Relationship Between Pancreatic Secretory Trypsin Inhibitor and Early Recurrence of Intrahepatic Cholangiocarcinoma Following Surgical Resection View Full Text


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Article Info

DATE

2006-07-01

AUTHORS

Akihiko Tonouchi, Masayuki Ohtsuka, Hiroshi Ito, Fumio Kimura, Hiroaki Shimizu, Masaki Kato, Yoshinori Nimura, Katsuro Iwase, Takaki Hiwasa, Naohiko Seki, Masaki Takiguchi, Masaru Miyazaki

ABSTRACT

OBJECTIVES: The extremely unfavorable prognosis of intrahepatic cholangiocarcinoma (ICC), even after surgical resection, is mainly attributed to a high rate of recurrence. The aim of this study was to identify the molecules associated with early recurrence of ICC following resection. METHODS: Between December 1984 and July 2003, 46 patients with ICC underwent surgical resection. The clinical outcome of these patients was evaluated in view of the time of recurrence. Consequently, we categorized ICC patients into subgroups, based on the clinical results, and screened differentially expressed genes by DNA microarray analysis. Furthermore, the obtained results were validated in an independent sample set by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemistry was performed to assess the expressed genes at the protein level. RESULTS: The survival of patients with early recurrence, occurring within a year after surgical resection, was significantly poor after surgery and even after recurrence, as compared to that of patients whose recurrence occurred beyond a year after surgery. By the DNA microarray analysis, 13 differentially expressed genes were picked up, and quantitative RT-PCR reaction identified the pancreatic secretory trypsin inhibitor (PSTI) as a candidate gene associated with early recurrence of ICC after resection. This observation was confirmed through examination of an independent set of samples, in which the patients with higher levels of PSTI mRNA expression had significantly shorter recurrence-free survival. Immunohistochemically, PSTI was expressed in the cytoplasm of cancer cells. CONCLUSIONS: PSTI might be a potential marker for identifying ICC patients with an increased risk of early recurrence after surgical resection. More... »

PAGES

ajg2006297

References to SciGraph publications

  • 1985-03. Are hepatolithiasis and cholangiocarcinoma aetiologically related? in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 2002-07-15. Gene-expression profiles predict survival of patients with lung adenocarcinoma in NATURE MEDICINE
  • 1998-04. Surgical management of intrahepatic cholangiocarcinoma: A 31-year experience in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2001-04. Recurrence after surgical resection of intrahepatic cholangiocarcinoma in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2006.00612.x

    DOI

    http://dx.doi.org/10.1111/j.1572-0241.2006.00612.x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033432619

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16863567


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