Foot and mouth disease virus polyepitope protein produced in bacteria and plants induces protective immunity in guinea pigs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-03

AUTHORS

E. P. Andrianova, S. R. Krementsugskaia, N. N. Lugovskaia, T. K. Mayorova, V. V. Borisov, M. A. Eldarov, N. V. Ravin, A. S. Folimonov, K. G. Skryabin

ABSTRACT

The goal of this project was to develop an alternative foot and mouth disease (FMD) vaccine candidate based on a recombinant protein consisting of efficient viral epitopes. A recombinant gene was designed that encodes B-cell epitopes of proteins VP1 and VP4 and T-cell epitopes of proteins 2C and 3D. The polyepitope protein (H-PE) was produced in E. coli bacteria or in N. benthamiana plants using a phytovirus expression system. The methods of extraction and purification of H-PE proteins from bacteria and plants were developed. Immunization of guinea pigs with the purified H-PE proteins induced an efficient immune response against foot and mouth disease virus (FMDV) serotype O/Taiwan/99 and protection against the disease. The polyepitope protein H-PE can be used as a basis for developing a new recombinant vaccine against FMD. More... »

PAGES

339-346

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006297911030072

DOI

http://dx.doi.org/10.1134/s0006297911030072

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019694548

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21568869


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