Ontology type: schema:ScholarlyArticle
2011-12
AUTHORSI. A. Eliseeva, E. R. Kim, S. G. Guryanov, L. P. Ovchinnikov, D. N. Lyabin
ABSTRACTThis review describes the structure and functions of Y-box binding protein 1 (YB-1) and its homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the participation of YB-1 in DNA reparation and transcription, mRNA splicing and translation are systematized. Results on interactions of YB-1 with cytoskeleton components and its possible role in mRNA localization are discussed. Data on intracellular distribution of YB-1, its redistribution between the nucleus and the cytoplasm, and its secretion and extracellular functions are summarized. The effect of YB-1 on cell differentiation, its involvement in extra- and intracellular signaling pathways, and its role in early embryogenesis are described. The mechanisms of regulation of YB-1 expression in the cell are presented. Special attention is paid to the involvement of YB-1 in oncogenic cell transformation, multiple drug resistance, and dissemination of tumors. Both the oncogenic and antioncogenic activities of YB-1 are reviewed. The potential use of YB-1 in diagnostics and therapy as an early cancer marker and a molecular target is discussed. More... »
PAGES1402-1433
http://scigraph.springernature.com/pub.10.1134/s0006297911130049
DOIhttp://dx.doi.org/10.1134/s0006297911130049
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1052588168
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22339596
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1134/s0006297911130049'
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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1134/s0006297911130049'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1134/s0006297911130049'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1134/s0006297911130049'
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