The action of androgens on Na+,K+-ATPase activity of erythrocyte membranes View Full Text


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Article Info

DATE

2014-01

AUTHORS

L. E. Panin, P. V. Mokrushnikov

ABSTRACT

The effect of androgens (testosterone, androsterone, dehydroepiandrosterone and dehydroepiandrosterone sulfate) on erythrocyte membrane during their nonspecific binding was investigated. The change in erythrocyte membrane Na+,K+-ATPase activity was measured at different hormone concentration in a suspension. It is shown that the dependence has dome-shaped character: at the elevated hormone concentration Na+,K+-ATPase activity starts to increase, reaches its maximum, and then decreases. The hypothesis is put forward that an increase in microscopists of erythrocyte membrane first intensifies Na+,K+-ATPase activity due to the growth of the maximum energy of membrane phonons, and then decreases it due to hindering conformational transitions in the enzyme molecule. More... »

PAGES

98-104

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006350914010138

DOI

http://dx.doi.org/10.1134/s0006350914010138

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015657347


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