Elevated Plasma Osteopontin Levels in Patients with Hepatocellular Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07-18

AUTHORS

Jin Kim, Seung S Ki, Sang D Lee, Chul J Han, Yu C Kim, Sun H Park, Soo Y Cho, Young-Joon Hong, Hyo Y Park, Myoungjin Lee, Ha H Jung, Kee H Lee, Sook-Hyang Jeong

ABSTRACT

OBJECTIVES: Osteopontin (OPN) is a secreted glycoprotein, frequently associated with various tumors. We investigated the usefulness of plasma OPN level as a biomarker for hepatocellular carcinoma (HCC). METHODS: We determined plasma levels of OPN, alpha-fetoprotein (AFP), and prothrombin induced by vitamin K absence II (PIVKA II) in a group of 62 HCC patients, in 60 patients with chronic liver diseases, and in 60 healthy control individuals using a standardized ELISA kit. To determine the source of elevated plasma level of OPN, immunohistochemical analysis of 285 HCC samples on tissue microarray was performed. RESULTS: Plasma OPN levels in the HCC patients (median 954 ng/mL, range 168-5,742) were significantly higher (p-value < 0.001) than those patients with chronic liver diseases (381 ng/mL, 29-1,688) or of a healthy control group (155 ng/mL, 10-766). Within the HCC patient group, plasma OPN level increased significantly with advancing degree of Child-Pugh class and of tumor stage. Diagnostic sensitivity and specificity of OPN for HCC was 87% and 82%, respectively (cut-off value: 617.6 ng/mL). OPN had a greater area under curve value (0.898) than AFP (0.745) or PIVKA II (0.578), suggesting superior diagnostic accuracy of OPN. Immunohistochemistry of 285 samples of HCC showed that OPN was expressed in 92 of 285 tumors (32.3%). OPN expression was found in the malignant hepatocytes and cancer-infiltrating macrophages, not in the noncancerous hepatocytes or Kupffer cells. CONCLUSIONS: These data propose elevated plasma OPN levels as a potential biomarker for HCC. More... »

PAGES

ajg2006379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00679.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2006.00679.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051689732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16848813


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32 schema:description OBJECTIVES: Osteopontin (OPN) is a secreted glycoprotein, frequently associated with various tumors. We investigated the usefulness of plasma OPN level as a biomarker for hepatocellular carcinoma (HCC). METHODS: We determined plasma levels of OPN, alpha-fetoprotein (AFP), and prothrombin induced by vitamin K absence II (PIVKA II) in a group of 62 HCC patients, in 60 patients with chronic liver diseases, and in 60 healthy control individuals using a standardized ELISA kit. To determine the source of elevated plasma level of OPN, immunohistochemical analysis of 285 HCC samples on tissue microarray was performed. RESULTS: Plasma OPN levels in the HCC patients (median 954 ng/mL, range 168-5,742) were significantly higher (p-value < 0.001) than those patients with chronic liver diseases (381 ng/mL, 29-1,688) or of a healthy control group (155 ng/mL, 10-766). Within the HCC patient group, plasma OPN level increased significantly with advancing degree of Child-Pugh class and of tumor stage. Diagnostic sensitivity and specificity of OPN for HCC was 87% and 82%, respectively (cut-off value: 617.6 ng/mL). OPN had a greater area under curve value (0.898) than AFP (0.745) or PIVKA II (0.578), suggesting superior diagnostic accuracy of OPN. Immunohistochemistry of 285 samples of HCC showed that OPN was expressed in 92 of 285 tumors (32.3%). OPN expression was found in the malignant hepatocytes and cancer-infiltrating macrophages, not in the noncancerous hepatocytes or Kupffer cells. CONCLUSIONS: These data propose elevated plasma OPN levels as a potential biomarker for HCC.
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39 schema:keywords Child-Pugh class
40 ELISA kit
41 Elevated Plasma Osteopontin Levels
42 HCC patient group
43 HCC patients
44 HCC samples
45 K absence II
46 Kupffer cells
47 OPN expression
48 OPN levels
49 PIVKA II
50 absence II
51 accuracy
52 alpha-fetoprotein
53 analysis
54 area
55 biomarkers
56 cancer-infiltrating macrophages
57 carcinoma
58 cells
59 chronic liver disease
60 class
61 control group
62 control individuals
63 curve values
64 data propose elevated plasma OPN levels
65 degree
66 diagnostic accuracy
67 diagnostic sensitivity
68 disease
69 elevated plasma OPN levels
70 elevated plasma levels
71 expression
72 glycoprotein
73 greater area
74 group
75 healthy control group
76 healthy control individuals
77 hepatocellular carcinoma
78 hepatocytes
79 immunohistochemical analysis
80 immunohistochemistry
81 individuals
82 kit
83 levels
84 liver disease
85 macrophages
86 malignant hepatocytes
87 microarrays
88 noncancerous hepatocytes
89 osteopontin
90 osteopontin levels
91 patient group
92 patients
93 plasma OPN levels
94 plasma levels
95 plasma osteopontin levels
96 potential biomarkers
97 propose elevated plasma OPN levels
98 prothrombin
99 samples
100 samples of HCC
101 sensitivity
102 source
103 specificity
104 specificity of osteopontin
105 stage
106 standardized ELISA kit
107 superior diagnostic accuracy
108 tissue microarray
109 tumor stage
110 tumors
111 usefulness
112 values
113 vitamin K absence II
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