Ontology type: schema:ScholarlyArticle
2006-07-18
AUTHORSJin Kim, Seung S Ki, Sang D Lee, Chul J Han, Yu C Kim, Sun H Park, Soo Y Cho, Young-Joon Hong, Hyo Y Park, Myoungjin Lee, Ha H Jung, Kee H Lee, Sook-Hyang Jeong
ABSTRACTOBJECTIVES: Osteopontin (OPN) is a secreted glycoprotein, frequently associated with various tumors. We investigated the usefulness of plasma OPN level as a biomarker for hepatocellular carcinoma (HCC). METHODS: We determined plasma levels of OPN, alpha-fetoprotein (AFP), and prothrombin induced by vitamin K absence II (PIVKA II) in a group of 62 HCC patients, in 60 patients with chronic liver diseases, and in 60 healthy control individuals using a standardized ELISA kit. To determine the source of elevated plasma level of OPN, immunohistochemical analysis of 285 HCC samples on tissue microarray was performed. RESULTS: Plasma OPN levels in the HCC patients (median 954 ng/mL, range 168-5,742) were significantly higher (p-value < 0.001) than those patients with chronic liver diseases (381 ng/mL, 29-1,688) or of a healthy control group (155 ng/mL, 10-766). Within the HCC patient group, plasma OPN level increased significantly with advancing degree of Child-Pugh class and of tumor stage. Diagnostic sensitivity and specificity of OPN for HCC was 87% and 82%, respectively (cut-off value: 617.6 ng/mL). OPN had a greater area under curve value (0.898) than AFP (0.745) or PIVKA II (0.578), suggesting superior diagnostic accuracy of OPN. Immunohistochemistry of 285 samples of HCC showed that OPN was expressed in 92 of 285 tumors (32.3%). OPN expression was found in the malignant hepatocytes and cancer-infiltrating macrophages, not in the noncancerous hepatocytes or Kupffer cells. CONCLUSIONS: These data propose elevated plasma OPN levels as a potential biomarker for HCC. More... »
PAGESajg2006379
http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00679.x
DOIhttp://dx.doi.org/10.1111/j.1572-0241.2006.00679.x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1051689732
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16848813
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Hepatocellular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diagnosis, Differential",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme-Linked Immunosorbent Assay",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hepatectomy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Osteopontin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Precursors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prothrombin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ROC Curve",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Severity of Illness Index",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sialoglycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "alpha-Fetoproteins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Jin",
"id": "sg:person.0650224564.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650224564.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Ki",
"givenName": "Seung S",
"id": "sg:person.01055663257.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055663257.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Sang D",
"id": "sg:person.01162000362.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162000362.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Han",
"givenName": "Chul J",
"id": "sg:person.0623004755.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623004755.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Departments of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Yu C",
"id": "sg:person.01177262516.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177262516.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Pathology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Departments of Pathology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Sun H",
"id": "sg:person.01007476232.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007476232.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Pathology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Departments of Pathology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Cho",
"givenName": "Soo Y",
"id": "sg:person.0722746465.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722746465.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Laboratory Medicine, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Hong",
"givenName": "Young-Joon",
"id": "sg:person.0657672630.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657672630.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Hyo Y",
"id": "sg:person.01371733634.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371733634.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Myoungjin",
"id": "sg:person.01267003305.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267003305.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Jung",
"givenName": "Ha H",
"id": "sg:person.01335116505.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335116505.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415464.6",
"name": [
"Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-ku, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Kee H",
"id": "sg:person.012770135764.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012770135764.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea",
"id": "http://www.grid.ac/institutes/grid.412480.b",
"name": [
"Department of Internal Medicine, Seoul National University Bundang Hospital, Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea"
],
"type": "Organization"
},
"familyName": "Jeong",
"givenName": "Sook-Hyang",
"id": "sg:person.01311212424.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311212424.28"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/sj.bjc.6601839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019828248",
"https://doi.org/10.1038/sj.bjc.6601839"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1202799",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009708005",
"https://doi.org/10.1038/sj.onc.1202799"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm843",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047937136",
"https://doi.org/10.1038/nm843"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-07-18",
"datePublishedReg": "2006-07-18",
"description": "OBJECTIVES: Osteopontin (OPN) is a secreted glycoprotein, frequently associated with various tumors. We investigated the usefulness of plasma OPN level as a biomarker for hepatocellular carcinoma (HCC).\nMETHODS: We determined plasma levels of OPN, alpha-fetoprotein (AFP), and prothrombin induced by vitamin K absence II (PIVKA II) in a group of 62 HCC patients, in 60 patients with chronic liver diseases, and in 60 healthy control individuals using a standardized ELISA kit. To determine the source of elevated plasma level of OPN, immunohistochemical analysis of 285 HCC samples on tissue microarray was performed.\nRESULTS: Plasma OPN levels in the HCC patients (median 954 ng/mL, range 168-5,742) were significantly higher (p-value < 0.001) than those patients with chronic liver diseases (381 ng/mL, 29-1,688) or of a healthy control group (155 ng/mL, 10-766). Within the HCC patient group, plasma OPN level increased significantly with advancing degree of Child-Pugh class and of tumor stage. Diagnostic sensitivity and specificity of OPN for HCC was 87% and 82%, respectively (cut-off value: 617.6 ng/mL). OPN had a greater area under curve value (0.898) than AFP (0.745) or PIVKA II (0.578), suggesting superior diagnostic accuracy of OPN. Immunohistochemistry of 285 samples of HCC showed that OPN was expressed in 92 of 285 tumors (32.3%). OPN expression was found in the malignant hepatocytes and cancer-infiltrating macrophages, not in the noncancerous hepatocytes or Kupffer cells.\nCONCLUSIONS: These data propose elevated plasma OPN levels as a potential biomarker for HCC.",
"genre": "article",
"id": "sg:pub.10.1111/j.1572-0241.2006.00679.x",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1412991",
"issn": [
"0002-9270",
"1572-0241"
],
"name": "The American Journal of Gastroenterology",
"publisher": "Wolters Kluwer",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "101"
}
],
"keywords": [
"plasma OPN levels",
"chronic liver disease",
"hepatocellular carcinoma",
"OPN levels",
"alpha-fetoprotein",
"liver disease",
"plasma levels",
"HCC patients",
"Elevated Plasma Osteopontin Levels",
"vitamin K absence-II",
"samples of HCC",
"HCC patient group",
"plasma osteopontin levels",
"Child-Pugh class",
"elevated plasma levels",
"healthy control group",
"healthy control individuals",
"elevated plasma OPN levels",
"specificity of osteopontin",
"superior diagnostic accuracy",
"PIVKA-II",
"patient group",
"tumor stage",
"standardized ELISA kit",
"osteopontin levels",
"Kupffer cells",
"tissue microarray",
"immunohistochemical analysis",
"patients",
"control group",
"control individuals",
"potential biomarkers",
"malignant hepatocytes",
"HCC samples",
"ELISA kit",
"diagnostic accuracy",
"OPN expression",
"diagnostic sensitivity",
"curve values",
"noncancerous hepatocytes",
"carcinoma",
"osteopontin",
"tumors",
"disease",
"biomarkers",
"hepatocytes",
"group",
"levels",
"greater area",
"immunohistochemistry",
"macrophages",
"prothrombin",
"kit",
"glycoprotein",
"cells",
"expression",
"microarrays",
"specificity",
"individuals",
"samples",
"sensitivity",
"usefulness",
"stage",
"degree",
"analysis",
"area",
"values",
"class",
"source",
"accuracy"
],
"name": "Elevated Plasma Osteopontin Levels in Patients with Hepatocellular Carcinoma",
"pagination": "ajg2006379",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1051689732"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1111/j.1572-0241.2006.00679.x"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16848813"
]
}
],
"sameAs": [
"https://doi.org/10.1111/j.1572-0241.2006.00679.x",
"https://app.dimensions.ai/details/publication/pub.1051689732"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:24",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_422.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1111/j.1572-0241.2006.00679.x"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00679.x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00679.x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00679.x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00679.x'
This table displays all metadata directly associated to this object as RDF triples.
329 TRIPLES
22 PREDICATES
122 URIs
111 LITERALS
30 BLANK NODES