The temperature effect on cardiac ryanodine receptor gating and conductance: Mathematical modeling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

A. S. Moskvin, B. I. Iaparov, A. M. Ryvkin, O. E. Solovyova

ABSTRACT

The temperature effect on cardiac ryanodine receptor (RyR) function has been studied within the electron-conformational (EC) model. It’s shown that a simple EC model with an Arrhenius-like temperature dependence of the “internal” and “external” frictions and a specific thermosensitivity of the tunnelling “open↔closed” transitions can provide both qualitative and quantitative description of the temperature effects for isolated RyRs. The potential of the model was illustrated by explaining the experimental data on the temperature dependence of isolated sheep cardiac RyR gating and conductance (R. Sitsapesan et al., J. Physiol. 434, 469(1991)). More... »

PAGES

614-621

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006350916040175

DOI

http://dx.doi.org/10.1134/s0006350916040175

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037294533


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