Cooperativity in mechano-calcium feedbacks in the myocardium: Some conceptual discrepancies and overcoming inconsistency within the framework of a mathematical model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-09

AUTHORS

A. D. Dokuchaev, E. V. Shikhaleva, T. B. Sulman, N. A. Vikulova, L. V. Nikitina, L. B. Katsnelson

ABSTRACT

Mechano-calcium feedbacks that provide fine tuning of electrical and calcium activation of the heart muscle to mechanical conditions of contractions are an important element of electromechanical coupling as a key mechanism of the autoregulation of the contractile activity of the myocardium. A large quantity of experimental and theoretical evidence supports the cooperative dependence of the calcium-troponin complex kinetics on the cross-bridge concentration as a principal mechanism that underlies the mechano-calcium feedback in the intact myocardium. At the same time, experiments performed using skinned myocardial preparations have demonstrated that mechanical conditions significantly affected only the calcium sensitivity of the Ca2+–force relationship rather than its Hill coefficient of cooperativity. These data make some investigators doubt the contribution of cooperativity to the mechano-calcium feedbacks. To overcome these arising discrepancies, we propose an improved conception of cooperativity that reveals the extent of intensity differently in the steady state and in transitional processes. The proposed conception enables us to reproduce and explain both the mechanodependence of calcium activation in the intact myocardium and the results with skinned muscle within the framework of a mathematical model. More... »

PAGES

765-775

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006350916050043

DOI

http://dx.doi.org/10.1134/s0006350916050043

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019094817


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