Development of Hematopoietic Stem Cells in the Early Mammalian Embryo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

S. A. Rybtsov, M. A. Lagarkova

ABSTRACT

Hematopoietic stem cells (HSCs) were the first stem cells discovered in humans. A. A. Maximov proposed an idea of blood stem cells that was confirmed later by McCulloch and Till experimentally. HSCs were the first type of stem cells to be used in clinics and ever since are being continually used. Indeed, a single HSC transplanted intravenously is capable of giving rise to all types of blood cells. In recent decades, human and animal HSC origin, development, hierarchy, and gene signature have been extensively investigated. Due to the constant need for donor blood and HSCs suitable for therapeutic transplants, the experimental possibility of obtaining HSCs in vitro by directed differentiation of pluripotent stem cells (PSCs) has been considered in recent years. However, despite all efforts, it is not yet possible to reproduce in vitro the ontogenesis of HSCs and obtain cells capable of long-term maintenance of hematopoiesis. The study of hematopoiesis in embryonic development facilitates the establishment and improvement of protocols for deriving blood cells from PCSs and allows a better understanding of the pathogenesis of various types of proliferative blood diseases, anemia, and immunodeficiency. This review focuses on the development of hematopoiesis in mammalian ontogenesis. More... »

PAGES

190-204

References to SciGraph publications

  • 2017-12. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice in NATURE COMMUNICATIONS
  • 2009-02. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter in NATURE
  • 2007-10. Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling in NATURE IMMUNOLOGY
  • 2016-07. Resolving early mesoderm diversification through single-cell expression profiling in NATURE
  • 2018-06. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche in NATURE MEDICINE
  • 2018-06. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche in NATURE
  • 2006-02. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells in NATURE MEDICINE
  • 2016-11. Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros in NATURE BIOTECHNOLOGY
  • 2010-10. Spotlight series on stem cell mobilization: many hands on the ball, but who is the quarterback? in LEUKEMIA
  • 1963-02. Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells in NATURE
  • 2016-03-08. Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells in NATURE COMMUNICATIONS
  • 2017-01. A view of human haematopoietic development from the Petri dish in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-01-25. Endothelial and perivascular cells maintain haematopoietic stem cells in NATURE
  • 1993-07. An early pre-liver intraembryonic source of CFU-S in the developing mouse in NATURE
  • 1995-02. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL in NATURE
  • 2008-03. Haematopoietic stem cell release is regulated by circadian oscillations in NATURE
  • 2009-06. Biomechanical forces promote embryonic haematopoiesis in NATURE
  • 1996-03. Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins in NATURE
  • 2009-02. Continuous single-cell imaging of blood generation from haemogenic endothelium in NATURE
  • 2007-04-26. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1134/s0006297919030027

    DOI

    http://dx.doi.org/10.1134/s0006297919030027

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113048028


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "MRC Centre for Regenerative Medicine", 
              "id": "https://www.grid.ac/institutes/grid.483689.8", 
              "name": [
                "MRC Centre for Regenerative Medicine, University of Edinburgh, EH16 4U, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rybtsov", 
            "givenName": "S. A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal Medical-Biological Agency", 
              "id": "https://www.grid.ac/institutes/grid.465277.5", 
              "name": [
                "Federal Research and Clinical Centre of Physical-Chemical Medicine, Federal Medical-Biological Agency, 119435, Moscow, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lagarkova", 
            "givenName": "M. A.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1182/blood-2014-07-588954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001378290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001665697", 
              "https://doi.org/10.1038/leu.2010.181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1064081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001904149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2016-03-708164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001932046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2011.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002011214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.24782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002734056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80355-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003254822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-02-003327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005604469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2016.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006886697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/scd.2013.0536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006903291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2012.11.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007165720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/364064a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007278036", 
              "https://doi.org/10.1038/364064a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007477793", 
              "https://doi.org/10.1038/ni1509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007549438", 
              "https://doi.org/10.1038/nature07760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007993268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1074-7613(94)90081-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008095989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0706923105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008815446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.131193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008913124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature18633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009137223", 
              "https://doi.org/10.1038/nature18633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80581-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009153847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2016.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009328776", 
              "https://doi.org/10.1038/nrm.2016.127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009358516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009358516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2016.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009410741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.10.6477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010296345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-12-470971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010528965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011294420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-10-4209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012000031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.10.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012237517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-09-570192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012498756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-472x(02)00887-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012755202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(01)00190-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012879319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013056252", 
              "https://doi.org/10.1038/nature10783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-12-397489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013397254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80216-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014001572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0700984104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016504957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.00632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016719407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2013-12-545939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017031982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20102419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017593580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1015841108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017604141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-01-153486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018044399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0402270102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018827236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2015-03-633354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018937341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373432a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019482424", 
              "https://doi.org/10.1038/373432a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.15.7075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019671936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2005.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020289679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2005.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020482749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021741334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021882476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021882476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2006.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022181960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80165-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023382146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(13)60452-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023428181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/380171a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024074092", 
              "https://doi.org/10.1038/380171a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024113045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024113045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026113424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026113424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-08-107086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027768509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-05-1955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028099563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2014.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028133874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00697-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028687713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2013.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028810441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-06-162750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028954817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2013.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030167125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2012.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030575689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031150090", 
              "https://doi.org/10.1038/nm1342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031150090", 
              "https://doi.org/10.1038/nm1342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.110841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031496897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2010.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031545347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2010.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031665614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2014.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032053090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2014.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032053090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-03-0989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033126310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-12-193888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034329180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2016.02.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034531940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.1030620313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034634800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.11.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036528241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80283-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036952119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-06-585513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036958230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037098173", 
              "https://doi.org/10.1038/nature05725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.02596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038459682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038516726", 
              "https://doi.org/10.1038/nbt.3702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2014.01.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039160072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.02349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041945834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-08-2955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041978015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042811809", 
              "https://doi.org/10.1038/nature06685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-02-0655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043429549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v99.4.1183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043466370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044481037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2014.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044868791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1003586107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045673157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045881928", 
              "https://doi.org/10.1038/nature08073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045881928", 
              "https://doi.org/10.1038/nature08073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.12.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046125989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.1342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046404402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.040998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046818798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2004-0120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047174313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2004-0120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047174313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-08-2531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047625863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad0084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049324198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2012.06564.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049853466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049861075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/197452a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050179231", 
              "https://doi.org/10.1038/197452a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2015.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050485091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2015.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050485091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050657682", 
              "https://doi.org/10.1038/nature07619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20111688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051064874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1115828109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052267073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/bio.20133715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052772550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-06-2480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052840870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053334252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00680-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053359673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053415673", 
              "https://doi.org/10.1038/ncomms10784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gene.20190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053687846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gene.20190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053687846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2016-06-723981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1387/ijdb.103070cg", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067191181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074536919", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074610541", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074970880", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075179359", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077293421", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082272687", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082857301", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2017.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083745574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2017.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085139169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2017.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085139169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000477357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085565119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.134866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090343194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-00137-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090780635", 
              "https://doi.org/10.1038/s41467-017-00137-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.117.309195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092105982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.117.309195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092105982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.117.309195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092105982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20162012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092480029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20162012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092480029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellimm.2018.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100350074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2018.03.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103378380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2018.03.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103378380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2018.04.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103790842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0030-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103817446", 
              "https://doi.org/10.1038/s41591-018-0030-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0030-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103817446", 
              "https://doi.org/10.1038/s41591-018-0030-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2018.04.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104265914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0213-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104567059", 
              "https://doi.org/10.1038/s41586-018-0213-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0213-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104567059", 
              "https://doi.org/10.1038/s41586-018-0213-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-018-0213-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104567059", 
              "https://doi.org/10.1038/s41586-018-0213-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fcell.2018.00080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105707195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2018-04-784140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106147913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.leukres.2018.09.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107227633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2018.09.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107643445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2018.09.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107643445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2018-08-867648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107853936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2018-08-867648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107853936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2018.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107949200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2018.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107949200"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "Hematopoietic stem cells (HSCs) were the first stem cells discovered in humans. A. A. Maximov proposed an idea of blood stem cells that was confirmed later by McCulloch and Till experimentally. HSCs were the first type of stem cells to be used in clinics and ever since are being continually used. Indeed, a single HSC transplanted intravenously is capable of giving rise to all types of blood cells. In recent decades, human and animal HSC origin, development, hierarchy, and gene signature have been extensively investigated. Due to the constant need for donor blood and HSCs suitable for therapeutic transplants, the experimental possibility of obtaining HSCs in vitro by directed differentiation of pluripotent stem cells (PSCs) has been considered in recent years. However, despite all efforts, it is not yet possible to reproduce in vitro the ontogenesis of HSCs and obtain cells capable of long-term maintenance of hematopoiesis. The study of hematopoiesis in embryonic development facilitates the establishment and improvement of protocols for deriving blood cells from PCSs and allows a better understanding of the pathogenesis of various types of proliferative blood diseases, anemia, and immunodeficiency. This review focuses on the development of hematopoiesis in mammalian ontogenesis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1134/s0006297919030027", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1297322", 
            "issn": [
              "0006-2979", 
              "1608-3040"
            ], 
            "name": "Biochemistry (Moscow)", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "84"
          }
        ], 
        "name": "Development of Hematopoietic Stem Cells in the Early Mammalian Embryo", 
        "pagination": "190-204", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d35a57774eddee7e3568749a0c9c1ce0d66465b4354711e7a6aa7b9a91066952"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1134/s0006297919030027"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113048028"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1134/s0006297919030027", 
          "https://app.dimensions.ai/details/publication/pub.1113048028"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78938_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1134%2FS0006297919030027"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1134/s0006297919030027'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1134/s0006297919030027'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1134/s0006297919030027'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1134/s0006297919030027'


     

    This table displays all metadata directly associated to this object as RDF triples.

    484 TRIPLES      21 PREDICATES      161 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1134/s0006297919030027 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Nb3c6a3ddd78c476b843eee3c019180da
    4 schema:citation sg:pub.10.1038/197452a0
    5 sg:pub.10.1038/364064a0
    6 sg:pub.10.1038/373432a0
    7 sg:pub.10.1038/380171a0
    8 sg:pub.10.1038/leu.2010.181
    9 sg:pub.10.1038/nature05725
    10 sg:pub.10.1038/nature06685
    11 sg:pub.10.1038/nature07619
    12 sg:pub.10.1038/nature07760
    13 sg:pub.10.1038/nature08073
    14 sg:pub.10.1038/nature10783
    15 sg:pub.10.1038/nature18633
    16 sg:pub.10.1038/nbt.3702
    17 sg:pub.10.1038/ncomms10784
    18 sg:pub.10.1038/ni1509
    19 sg:pub.10.1038/nm1342
    20 sg:pub.10.1038/nrm.2016.127
    21 sg:pub.10.1038/s41467-017-00137-y
    22 sg:pub.10.1038/s41586-018-0213-0
    23 sg:pub.10.1038/s41591-018-0030-x
    24 https://app.dimensions.ai/details/publication/pub.1074536919
    25 https://app.dimensions.ai/details/publication/pub.1074610541
    26 https://app.dimensions.ai/details/publication/pub.1074970880
    27 https://app.dimensions.ai/details/publication/pub.1075179359
    28 https://app.dimensions.ai/details/publication/pub.1077293421
    29 https://app.dimensions.ai/details/publication/pub.1082272687
    30 https://app.dimensions.ai/details/publication/pub.1082857301
    31 https://doi.org/10.1002/bit.24782
    32 https://doi.org/10.1002/gene.20190
    33 https://doi.org/10.1002/jcp.1030620313
    34 https://doi.org/10.1002/stem.1342
    35 https://doi.org/10.1002/stem.71
    36 https://doi.org/10.1016/1074-7613(94)90081-7
    37 https://doi.org/10.1016/j.cell.2008.10.048
    38 https://doi.org/10.1016/j.cell.2013.08.007
    39 https://doi.org/10.1016/j.cellimm.2018.01.001
    40 https://doi.org/10.1016/j.celrep.2012.11.003
    41 https://doi.org/10.1016/j.devcel.2004.12.016
    42 https://doi.org/10.1016/j.devcel.2005.02.001
    43 https://doi.org/10.1016/j.devcel.2006.07.002
    44 https://doi.org/10.1016/j.devcel.2014.04.013
    45 https://doi.org/10.1016/j.exphem.2005.06.006
    46 https://doi.org/10.1016/j.exphem.2010.09.010
    47 https://doi.org/10.1016/j.exphem.2013.02.003
    48 https://doi.org/10.1016/j.exphem.2016.04.012
    49 https://doi.org/10.1016/j.exphem.2016.12.009
    50 https://doi.org/10.1016/j.exphem.2018.10.009
    51 https://doi.org/10.1016/j.immuni.2010.08.017
    52 https://doi.org/10.1016/j.immuni.2011.11.017
    53 https://doi.org/10.1016/j.immuni.2015.03.011
    54 https://doi.org/10.1016/j.immuni.2016.02.024
    55 https://doi.org/10.1016/j.immuni.2018.03.024
    56 https://doi.org/10.1016/j.immuni.2018.04.025
    57 https://doi.org/10.1016/j.immuni.2018.09.023
    58 https://doi.org/10.1016/j.leukres.2018.09.015
    59 https://doi.org/10.1016/j.molimm.2014.01.018
    60 https://doi.org/10.1016/j.stem.2007.10.001
    61 https://doi.org/10.1016/j.stem.2007.10.011
    62 https://doi.org/10.1016/j.stem.2008.06.004
    63 https://doi.org/10.1016/j.stem.2011.09.010
    64 https://doi.org/10.1016/j.stem.2012.07.002
    65 https://doi.org/10.1016/j.stem.2013.08.012
    66 https://doi.org/10.1016/j.stem.2017.01.002
    67 https://doi.org/10.1016/j.stem.2018.04.015
    68 https://doi.org/10.1016/j.stemcr.2014.02.004
    69 https://doi.org/10.1016/j.stemcr.2014.07.009
    70 https://doi.org/10.1016/j.stemcr.2017.04.003
    71 https://doi.org/10.1016/s0092-8674(00)80165-8
    72 https://doi.org/10.1016/s0092-8674(00)80283-4
    73 https://doi.org/10.1016/s0092-8674(02)00680-3
    74 https://doi.org/10.1016/s0092-8674(02)00697-9
    75 https://doi.org/10.1016/s0140-6736(13)60452-3
    76 https://doi.org/10.1016/s0301-472x(02)00887-1
    77 https://doi.org/10.1016/s1074-7613(00)80216-2
    78 https://doi.org/10.1016/s1074-7613(00)80355-6
    79 https://doi.org/10.1016/s1074-7613(00)80581-6
    80 https://doi.org/10.1016/s1074-7613(01)00190-x
    81 https://doi.org/10.1038/sj.emboj.7600878
    82 https://doi.org/10.1073/pnas.0402270102
    83 https://doi.org/10.1073/pnas.0700984104
    84 https://doi.org/10.1073/pnas.0706923105
    85 https://doi.org/10.1073/pnas.1003586107
    86 https://doi.org/10.1073/pnas.1015841108
    87 https://doi.org/10.1073/pnas.1115828109
    88 https://doi.org/10.1073/pnas.92.15.7075
    89 https://doi.org/10.1084/jem.20102419
    90 https://doi.org/10.1084/jem.20111688
    91 https://doi.org/10.1084/jem.20162012
    92 https://doi.org/10.1089/scd.2013.0536
    93 https://doi.org/10.1111/j.1749-6632.2012.06564.x
    94 https://doi.org/10.1126/science.1064081
    95 https://doi.org/10.1126/science.1219179
    96 https://doi.org/10.1126/science.aad0084
    97 https://doi.org/10.1159/000477357
    98 https://doi.org/10.1161/atvbaha.117.309195
    99 https://doi.org/10.1182/blood-2002-02-0655
    100 https://doi.org/10.1182/blood-2002-08-2531
    101 https://doi.org/10.1182/blood-2003-08-2955
    102 https://doi.org/10.1182/blood-2004-03-0989
    103 https://doi.org/10.1182/blood-2004-06-2480
    104 https://doi.org/10.1182/blood-2005-05-1955
    105 https://doi.org/10.1182/blood-2005-10-4209
    106 https://doi.org/10.1182/blood-2006-02-003327
    107 https://doi.org/10.1182/blood-2007-08-107086
    108 https://doi.org/10.1182/blood-2008-06-162750
    109 https://doi.org/10.1182/blood-2008-12-193888
    110 https://doi.org/10.1182/blood-2011-12-397489
    111 https://doi.org/10.1182/blood-2012-01-153486
    112 https://doi.org/10.1182/blood-2012-12-470971
    113 https://doi.org/10.1182/blood-2013-12-545939
    114 https://doi.org/10.1182/blood-2014-06-585513
    115 https://doi.org/10.1182/blood-2014-07-588954
    116 https://doi.org/10.1182/blood-2014-09-570192
    117 https://doi.org/10.1182/blood-2015-03-633354
    118 https://doi.org/10.1182/blood-2016-03-708164
    119 https://doi.org/10.1182/blood-2016-06-723981
    120 https://doi.org/10.1182/blood-2018-04-784140
    121 https://doi.org/10.1182/blood-2018-08-867648
    122 https://doi.org/10.1182/blood.v99.4.1183
    123 https://doi.org/10.1242/bio.20133715
    124 https://doi.org/10.1242/dev.00632
    125 https://doi.org/10.1242/dev.01130
    126 https://doi.org/10.1242/dev.01974
    127 https://doi.org/10.1242/dev.02349
    128 https://doi.org/10.1242/dev.02596
    129 https://doi.org/10.1242/dev.040998
    130 https://doi.org/10.1242/dev.110841
    131 https://doi.org/10.1242/dev.131193
    132 https://doi.org/10.1242/dev.134866
    133 https://doi.org/10.1387/ijdb.103070cg
    134 https://doi.org/10.1634/stemcells.2004-0120
    135 https://doi.org/10.1634/stemcells.2005-0256
    136 https://doi.org/10.3389/fcell.2018.00080
    137 https://doi.org/10.4049/jimmunol.174.10.6477
    138 schema:datePublished 2019-03
    139 schema:datePublishedReg 2019-03-01
    140 schema:description Hematopoietic stem cells (HSCs) were the first stem cells discovered in humans. A. A. Maximov proposed an idea of blood stem cells that was confirmed later by McCulloch and Till experimentally. HSCs were the first type of stem cells to be used in clinics and ever since are being continually used. Indeed, a single HSC transplanted intravenously is capable of giving rise to all types of blood cells. In recent decades, human and animal HSC origin, development, hierarchy, and gene signature have been extensively investigated. Due to the constant need for donor blood and HSCs suitable for therapeutic transplants, the experimental possibility of obtaining HSCs in vitro by directed differentiation of pluripotent stem cells (PSCs) has been considered in recent years. However, despite all efforts, it is not yet possible to reproduce in vitro the ontogenesis of HSCs and obtain cells capable of long-term maintenance of hematopoiesis. The study of hematopoiesis in embryonic development facilitates the establishment and improvement of protocols for deriving blood cells from PCSs and allows a better understanding of the pathogenesis of various types of proliferative blood diseases, anemia, and immunodeficiency. This review focuses on the development of hematopoiesis in mammalian ontogenesis.
    141 schema:genre research_article
    142 schema:inLanguage en
    143 schema:isAccessibleForFree false
    144 schema:isPartOf N9712db59f87f4172ba35b017b1395d4e
    145 Nafff3bbe5e31493dae3ebb0a802744fe
    146 sg:journal.1297322
    147 schema:name Development of Hematopoietic Stem Cells in the Early Mammalian Embryo
    148 schema:pagination 190-204
    149 schema:productId N2315ae8531aa4cb7a0a80b87d38e0146
    150 N3baa5bd4a25d4dc588bf85857559db9f
    151 Naab2796d51df44d0a7153649c7f6794f
    152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113048028
    153 https://doi.org/10.1134/s0006297919030027
    154 schema:sdDatePublished 2019-04-11T13:18
    155 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    156 schema:sdPublisher N7f84ff34115e49d8a8411f50c41c6399
    157 schema:url https://link.springer.com/10.1134%2FS0006297919030027
    158 sgo:license sg:explorer/license/
    159 sgo:sdDataset articles
    160 rdf:type schema:ScholarlyArticle
    161 N2315ae8531aa4cb7a0a80b87d38e0146 schema:name readcube_id
    162 schema:value d35a57774eddee7e3568749a0c9c1ce0d66465b4354711e7a6aa7b9a91066952
    163 rdf:type schema:PropertyValue
    164 N2feabf7e8dea4797b29395432fa0079e rdf:first Ncf35d555dc54411988542410fcaa4abc
    165 rdf:rest rdf:nil
    166 N3baa5bd4a25d4dc588bf85857559db9f schema:name doi
    167 schema:value 10.1134/s0006297919030027
    168 rdf:type schema:PropertyValue
    169 N4073bc6725fa4872a3d4b60cedd38055 schema:affiliation https://www.grid.ac/institutes/grid.483689.8
    170 schema:familyName Rybtsov
    171 schema:givenName S. A.
    172 rdf:type schema:Person
    173 N7f84ff34115e49d8a8411f50c41c6399 schema:name Springer Nature - SN SciGraph project
    174 rdf:type schema:Organization
    175 N9712db59f87f4172ba35b017b1395d4e schema:volumeNumber 84
    176 rdf:type schema:PublicationVolume
    177 Naab2796d51df44d0a7153649c7f6794f schema:name dimensions_id
    178 schema:value pub.1113048028
    179 rdf:type schema:PropertyValue
    180 Nafff3bbe5e31493dae3ebb0a802744fe schema:issueNumber 3
    181 rdf:type schema:PublicationIssue
    182 Nb3c6a3ddd78c476b843eee3c019180da rdf:first N4073bc6725fa4872a3d4b60cedd38055
    183 rdf:rest N2feabf7e8dea4797b29395432fa0079e
    184 Ncf35d555dc54411988542410fcaa4abc schema:affiliation https://www.grid.ac/institutes/grid.465277.5
    185 schema:familyName Lagarkova
    186 schema:givenName M. A.
    187 rdf:type schema:Person
    188 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Biological Sciences
    190 rdf:type schema:DefinedTerm
    191 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Biochemistry and Cell Biology
    193 rdf:type schema:DefinedTerm
    194 sg:journal.1297322 schema:issn 0006-2979
    195 1608-3040
    196 schema:name Biochemistry (Moscow)
    197 rdf:type schema:Periodical
    198 sg:pub.10.1038/197452a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050179231
    199 https://doi.org/10.1038/197452a0
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/364064a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007278036
    202 https://doi.org/10.1038/364064a0
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/373432a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019482424
    205 https://doi.org/10.1038/373432a0
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/380171a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024074092
    208 https://doi.org/10.1038/380171a0
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/leu.2010.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001665697
    211 https://doi.org/10.1038/leu.2010.181
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature05725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037098173
    214 https://doi.org/10.1038/nature05725
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nature06685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042811809
    217 https://doi.org/10.1038/nature06685
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nature07619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050657682
    220 https://doi.org/10.1038/nature07619
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nature07760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007549438
    223 https://doi.org/10.1038/nature07760
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nature08073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045881928
    226 https://doi.org/10.1038/nature08073
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nature10783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013056252
    229 https://doi.org/10.1038/nature10783
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nature18633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009137223
    232 https://doi.org/10.1038/nature18633
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nbt.3702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038516726
    235 https://doi.org/10.1038/nbt.3702
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/ncomms10784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053415673
    238 https://doi.org/10.1038/ncomms10784
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/ni1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007477793
    241 https://doi.org/10.1038/ni1509
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nm1342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031150090
    244 https://doi.org/10.1038/nm1342
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nrm.2016.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009328776
    247 https://doi.org/10.1038/nrm.2016.127
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/s41467-017-00137-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1090780635
    250 https://doi.org/10.1038/s41467-017-00137-y
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/s41586-018-0213-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104567059
    253 https://doi.org/10.1038/s41586-018-0213-0
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/s41591-018-0030-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1103817446
    256 https://doi.org/10.1038/s41591-018-0030-x
    257 rdf:type schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1074536919 schema:CreativeWork
    259 https://app.dimensions.ai/details/publication/pub.1074610541 schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1074970880 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1075179359 schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1077293421 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1082272687 schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1082857301 schema:CreativeWork
    265 https://doi.org/10.1002/bit.24782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002734056
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/gene.20190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053687846
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/jcp.1030620313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034634800
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/stem.1342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046404402
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/stem.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026113424
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/1074-7613(94)90081-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008095989
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.cell.2008.10.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012237517
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.cell.2013.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049861075
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.cellimm.2018.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100350074
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.celrep.2012.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007165720
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.devcel.2004.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046125989
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.devcel.2005.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020482749
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.devcel.2006.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022181960
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.devcel.2014.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032053090
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.exphem.2005.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020289679
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.exphem.2010.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031545347
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.exphem.2013.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028810441
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.exphem.2016.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006886697
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.exphem.2016.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009410741
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.exphem.2018.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107949200
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.immuni.2010.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031665614
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.immuni.2011.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036528241
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.immuni.2015.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050485091
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.immuni.2016.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034531940
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.immuni.2018.03.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103378380
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.immuni.2018.04.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104265914
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.immuni.2018.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107643445
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.leukres.2018.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107227633
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.molimm.2014.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039160072
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.stem.2007.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011294420
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.stem.2007.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044481037
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.stem.2008.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021741334
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.stem.2011.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002011214
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.stem.2012.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030575689
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.stem.2013.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030167125
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.stem.2017.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083745574
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/j.stem.2018.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103790842
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/j.stemcr.2014.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044868791
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/j.stemcr.2014.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028133874
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/j.stemcr.2017.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085139169
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/s0092-8674(00)80165-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023382146
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/s0092-8674(00)80283-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036952119
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/s0092-8674(02)00680-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053359673
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/s0092-8674(02)00697-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028687713
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/s0140-6736(13)60452-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023428181
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/s0301-472x(02)00887-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012755202
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/s1074-7613(00)80216-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014001572
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/s1074-7613(00)80355-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003254822
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s1074-7613(00)80581-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009153847
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/s1074-7613(01)00190-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012879319
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1038/sj.emboj.7600878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024113045
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1073/pnas.0402270102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018827236
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1073/pnas.0700984104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016504957
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1073/pnas.0706923105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008815446
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1073/pnas.1003586107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045673157
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1073/pnas.1015841108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017604141
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1073/pnas.1115828109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052267073
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1073/pnas.92.15.7075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019671936
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1084/jem.20102419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017593580
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1084/jem.20111688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051064874
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1084/jem.20162012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092480029
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1089/scd.2013.0536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006903291
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1111/j.1749-6632.2012.06564.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049853466
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1126/science.1064081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001904149
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1126/science.1219179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009358516
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1126/science.aad0084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049324198
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1159/000477357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085565119
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1161/atvbaha.117.309195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092105982
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1182/blood-2002-02-0655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043429549
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1182/blood-2002-08-2531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047625863
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1182/blood-2003-08-2955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041978015
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1182/blood-2004-03-0989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033126310
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1182/blood-2004-06-2480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052840870
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1182/blood-2005-05-1955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028099563
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1182/blood-2005-10-4209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012000031
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1182/blood-2006-02-003327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005604469
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1182/blood-2007-08-107086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027768509
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1182/blood-2008-06-162750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028954817
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1182/blood-2008-12-193888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034329180
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1182/blood-2011-12-397489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013397254
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1182/blood-2012-01-153486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018044399
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1182/blood-2012-12-470971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010528965
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1182/blood-2013-12-545939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017031982
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1182/blood-2014-06-585513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036958230
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1182/blood-2014-07-588954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001378290
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1182/blood-2014-09-570192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012498756
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1182/blood-2015-03-633354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018937341
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1182/blood-2016-03-708164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001932046
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1182/blood-2016-06-723981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123186
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1182/blood-2018-04-784140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106147913
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1182/blood-2018-08-867648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107853936
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1182/blood.v99.4.1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043466370
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1242/bio.20133715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052772550
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1242/dev.00632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016719407
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1242/dev.01130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007993268
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1242/dev.01974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053334252
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1242/dev.02349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041945834
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1242/dev.02596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038459682
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1242/dev.040998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046818798
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1242/dev.110841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031496897
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1242/dev.131193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008913124
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1242/dev.134866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090343194
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1387/ijdb.103070cg schema:sameAs https://app.dimensions.ai/details/publication/pub.1067191181
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1634/stemcells.2004-0120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047174313
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1634/stemcells.2005-0256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021882476
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.3389/fcell.2018.00080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105707195
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.4049/jimmunol.174.10.6477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010296345
    478 rdf:type schema:CreativeWork
    479 https://www.grid.ac/institutes/grid.465277.5 schema:alternateName Federal Medical-Biological Agency
    480 schema:name Federal Research and Clinical Centre of Physical-Chemical Medicine, Federal Medical-Biological Agency, 119435, Moscow, Russia
    481 rdf:type schema:Organization
    482 https://www.grid.ac/institutes/grid.483689.8 schema:alternateName MRC Centre for Regenerative Medicine
    483 schema:name MRC Centre for Regenerative Medicine, University of Edinburgh, EH16 4U, Edinburgh, UK
    484 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...