A Platform for Studying Neurodegeneration Mechanisms Using Genetically Encoded Biosensors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

E. I. Ustyantseva, S. P. Medvedev, A. S. Vetchinova, J. M. Minina, S. N. Illarioshkin, S. M. Zakian

ABSTRACT

Patient-specific induced pluripotent stem cells (iPSCs) capable of differentiation into required cell type are a promising model for studying various pathological processes and development of new therapeutic approaches. However, no conventional strategies for using iPSCs in disease research have been established yet. Genetically encoded biosensors can be used for monitoring messenger molecules, metabolites, and enzyme activity in real time with the following conversion of the registered signals in quantitative data, thus allowing evaluation of the impact of certain molecules on pathology development. In this article, we describe the development of a universal cell-based platform for studying pathological processes associated with amyotrophic lateral sclerosis. For this purpose, we have created a series of plasmid constructs for monitoring endoplasmic reticulum stress, oxidative stress, apoptosis, and Ca2+-dependent hyperexcitability and generated transgenic iPSC line carrying mutation in the superoxide dismutase 1 gene (SOD1) and healthy control cell line. Both cell lines have specific transactivator sequence required for doxycycline-controlled transcriptional activation and can be used for a single-step biosensor insertion. More... »

PAGES

299-309

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s000629791903012x

DOI

http://dx.doi.org/10.1134/s000629791903012x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113042099


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