Elevated Plasma Osteopontin Levels in Patients with Hepatocellular Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07-18

AUTHORS

Jin Kim, Seung S Ki, Sang D Lee, Chul J Han, Yu C Kim, Sun H Park, Soo Y Cho, Young-Joon Hong, Hyo Y Park, Myoungjin Lee, Ha H Jung, Kee H Lee, Sook-Hyang Jeong

ABSTRACT

OBJECTIVES: Osteopontin (OPN) is a secreted glycoprotein, frequently associated with various tumors. We investigated the usefulness of plasma OPN level as a biomarker for hepatocellular carcinoma (HCC). METHODS: We determined plasma levels of OPN, alpha-fetoprotein (AFP), and prothrombin induced by vitamin K absence II (PIVKA II) in a group of 62 HCC patients, in 60 patients with chronic liver diseases, and in 60 healthy control individuals using a standardized ELISA kit. To determine the source of elevated plasma level of OPN, immunohistochemical analysis of 285 HCC samples on tissue microarray was performed. RESULTS: Plasma OPN levels in the HCC patients (median 954 ng/mL, range 168-5,742) were significantly higher (p-value < 0.001) than those patients with chronic liver diseases (381 ng/mL, 29-1,688) or of a healthy control group (155 ng/mL, 10-766). Within the HCC patient group, plasma OPN level increased significantly with advancing degree of Child-Pugh class and of tumor stage. Diagnostic sensitivity and specificity of OPN for HCC was 87% and 82%, respectively (cut-off value: 617.6 ng/mL). OPN had a greater area under curve value (0.898) than AFP (0.745) or PIVKA II (0.578), suggesting superior diagnostic accuracy of OPN. Immunohistochemistry of 285 samples of HCC showed that OPN was expressed in 92 of 285 tumors (32.3%). OPN expression was found in the malignant hepatocytes and cancer-infiltrating macrophages, not in the noncancerous hepatocytes or Kupffer cells. CONCLUSIONS: These data propose elevated plasma OPN levels as a potential biomarker for HCC. More... »

PAGES

ajg2006379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00679.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2006.00679.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051689732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16848813


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32 schema:description OBJECTIVES: Osteopontin (OPN) is a secreted glycoprotein, frequently associated with various tumors. We investigated the usefulness of plasma OPN level as a biomarker for hepatocellular carcinoma (HCC). METHODS: We determined plasma levels of OPN, alpha-fetoprotein (AFP), and prothrombin induced by vitamin K absence II (PIVKA II) in a group of 62 HCC patients, in 60 patients with chronic liver diseases, and in 60 healthy control individuals using a standardized ELISA kit. To determine the source of elevated plasma level of OPN, immunohistochemical analysis of 285 HCC samples on tissue microarray was performed. RESULTS: Plasma OPN levels in the HCC patients (median 954 ng/mL, range 168-5,742) were significantly higher (p-value < 0.001) than those patients with chronic liver diseases (381 ng/mL, 29-1,688) or of a healthy control group (155 ng/mL, 10-766). Within the HCC patient group, plasma OPN level increased significantly with advancing degree of Child-Pugh class and of tumor stage. Diagnostic sensitivity and specificity of OPN for HCC was 87% and 82%, respectively (cut-off value: 617.6 ng/mL). OPN had a greater area under curve value (0.898) than AFP (0.745) or PIVKA II (0.578), suggesting superior diagnostic accuracy of OPN. Immunohistochemistry of 285 samples of HCC showed that OPN was expressed in 92 of 285 tumors (32.3%). OPN expression was found in the malignant hepatocytes and cancer-infiltrating macrophages, not in the noncancerous hepatocytes or Kupffer cells. CONCLUSIONS: These data propose elevated plasma OPN levels as a potential biomarker for HCC.
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40 ELISA kit
41 Elevated Plasma Osteopontin Levels
42 HCC patient group
43 HCC patients
44 HCC samples
45 Kupffer cells
46 OPN expression
47 OPN levels
48 PIVKA-II
49 accuracy
50 alpha-fetoprotein
51 analysis
52 area
53 biomarkers
54 carcinoma
55 cells
56 chronic liver disease
57 class
58 control group
59 control individuals
60 curve values
61 degree
62 diagnostic accuracy
63 diagnostic sensitivity
64 disease
65 elevated plasma OPN levels
66 elevated plasma levels
67 expression
68 glycoprotein
69 greater area
70 group
71 healthy control group
72 healthy control individuals
73 hepatocellular carcinoma
74 hepatocytes
75 immunohistochemical analysis
76 immunohistochemistry
77 individuals
78 kit
79 levels
80 liver disease
81 macrophages
82 malignant hepatocytes
83 microarrays
84 noncancerous hepatocytes
85 osteopontin
86 osteopontin levels
87 patient group
88 patients
89 plasma OPN levels
90 plasma levels
91 plasma osteopontin levels
92 potential biomarkers
93 prothrombin
94 samples
95 samples of HCC
96 sensitivity
97 source
98 specificity
99 specificity of osteopontin
100 stage
101 standardized ELISA kit
102 superior diagnostic accuracy
103 tissue microarray
104 tumor stage
105 tumors
106 usefulness
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