Optimization of the Method of Obtaining 9α-Hydroxy-androst-4-ene-3,17-dione—the Key Intermediate in the Synthesis of Highly Active Fluorinated Corticosteroids from Phytosterols View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

N. V. Karpova, T. S. Stytsenko, V. V. Yaderets, V. A. Andryushina, V. V. Dzhavakhiya

ABSTRACT

A method of phytosterol conversion into 9α-hydroxy-androstenedione under high loads of steroid substrate has been developed with the use of mixed cultures of the actinobacteria M. neoaurum and R. erythropolis. The introduction of a 9α-hydroxylating culture after the first 70 h of conversion made it possible to increase process selectivity and to exclude the use of methylcyclodextrin, which is expensive and difficult to regenerate. More... »

PAGES

37-40

References to SciGraph publications

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  • 2006-11-30. Steroid-1-dehydrogenase of Mycobacterium sp. VKM Ac-1817D strain producing 9α-hydroxy-androst-4-ene-3,17-dione from sitosterol in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2010-03-05. A New Steroid-Transforming Strain of Mycobacterium neoaurum and Cloning of 3-Ketosteroid 9α-Hydroxylase in NwIB-01 in APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
  • 2015-05. Transformation of wood industry waste into key intermediates for pharmaceutical substances: Biotechnological study in RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B
  • 1985-02. Sequential conversion of cortexolone to prednisolone by immobilized mycelia of Curvularia lunata and immobilized cells of Arthrobacter simplex in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2009-02-03. Rapid Screening and Isolation of a Fungus for Sitosterol to Androstenedione Biotransformation in APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
  • 2008-01. Conversion of phytosterols into androstenedione by Mycobacterium neoaurum in APPLIED BIOCHEMISTRY AND MICROBIOLOGY
  • 2007-05. Preparation of androsta-1,4-diene-3,17-dione from sterols using Mycobacterium neoaurum VKPM Ac-1656 strain in RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
  • 2011-07-05. Transformation of Δ4-3-ketosteroids by free and immobilized cells of Rhodococcus erythropolis actinobacterium in APPLIED BIOCHEMISTRY AND MICROBIOLOGY
  • 1981-01. Modeling and optimization of steroid transformation in a mixed culture in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2009-07-10. The introduction of the 9α-hydroxy group into androst-4-en-3,17-dione using a new actinobacterium strain in APPLIED BIOCHEMISTRY AND MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1134/s0003683819010071

    DOI

    http://dx.doi.org/10.1134/s0003683819010071

    DIMENSIONS

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