Selective gene therapy for prostate cancer cells using liposomes conjugated with IgM type monoclonal antibody against prostate-specific membrane antigen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-03

AUTHORS

Shusei Ikegami, Takushi Tadakuma, Kazuo Yamakami, Takeshi Ono, Satoshi Suzuki, Ichiro Yoshimura, Tomohiko Asano, Masamichi Hayakawa

ABSTRACT

Prostate cancer cells express prostate-specific membrane antigen (PSMA). We developed an IgM type monoclonal antibody against PSMA. The antibody was coupled to poly-L-lysine and thereafter this conjugate was mixed with cationic liposomes containing plasmid DNA. The antibody-liposome complex was tested whether it could deliver the gene of interest selectively to the PSMA positive cells. As assessed by β-galactosidase reporter gene, the transfection efficiency was 13.2% with anti-PSMA-liposome complex as compared to 4% with control IgM liposome complex. In contrast., no such differences were observed in PSMA negative PC-3, DU145 and T24 cells. Furthermore, in the suicide gene therapy in vitro with thymidine base gene plus ganciclovir system, anti-PSMA liposome complex demonstrated a selective growth inhibitory effect on PSMA positive LNCaP cells but not on PSMA negative cell lines. More... »

PAGES

17-23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1749-0774.2005.tb00053.x

DOI

http://dx.doi.org/10.1111/j.1749-0774.2005.tb00053.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011172608

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16130896


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