Expression of PD-1, PD-L1, and PD-L2 in the Liver in Autoimmune Liver Diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02-01

AUTHORS

Norikazu Mataki, Kentaro Kikuchi, Toshihiro Kawai, Masaaki Higashiyama, Yoshikiyo Okada, Chie Kurihara, Ryota Hokari, Atsushi Kawaguchi, Shigeaki Nagao, Toshiro Kondo, Kazuro Itoh, Hiroshi Miyakawa, Soichiro Miura

ABSTRACT

OBJECTIVES: PD-L1 (also B7-H1) and PD-L2 (also B7-DC) are ligands for programmed death-1 (PD-1), which is a member of the CD28/B7 superfamily of costimulatory molecules and plays an inhibitory role on the periphery. Impaired regulation of this system may cause disruption to self-tolerance leading to autoimmunity; however, the role of these molecules in the liver is unknown. Therefore, we examined the expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases. METHODS: We examined the liver expression of these molecules in autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) with no previous medical treatment using immunohistochemical staining and real-time PCR, and compared with chronic hepatitis type C (CHC) as a control. RESULTS: Although PD-1, PD-L1, and PD-L2 were expressed in the liver in AIH, PBC, as well as CHC, the expressions were relatively lower in PBC. In AIH, despite more severe inflammation than in CHC, the expression of these molecules was not greater than in CHC, and when compared with the relative expression of PD-L1, PD-L2 was lower in AIH. PD-L1 and PD-L2 expressions were well correlated with the level of IFN-gamma; however, relatively decreased induction for PD-L1 and PD-L2 by IFN-gamma was observed in AIH or PBC than in CHC. CONCLUSION: Modulation of PD-1/PD-L1 and PD-L2 systems may play a role in the development of autoimmune liver diseases. More... »

PAGES

ajg200751

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00948.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2006.00948.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037785698

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17311651


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35 schema:description OBJECTIVES: PD-L1 (also B7-H1) and PD-L2 (also B7-DC) are ligands for programmed death-1 (PD-1), which is a member of the CD28/B7 superfamily of costimulatory molecules and plays an inhibitory role on the periphery. Impaired regulation of this system may cause disruption to self-tolerance leading to autoimmunity; however, the role of these molecules in the liver is unknown. Therefore, we examined the expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases. METHODS: We examined the liver expression of these molecules in autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) with no previous medical treatment using immunohistochemical staining and real-time PCR, and compared with chronic hepatitis type C (CHC) as a control. RESULTS: Although PD-1, PD-L1, and PD-L2 were expressed in the liver in AIH, PBC, as well as CHC, the expressions were relatively lower in PBC. In AIH, despite more severe inflammation than in CHC, the expression of these molecules was not greater than in CHC, and when compared with the relative expression of PD-L1, PD-L2 was lower in AIH. PD-L1 and PD-L2 expressions were well correlated with the level of IFN-gamma; however, relatively decreased induction for PD-L1 and PD-L2 by IFN-gamma was observed in AIH or PBC than in CHC. CONCLUSION: Modulation of PD-1/PD-L1 and PD-L2 systems may play a role in the development of autoimmune liver diseases.
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43 CD28/B7
44 IFN-gamma
45 PCR
46 PD-1
47 PD-1/PD-L1
48 PD-L1
49 PD-L2
50 PD-L2 expression
51 PD-L2 systems
52 autoimmune hepatitis
53 autoimmune liver disease
54 autoimmunity
55 biliary cirrhosis
56 chronic hepatitis type C
57 cirrhosis
58 control
59 costimulatory molecules
60 death-1
61 development
62 disease
63 disruption
64 expression
65 expression of PD-1
66 hepatitis
67 hepatitis type C
68 immunohistochemical staining
69 impaired regulation
70 induction
71 inflammation
72 inhibitory role
73 levels
74 ligands
75 liver
76 liver disease
77 liver expression
78 medical treatment
79 members
80 modulation
81 molecules
82 periphery
83 previous medical treatment
84 primary biliary cirrhosis
85 real-time PCR
86 regulation
87 relative expression
88 role
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90 staining
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