A Randomized Control Trial of Bimonthly Versus Biweekly Endoscopic Variceal Ligation of Esophageal Varices View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-09-01

AUTHORS

Hiroshi Yoshida, Yasuhiro Mamada, Nobuhiko Taniai, Kazuhito Yamamoto, Youichi Kawano, Yoshiaki Mizuguchi, Tetsuya Shimizu, Tsubasa Takahashi, Takashi Tajiri

ABSTRACT

Endoscopic variceal ligation (EVL) is a safe and simple procedure now being used on a widening scale. Yet most patients who undergo endoscopic treatment for esophageal varices eventually require additional treatment for recurrent varices. In this study, we investigated and compared the efficacy and long-term results of EVL performed in three treatments with a total of sixteen O-rings at two different intervals; bi-weekly (once every 2 wk: the conventional interval) and bi-monthly (once every 2 months). A total of 63 patients with esophageal varices were randomly assigned to groups receiving bi-weekly or bi-monthly EVL treatment. Optimal medical therapy was assessed by one medical doctor who was unaware of the patients' treatment assignments. Three parameters of treatment outcome were evaluated: the rate of recurrence, rate of additional treatment, and overall survival. The overall rates of variceal recurrence and additional treatment were both higher in the bi-weekly group than in the bi-monthly group (p < 0.001). In conclusion, EVL performed for the treatment of esophageal varices at bi-monthly intervals brought about better results than the same treatment performed at bi-weekly intervals. The treatments intercalated by the longer interval obtained a higher total eradication rate, lower recurrence rate, and lower rate of additional treatment. More... »

PAGES

ajg2005360

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2005.41864.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2005.41864.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001851668

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16128945


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