Enzymatic synthesis of β-lactam acids (review) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-11

AUTHORS

A. V. Sklyarenko, M. A. El’darov, V. B. Kurochkina, S. V. Yarotsky

ABSTRACT

The currently known methods of enzymatic β-lactam synthesis, as well as the enzymes and heterogeneous biocatalysts used for this purpose, are presented, and the published reports on advances in the field of enzymatic synthesis of selected antibiotics belonging to the groups of penicillin acids and cephalosporin acids are summarized in the present review. The key conditions and parameters of biocatalytic processes, such as the biocatalyst form, concentration of the precursor compounds, solvent type, pH, temperature, etc. are analyzed and compared, and guidelines for further optimization of β-lactam synthesis are given. The present review may be of use for a wide range of readers, as well as to enzymology and biotechnology experts. More... »

PAGES

627-640

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0003683815060150

DOI

http://dx.doi.org/10.1134/s0003683815060150

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026755376


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