Mitochondria-targeted plastoquinone antioxidant SkQR1 has positive effect on memory of rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05-10

AUTHORS

E. V. Stelmashook, A. V. Stavrovskaya, N. G. Yamshchikova, A. S. Ol’shanskii, N. A. Kapay, O. V. Popova, L. G. Khaspekov, V. G. Skrebitsky, N. K. Isaev

ABSTRACT

A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 μmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice significantly increases the synaptic transmission efficiency of the pyramidal neurons of the CA1 field. The findings indicate that SkQR1 has a positive effect on memory processes. More... »

PAGES

592-595

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006297915050119

DOI

http://dx.doi.org/10.1134/s0006297915050119

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002652636

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26071778


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