Identification of proteins specifically interacting with YB-1 mRNA 3′ UTR and the effect of hnRNP Q on YB-1 mRNA translation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

D. N. Lyabin, L. F. Nigmatullina, A. N. Doronin, I. A. Eliseeva, L. P. Ovchinnikov

ABSTRACT

In this study, proteins specifically interacting with the 3' untranslated region (UTR) of mRNA of the multifunctional Y-box-binding protein 1 (YB-1) were identified. One of these, hnRNP Q, was shown to specifically interact with the regulatory element (RE) in YB-1 mRNA 3' UTR and to inhibit translation of this mRNA. Its binding to the RE was accompanied by displacement from this element of the poly(A)-binding protein (PABP), a positive regulator of YB-1 mRNA translation, and by enhanced binding of the negative YB-1 mRNA translation regulator - YB-1 itself. More... »

PAGES

651-659

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006297913060102

DOI

http://dx.doi.org/10.1134/s0006297913060102

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039202416

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23980891


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