The Effect of Age on Response to Therapy With Peginterferon α Plus Ribavirin in a Cohort of Patients With Chronic ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07

AUTHORS

Giorgio Antonucci, Maria Antonella Longo, Claudio Angeletti, Francesco Vairo, Alessandra Oliva, Ubaldo Visco Comandini, Guido Tocci, Evangelo Boumis, Pasquale Noto, Maria Carmela Solmone, Maria R Capobianchi, Enrico Girardi

ABSTRACT

OBJECTIVES: In many industrialized countries HCV infection is characterized by an increasing prevalence during ageing; however, data on the efficacy of treatment among older patients are scarce. This study was set up to evaluate the effect of age on the treatment of chronic HCV hepatitis with peginterferon alpha plus ribavirin. METHODS: We retrospectively reviewed medical records of 153 adult patients with chronic HCV hepatitis treated with combination therapy; 30 of them (19.6%) were 65 years of age or older. RESULTS: In multivariable analysis, age groups >/=40 years had similar odds of achieving sustained virologic response (P= 0.71) and significantly lower odds of sustained response compared with younger patients (odds ratio [OR] 0.16, 95% confidence interval [CI] 0.05-0.59, P= 0.006; OR 0.13, 95% CI 0.03-0.49, P= 0.002; OR 0.21, 95% CI 0.05-0.91, P= 0.037 for patients aged 40-49 years, 50-64 years, and older than 64 years, respectively). The effect of age was present in the 74 patients infected with genotype 1 or 4 (P= 0.04), while among the 79 patients with genotype 2 or 3 sustained virologic response rates were relatively uniform, with no statistically significant differences. CONCLUSIONS: The probability of good response to combination treatment with peginterferon alpha plus ribavirin is decreased for patients aged more than 40 years infected with genotype 1 or 4, but patients aged more than 65 had a similar rate of response to those aged 40-64 years. Combination treatment may be safely extended to elderly patients with no major contraindications. More... »

PAGES

ajg2007277

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2007.01201.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2007.01201.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045756257

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17403072


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