Mouse retinal progenitor cell (RPC) cocultivation with retinal pigment epithelial cell culture affects features of RPC differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07

AUTHORS

I. V. Kholodenko, A. A. Buzdin, R. V. Kholodenko, J. A. Baibikova, V. F. Sorokin, V. N. Yarygin, E. D. Sverdlov

ABSTRACT

We provide evidence that coculturing of retinal progenitor cells (RPC) with retinal pigment epithelial cells significantly biases the standard in vitro RPC differentiation patterns. In particular, in cocultivation experiments RPCs lost the ability to differentiate spontaneously and displayed approximately 2.1-2.4-fold increase in immunoreactivity to the neural stem cell marker nestin and approximately 1.6-1.7-fold increase in rod photoreceptor cell rhodopsin marker immunoreactivity. The data suggest the influence of the intercellular interaction networks on RPC differentiation. More... »

PAGES

767-774

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006297906070091

DOI

http://dx.doi.org/10.1134/s0006297906070091

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025958441

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16903831


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