YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-03

AUTHORS

I. S. Severina, N. V. Pyatakova, A. Yu. Shchegolev, G. V. Ponomarev

ABSTRACT

The influence of protoporphyrin IX derivatives—2,4-di(1-methoxyethyl)-deuteroporphyrin IX disodium salt (dimegin) and hematoporphyrin IX (HP)—on the activation of human platelet soluble guanylate cyclase by sodium nitroprusside was investigated. Dimegin and HP, like 1-benzyl-3-(hydroxymethyl-2-furyl)indazole (YC-1), produce synergistic effects on the activation of soluble guanylate cyclase by sodium nitroprusside. The synergistic activation of the enzyme by the combination of 10 µM sodium nitroprusside and 5 µM dimegin (or 5 µM HP) was 190 ± 19 and 134 ± 10%, respectively. The synergistic activation of guanylate cyclase by 3 µM YC-1 and 10 µM sodium nitroprusside was 255 ± 19%. Dimegin and HP had no effect on the activation of guanylate cyclase by YC-1; they did not change the synergistic effect of YC-1 (3 µM) and sodium nitroprusside (10 µM) on guanylate cyclase activity. The synergistic activation of NO-stimulated guanylate cyclase activity by dimegin and HP represents a new biochemical effect of these compounds that may have important pharmacotherapeutic and physiological significance. More... »

PAGES

340-344

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0006297906030163

DOI

http://dx.doi.org/10.1134/s0006297906030163

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029791045

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16545073


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