Liposome‐mediated Gene Therapy in the Kidney View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-03

AUTHORS

ITO Keiichi, CHEN Jie, Tomohiko ASANO, E. Darracott VAUGHAN, Dix P. POPPAS, Masamichi HAYAKAWA, Diane FELSEN

ABSTRACT

Gene therapy directed to the kidney has been attempted to improve renal disorders such as inherited kidney diseases and common renal diseases that cause interstitial fibrosis, tubular atrophy, and glomerulosclerosis. Viral and non-viral vectors have been tried and been modulated to obtain sufficient transgene expression. However, gene delivery to the kidney is usually difficult because of characteristics of renal cell biology. Among non-viral vectors, the liposome system is a promising procedure for kidney-targeted gene therapy. Using cationic liposome, tubular cells were effectively transduced by retrograde injection of liposome/cDNA complex. Although transgene expression was reportedly modest using cationic liposomes, this method improved renal disease models such as carbonic anhydrase II deficiency and unilateral ureteral obstruction. In contrast, HVJ-liposome system is an effective transfection method to glomerular cells using intra-renal arterial infusion and improved glomerular disease models such as glomerulonephritis and glomerulosclerosis. In addition, intra-renal pelvic injection of DNA by HVJ-liposome system showed transgene expression in interstitial fibroblasts. In kidney-targeted gene therapy, liposome-mediated gene transfer is an attractive method because of its simplicity and reduced toxicity. In spite of modest transgene expression, several renal disease models were successfully modulated by liposome system. Although one limitation of liposome-mediated gene delivery is the duration of transgene expression, the liposome/cDNA complex can be repeatedly administered due to the absence of an immune response. More... »

PAGES

17-28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1749-0774.2004.tb00016.x

DOI

http://dx.doi.org/10.1111/j.1749-0774.2004.tb00016.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039304336

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15369133


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