Conversion of 17α-methyltestosterone to methandrostenolone by the bacterium pimelobacter simplex VKPM Ac-1632 with the presence of cyclodextrins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-10-28

AUTHORS

A. V. Druzhinina, V. A. Andryushina, T. S. Stytsenko, N. E. Voishvillo

ABSTRACT

Conditions of conversion of 17α-methyltestosterone to methandrostenolone with the presence of modified β-cyclodextrins (methylcyclodextrin, hydroxypropylcyclodextrin, and hydroxyethylcyclodextrin) in the steroid: cyclodextrin ratio 1: 1 were studied. The experimental solutions of modified β-cyclodextrins were prepared in deionized water with 5–7% methanol. Under the conditions found to be optimal, 1,2–dehydrogenation of 17α-methyltestosterone was carried out with 2–4 g/l Pimelobacter simplex VKPM Ac-1632 biomass. At the substrate concentration 5–20 g/l, the reaction occurred for 1–15 h without any by-products. The maximum rate of methandrostenolone accumulation was observed with hydroxypropylcyclodextrin. The methylcyclodextrin solution can be reused for complete 17α-methyltestosterone conversion at the concentration 5 g/l. More... »

PAGES

580-584

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1134/s0003683808060045

DOI

http://dx.doi.org/10.1134/s0003683808060045

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049348241


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