Association Between Genetic Variants in the IL-23R Gene and Early-Onset Crohn's Disease: Results From a Case-Control and Family-Based Study Among ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-03

AUTHORS

Devendra K Amre, David Mack, David Israel, Kenneth Morgan, Philippe Lambrette, Liliane Law, Guy Grimard, Colette Deslandres, Alfreda Krupoves, Vytautas Bucionis, Irina Costea, Vishnee Bissonauth, Houda Feguery, Savio D'Souza, Emile Levy, Ernest G Seidman

ABSTRACT

BACKGROUND AND OBJECTIVES: Interleukin (IL)-23 is a key regulator of inflammation and influences the activities of T-helper 17 (Th-17) lymphocytes. Recent reports indicate that variants in the gene coding for its receptor (IL-23R) are strongly associated with Crohn's disease (CD). We investigated whether DNA variants in the IL-23R gene determine susceptibility for CD in Canadian children. DESIGN AND METHODS: A case-control and case-parent trio design was implemented at three pediatric centers across Canada. Cases of CD ( More... »

PAGES

ajg200850126

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2007.01661.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2007.01661.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034808513

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18047539


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