941d18d5296c8e8a03e73 rdf:first sg:person.014053700057.00
39 rdf:rest N0b683264a6ff415a8ce937892c2eac08
40 N05feb9095c274a7186dd42fd3e7b4f0c schema:name readcube_id
41 schema:value a7b97417687e3690e455d9244595004a22bb90f3fac7115ff5990e30ea596775
42 rdf:type schema:PropertyValue
43 N0b683264a6ff415a8ce937892c2eac08 rdf:first sg:person.0762501322.78
44 rdf:rest Nbbfa0eaf7f1d4232b40be4c68f3d0688
45 N3c18654cabee41a8a864f71c304ccf86 schema:volumeNumber 61
46 rdf:type schema:PublicationVolume
47 N43473393379c45cebde7c62530e993e2 rdf:first sg:person.0771546730.99
48 rdf:rest N7e099730019f4206922d3fe7a52ac3af
49 N55258c167aba4ac791c83d4e6c6b2337 schema:issueNumber 5
50 rdf:type schema:PublicationIssue
51 N712533010e204fd29cd334d911c314ff schema:name dimensions_id
52 schema:value pub.1035209934
53 rdf:type schema:PropertyValue
54 N7e099730019f4206922d3fe7a52ac3af rdf:first sg:person.0733241420.64
55 rdf:rest N04307f032bb941d18d5296c8e8a03e73
56 N80d761abb1944127b107580995977b8f schema:name doi
57 schema:value 10.1134/s0006350916050171
58 rdf:type schema:PropertyValue
59 Nbbfa0eaf7f1d4232b40be4c68f3d0688 rdf:first sg:person.013475145731.45
60 rdf:rest Ncd028188dcab49c1b1a7cc4f35be5052
61 Ncaf755288d3e448e9634dc9fbbf61300 schema:name Springer Nature - SN SciGraph project
62 rdf:type schema:Organization
63 Ncd028188dcab49c1b1a7cc4f35be5052 rdf:first sg:person.01304206260.68
64 rdf:rest rdf:nil
65 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
66 schema:name Medical and Health Sciences
67 rdf:type schema:DefinedTerm
68 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
69 schema:name Medical Physiology
70 rdf:type schema:DefinedTerm
71 sg:journal.1017924 schema:issn 0006-3509
72 1555-6654
73 schema:name Biophysics
74 rdf:type schema:Periodical
75 sg:person.01304206260.68 schema:affiliation https://www.grid.ac/institutes/grid.465287.a
76 schema:familyName Solovyova
77 schema:givenName O. E.
78 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304206260.68
79 rdf:type schema:Person
80 sg:person.013475145731.45 schema:affiliation https://www.grid.ac/institutes/grid.473278.d
81 schema:familyName Protsenko
82 schema:givenName Yu. L.
83 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013475145731.45
84 rdf:type schema:Person
85 sg:person.014053700057.00 schema:affiliation https://www.grid.ac/institutes/grid.412761.7
86 schema:familyName Khamzin
87 schema:givenName S. Yu.
88 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014053700057.00
89 rdf:type schema:Person
90 sg:person.0733241420.64 schema:affiliation https://www.grid.ac/institutes/grid.473278.d
91 schema:familyName Lisin
92 schema:givenName R. V.
93 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733241420.64
94 rdf:type schema:Person
95 sg:person.0762501322.78 schema:affiliation https://www.grid.ac/institutes/grid.473278.d
96 schema:familyName Balakin
97 schema:givenName A. A.
98 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762501322.78
99 rdf:type schema:Person
100 sg:person.0771546730.99 schema:affiliation https://www.grid.ac/institutes/grid.412761.7
101 schema:familyName Kursanov
102 schema:givenName A. G.
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771546730.99
104 rdf:type schema:Person
105 sg:pub.10.1007/bf00370248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010376975
106 https://doi.org/10.1007/bf00370248
107 rdf:type schema:CreativeWork
108 sg:pub.10.1007/bf00592656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042188433
109 https://doi.org/10.1007/bf00592656
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1016/j.jacc.2005.08.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046037177
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1016/j.pbiomolbio.2012.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047408576
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1016/j.pbiomolbio.2014.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004139593
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1111/j.1469-7793.1998.431bw.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004666276
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1113/expphysiol.2003.026732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027815854
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1142/s0218127403008983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062954178
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1152/ajpheart.00306.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034342644
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1152/ajplegacy.1973.224.5.1195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080537162
126 rdf:type schema:CreativeWork
127 https://doi.org/10.4236/jbise.2015.89060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028504558
128 rdf:type schema:CreativeWork
129 https://www.grid.ac/institutes/grid.412761.7 schema:alternateName Ural Federal University
130 schema:name Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia
131 Yeltsin Ural Federal University, ul. Mira 19, 620002, Yekaterinburg, Russia
132 rdf:type schema:Organization
133 https://www.grid.ac/institutes/grid.465287.a schema:alternateName Institute of Mathematics and Mechanics
134 schema:name Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia
135 Institute of Mathematics and Mechanics, Ural Branch, Russian Academy of Sciences, ul. Sof’i Kovalevskoi 16, 620990, Yekaterinburg, Russia
136 Yeltsin Ural Federal University, ul. Mira 19, 620002, Yekaterinburg, Russia
137 rdf:type schema:Organization
138 https://www.grid.ac/institutes/grid.473278.d schema:alternateName Institute of Immunology and Physiology
139 schema:name Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, 620041, Yekaterinburg, Russia
140 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...