Chemical characterization and anti-inflammatory effect of rauvolfian, a pectic polysaccharide of Rauvolfia callus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07

AUTHORS

S. V. Popov, V. G. Vinter, O. A. Patova, P. A. Markov, I. R. Nikitina, R. G. Ovodova, G. Yu. Popova, A. S. Shashkov, Yu. S. Ovodov

ABSTRACT

The pectic polysaccharide named rauvolfian RS was obtained from the dried callus of Rauvolfia serpentina L. by extraction with 0.7% aqueous ammonium oxalate. Crude rauvolfian RS was purified using membrane ultrafiltration to yield the purified rauvolfian RSP in addition to glucan as admixture from the callus, with molecular weights 300 and 100-300 kD, respectively. A peroral pretreatment of mice with the crude and purified samples of rauvolfian (RS and RSP) was found to decrease colonic macroscopic scores, the total area of damage, and tissue myeloperoxidase activity in colons as compared with a colitis group. RS and RSP were shown to stimulate production of mucus by colons of the colitis mice. RSP appeared to be an active constituent of the parent RS. The glucan failed to possess anti-inflammatory activity. More... »

PAGES

778-784

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006297907070139

DOI

http://dx.doi.org/10.1134/s0006297907070139

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001175266

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17680771


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