Neutralization of anticoagulant activity of heparin by N-[(2-hydroxy-3-trimethylammonium) propyl] chloride derivatives of chitosan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07-27

AUTHORS

B. Ts. Shagdarova, N. N. Drozd, A. V. Il’ina, Yu. S. Logvinova, V. P. Varlamov

ABSTRACT

Alkylated derivatives of low molecular weight chitosan with different substitution degrees of 98, 40, and 9% (I, II, and III respectively) have been synthesized. The structure of the obtained derivatives was defined by spectral assays (IR-spectroscopy and proton magnetic resonance). Chitosan derivatives were characterized with positive zeta-potential (33–51 mV) and solubility from 2 to 100 mg/mL in pH 7.4 and 25°C. It was shown that, at a concentration of 0.0014–0.0029 mg/mL, derivative I, as well as protamine sulfate, could be used to neutralize the anticoagulant activity of unfractionated or low molecular weight heparin. At a concentration of 0.0029–0.58 mg/mL, derivative I enhanced platelet aggregation, which would be necessary when hemostatic compounds or materials were used. Derivatives II and III enhanced platelet aggregation to a lesser extent. More... »

PAGES

445-451

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0003683816040141

DOI

http://dx.doi.org/10.1134/s0003683816040141

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040618147


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