Proton-Pump Inhibitors and Outcome of Endoscopic Hemostasis in Bleeding Peptic Ulcers: A Series of Meta-analyses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-01-01

AUTHORS

A Andriulli, V Annese, N Caruso, A Pilotto, L Accadia, AG Niro, M Quitadamo, A Merla, S Fiorella, G Leandro

ABSTRACT

OBJECTIVE: To perform meta-analyses of studies on outcome of bleeding ulcers of different proton-pump inhibitors (PPIs) regimens, after stratification of patients by endoscopic stigmata, and analysis of studies with and without endotherapy. METHODS: A total of 35 randomized trials comparing PPIs to placebo and/or H2-receptor antagonists (H2RAs) in 4,843 patients with high-risk endoscopic stigmata were retrieved. Outcomes were rebleeding, surgery, and mortality. RESULTS: Monotherapy with oral or bolus PPIs was superior to placebo and H2RAs in reducing rebleeding in both bleeders and nonbleeders at index endoscopy; the need for surgery was reduced only when compared to H2RAs. In nonbleeders, PPI monotherapy was as effective as a combination of endotherapy with H2RAs. A combination of endotherapy with PPIs was superior to monotherapy in reducing bleeding and surgery, and superior to endotherapy alone in minimizing rebleeding, but not surgery; the benefit was lost when confronted to endotherapy plus H2RAs, whether PPIs were given as infusion or bolus. By pooling data from studies comparing high doses of PPIs as continuous infusion versus regular doses as intermittent bolus, rebleeding, surgery, and mortality were not significantly different. CONCLUSIONS: Combination of endotherapy with either PPIs or H2RAs is indicated for nonbleeding ulcers at endoscopy with the intent to reduce rebleeding and surgery. Its value may extend to bleeding lesions, but current data are scanty. The benefit appears to be independent from route and doses of PPIs, as oral, bolus, or infusional methods are all effective. More... »

PAGES

ajg200532

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2005.40636.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2005.40636.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044931922

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15654802


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Ulcer Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemostasis, Endoscopic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histamine H2 Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptic Ulcer Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proton Pump Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andriulli", 
        "givenName": "A", 
        "id": "sg:person.0731565272.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731565272.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Annese", 
        "givenName": "V", 
        "id": "sg:person.0655214656.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655214656.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caruso", 
        "givenName": "N", 
        "id": "sg:person.01155725156.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155725156.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pilotto", 
        "givenName": "A", 
        "id": "sg:person.01002377430.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002377430.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Accadia", 
        "givenName": "L", 
        "id": "sg:person.01254611251.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254611251.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niro", 
        "givenName": "AG", 
        "id": "sg:person.0604046712.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604046712.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quitadamo", 
        "givenName": "M", 
        "id": "sg:person.0745231700.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745231700.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Merla", 
        "givenName": "A", 
        "id": "sg:person.0645773626.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645773626.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fiorella", 
        "givenName": "S", 
        "id": "sg:person.01273521326.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273521326.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Divisions of Gastroenterology and Geriatrics, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, \u201cC. De Bellis\u201d Hospital, IRCCS, Castellana Grotte, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leandro", 
        "givenName": "G", 
        "id": "sg:person.01116626030.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116626030.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/j.1572-0241.2002.05780.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037971450", 
          "https://doi.org/10.1111/j.1572-0241.2002.05780.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1998.00590.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061946686", 
          "https://doi.org/10.1111/j.1572-0241.1998.00590.x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-01-01", 
    "datePublishedReg": "2005-01-01", 
    "description": "OBJECTIVE: To perform meta-analyses of studies on outcome of bleeding ulcers of different proton-pump inhibitors (PPIs) regimens, after stratification of patients by endoscopic stigmata, and analysis of studies with and without endotherapy.\nMETHODS: A total of 35 randomized trials comparing PPIs to placebo and/or H2-receptor antagonists (H2RAs) in 4,843 patients with high-risk endoscopic stigmata were retrieved. Outcomes were rebleeding, surgery, and mortality.\nRESULTS: Monotherapy with oral or bolus PPIs was superior to placebo and H2RAs in reducing rebleeding in both bleeders and nonbleeders at index endoscopy; the need for surgery was reduced only when compared to H2RAs. In nonbleeders, PPI monotherapy was as effective as a combination of endotherapy with H2RAs. A combination of endotherapy with PPIs was superior to monotherapy in reducing bleeding and surgery, and superior to endotherapy alone in minimizing rebleeding, but not surgery; the benefit was lost when confronted to endotherapy plus H2RAs, whether PPIs were given as infusion or bolus. By pooling data from studies comparing high doses of PPIs as continuous infusion versus regular doses as intermittent bolus, rebleeding, surgery, and mortality were not significantly different.\nCONCLUSIONS: Combination of endotherapy with either PPIs or H2RAs is indicated for nonbleeding ulcers at endoscopy with the intent to reduce rebleeding and surgery. Its value may extend to bleeding lesions, but current data are scanty. The benefit appears to be independent from route and doses of PPIs, as oral, bolus, or infusional methods are all effective.", 
    "genre": "article", 
    "id": "sg:pub.10.1111/j.1572-0241.2005.40636.x", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019809", 
        "issn": [
          "0002-9270", 
          "1572-0241"
        ], 
        "name": "The American Journal of Gastroenterology", 
        "publisher": "Wolters Kluwer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "100"
      }
    ], 
    "keywords": [
      "endoscopic stigmata", 
      "high-risk endoscopic stigmata", 
      "doses of PPIs", 
      "proton pump inhibitors", 
      "stratification of patients", 
      "H2-receptor antagonists", 
      "inhibitor regimens", 
      "PPI monotherapy", 
      "intermittent bolus", 
      "index endoscopy", 
      "endoscopic hemostasis", 
      "randomized trials", 
      "peptic ulcer", 
      "continuous infusion", 
      "regular doses", 
      "H2RAs", 
      "endotherapy", 
      "surgery", 
      "high doses", 
      "Meta-Analysis", 
      "monotherapy", 
      "ulcers", 
      "bolus", 
      "doses", 
      "nonbleeders", 
      "patients", 
      "analysis of studies", 
      "endoscopy", 
      "infusion", 
      "outcomes", 
      "mortality", 
      "current data", 
      "PPI", 
      "rebleeding", 
      "placebo", 
      "stigma", 
      "bleeding", 
      "regimens", 
      "antagonist", 
      "lesions", 
      "bleeders", 
      "hemostasis", 
      "trials", 
      "study", 
      "total", 
      "inhibitors", 
      "benefits", 
      "combination", 
      "stratification", 
      "data", 
      "intent", 
      "need", 
      "analysis", 
      "series", 
      "route", 
      "values", 
      "method", 
      "different proton-pump inhibitors (PPIs) regimens", 
      "proton-pump inhibitors (PPIs) regimens", 
      "bolus PPIs", 
      "combination of endotherapy", 
      "infusional methods"
    ], 
    "name": "Proton-Pump Inhibitors and Outcome of Endoscopic Hemostasis in Bleeding Peptic Ulcers: A Series of Meta-analyses", 
    "pagination": "ajg200532", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044931922"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1572-0241.2005.40636.x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15654802"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1572-0241.2005.40636.x", 
      "https://app.dimensions.ai/details/publication/pub.1044931922"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_409.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1111/j.1572-0241.2005.40636.x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2005.40636.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2005.40636.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2005.40636.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2005.40636.x'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      22 PREDICATES      98 URIs      88 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1572-0241.2005.40636.x schema:about N1ac088b2bf084a8ea9e6bda863df6a8c
2 N30406075a4ac462183d1a0764aa7f534
3 N36871f7a105f4c759176cf01d41c55e7
4 N3c588e691ebc44918417541092b3dcd5
5 N5b9daea4267e4340b4d50645d91947f6
6 N98db57f0a76342609daf03990e23c1f8
7 Na8c024277f634fd681bb5e0f428f8c11
8 Nc8ef2e0edd3246fd953cb70805eab26d
9 anzsrc-for:11
10 anzsrc-for:1103
11 schema:author Nee5471edf90d41f1b74360be9fc384c4
12 schema:citation sg:pub.10.1111/j.1572-0241.1998.00590.x
13 sg:pub.10.1111/j.1572-0241.2002.05780.x
14 schema:datePublished 2005-01-01
15 schema:datePublishedReg 2005-01-01
16 schema:description OBJECTIVE: To perform meta-analyses of studies on outcome of bleeding ulcers of different proton-pump inhibitors (PPIs) regimens, after stratification of patients by endoscopic stigmata, and analysis of studies with and without endotherapy. METHODS: A total of 35 randomized trials comparing PPIs to placebo and/or H2-receptor antagonists (H2RAs) in 4,843 patients with high-risk endoscopic stigmata were retrieved. Outcomes were rebleeding, surgery, and mortality. RESULTS: Monotherapy with oral or bolus PPIs was superior to placebo and H2RAs in reducing rebleeding in both bleeders and nonbleeders at index endoscopy; the need for surgery was reduced only when compared to H2RAs. In nonbleeders, PPI monotherapy was as effective as a combination of endotherapy with H2RAs. A combination of endotherapy with PPIs was superior to monotherapy in reducing bleeding and surgery, and superior to endotherapy alone in minimizing rebleeding, but not surgery; the benefit was lost when confronted to endotherapy plus H2RAs, whether PPIs were given as infusion or bolus. By pooling data from studies comparing high doses of PPIs as continuous infusion versus regular doses as intermittent bolus, rebleeding, surgery, and mortality were not significantly different. CONCLUSIONS: Combination of endotherapy with either PPIs or H2RAs is indicated for nonbleeding ulcers at endoscopy with the intent to reduce rebleeding and surgery. Its value may extend to bleeding lesions, but current data are scanty. The benefit appears to be independent from route and doses of PPIs, as oral, bolus, or infusional methods are all effective.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf N577f9db50d5a43e291276b95f191bf10
21 N7b5a838d3508428d863b438c9909f09d
22 sg:journal.1019809
23 schema:keywords H2-receptor antagonists
24 H2RAs
25 Meta-Analysis
26 PPI
27 PPI monotherapy
28 analysis
29 analysis of studies
30 antagonist
31 benefits
32 bleeders
33 bleeding
34 bolus
35 bolus PPIs
36 combination
37 combination of endotherapy
38 continuous infusion
39 current data
40 data
41 different proton-pump inhibitors (PPIs) regimens
42 doses
43 doses of PPIs
44 endoscopic hemostasis
45 endoscopic stigmata
46 endoscopy
47 endotherapy
48 hemostasis
49 high doses
50 high-risk endoscopic stigmata
51 index endoscopy
52 infusion
53 infusional methods
54 inhibitor regimens
55 inhibitors
56 intent
57 intermittent bolus
58 lesions
59 method
60 monotherapy
61 mortality
62 need
63 nonbleeders
64 outcomes
65 patients
66 peptic ulcer
67 placebo
68 proton pump inhibitors
69 proton-pump inhibitors (PPIs) regimens
70 randomized trials
71 rebleeding
72 regimens
73 regular doses
74 route
75 series
76 stigma
77 stratification
78 stratification of patients
79 study
80 surgery
81 total
82 trials
83 ulcers
84 values
85 schema:name Proton-Pump Inhibitors and Outcome of Endoscopic Hemostasis in Bleeding Peptic Ulcers: A Series of Meta-analyses
86 schema:pagination ajg200532
87 schema:productId N2e5152ba2c5d4bbc8a8b8bd1564ed068
88 Na3c49615d04c43a4af4a0e47ca2973e0
89 Nf897aa69c27d495cb745dc510485e4b8
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044931922
91 https://doi.org/10.1111/j.1572-0241.2005.40636.x
92 schema:sdDatePublished 2022-01-01T18:15
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Neb39dc85c3d7434d8920e3893f35557e
95 schema:url https://doi.org/10.1111/j.1572-0241.2005.40636.x
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N1ac088b2bf084a8ea9e6bda863df6a8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Proton Pump Inhibitors
101 rdf:type schema:DefinedTerm
102 N25ab7223b14d491397fa74fa2966ab09 rdf:first sg:person.0745231700.97
103 rdf:rest N8990f12206c1453aac3b372254751965
104 N2e5152ba2c5d4bbc8a8b8bd1564ed068 schema:name doi
105 schema:value 10.1111/j.1572-0241.2005.40636.x
106 rdf:type schema:PropertyValue
107 N30406075a4ac462183d1a0764aa7f534 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Histamine H2 Antagonists
109 rdf:type schema:DefinedTerm
110 N36871f7a105f4c759176cf01d41c55e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Hemostasis, Endoscopic
112 rdf:type schema:DefinedTerm
113 N3c588e691ebc44918417541092b3dcd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Peptic Ulcer Hemorrhage
115 rdf:type schema:DefinedTerm
116 N419216258d0f4d58ac400f19065d45fd rdf:first sg:person.01254611251.28
117 rdf:rest Nf382cbb7add14803acca59ab276d6e9e
118 N577f9db50d5a43e291276b95f191bf10 schema:volumeNumber 100
119 rdf:type schema:PublicationVolume
120 N5b9daea4267e4340b4d50645d91947f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 N7b0d9564bca34ae3a5dccbffafbed344 rdf:first sg:person.01155725156.00
124 rdf:rest Nfb6f9bdb2ddc4c369a9a1555cfeda062
125 N7b5a838d3508428d863b438c9909f09d schema:issueNumber 1
126 rdf:type schema:PublicationIssue
127 N87be720ea2094303910a1359aaed5eb6 rdf:first sg:person.01273521326.11
128 rdf:rest Ndd5ba676ec914d01965485a2d683962b
129 N8990f12206c1453aac3b372254751965 rdf:first sg:person.0645773626.19
130 rdf:rest N87be720ea2094303910a1359aaed5eb6
131 N90139f6ff7a94d029f78562a49e1cafd rdf:first sg:person.0655214656.73
132 rdf:rest N7b0d9564bca34ae3a5dccbffafbed344
133 N98db57f0a76342609daf03990e23c1f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Treatment Outcome
135 rdf:type schema:DefinedTerm
136 Na3c49615d04c43a4af4a0e47ca2973e0 schema:name dimensions_id
137 schema:value pub.1044931922
138 rdf:type schema:PropertyValue
139 Na8c024277f634fd681bb5e0f428f8c11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Combined Modality Therapy
141 rdf:type schema:DefinedTerm
142 Nc8ef2e0edd3246fd953cb70805eab26d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Anti-Ulcer Agents
144 rdf:type schema:DefinedTerm
145 Ndd5ba676ec914d01965485a2d683962b rdf:first sg:person.01116626030.88
146 rdf:rest rdf:nil
147 Neb39dc85c3d7434d8920e3893f35557e schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 Nee5471edf90d41f1b74360be9fc384c4 rdf:first sg:person.0731565272.40
150 rdf:rest N90139f6ff7a94d029f78562a49e1cafd
151 Nf382cbb7add14803acca59ab276d6e9e rdf:first sg:person.0604046712.14
152 rdf:rest N25ab7223b14d491397fa74fa2966ab09
153 Nf897aa69c27d495cb745dc510485e4b8 schema:name pubmed_id
154 schema:value 15654802
155 rdf:type schema:PropertyValue
156 Nfb6f9bdb2ddc4c369a9a1555cfeda062 rdf:first sg:person.01002377430.05
157 rdf:rest N419216258d0f4d58ac400f19065d45fd
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
162 schema:name Clinical Sciences
163 rdf:type schema:DefinedTerm
164 sg:journal.1019809 schema:issn 0002-9270
165 1572-0241
166 schema:name The American Journal of Gastroenterology
167 schema:publisher Wolters Kluwer
168 rdf:type schema:Periodical
169 sg:person.01002377430.05 schema:affiliation grid-institutes:None
170 schema:familyName Pilotto
171 schema:givenName A
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002377430.05
173 rdf:type schema:Person
174 sg:person.01116626030.88 schema:affiliation grid-institutes:None
175 schema:familyName Leandro
176 schema:givenName G
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116626030.88
178 rdf:type schema:Person
179 sg:person.01155725156.00 schema:affiliation grid-institutes:None
180 schema:familyName Caruso
181 schema:givenName N
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155725156.00
183 rdf:type schema:Person
184 sg:person.01254611251.28 schema:affiliation grid-institutes:None
185 schema:familyName Accadia
186 schema:givenName L
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254611251.28
188 rdf:type schema:Person
189 sg:person.01273521326.11 schema:affiliation grid-institutes:None
190 schema:familyName Fiorella
191 schema:givenName S
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273521326.11
193 rdf:type schema:Person
194 sg:person.0604046712.14 schema:affiliation grid-institutes:None
195 schema:familyName Niro
196 schema:givenName AG
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604046712.14
198 rdf:type schema:Person
199 sg:person.0645773626.19 schema:affiliation grid-institutes:None
200 schema:familyName Merla
201 schema:givenName A
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645773626.19
203 rdf:type schema:Person
204 sg:person.0655214656.73 schema:affiliation grid-institutes:None
205 schema:familyName Annese
206 schema:givenName V
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655214656.73
208 rdf:type schema:Person
209 sg:person.0731565272.40 schema:affiliation grid-institutes:None
210 schema:familyName Andriulli
211 schema:givenName A
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731565272.40
213 rdf:type schema:Person
214 sg:person.0745231700.97 schema:affiliation grid-institutes:None
215 schema:familyName Quitadamo
216 schema:givenName M
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745231700.97
218 rdf:type schema:Person
219 sg:pub.10.1111/j.1572-0241.1998.00590.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1061946686
220 https://doi.org/10.1111/j.1572-0241.1998.00590.x
221 rdf:type schema:CreativeWork
222 sg:pub.10.1111/j.1572-0241.2002.05780.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037971450
223 https://doi.org/10.1111/j.1572-0241.2002.05780.x
224 rdf:type schema:CreativeWork
225 grid-institutes:None schema:alternateName Divisions of Gastroenterology and Geriatrics, “Casa Sollievo della Sofferenza” Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, “C. De Bellis” Hospital, IRCCS, Castellana Grotte, Italy
226 schema:name Divisions of Gastroenterology and Geriatrics, “Casa Sollievo della Sofferenza” Hospital, IRCCS, San Giovanni Rotondo, Italy; and Division of Gastroenterology, “C. De Bellis” Hospital, IRCCS, Castellana Grotte, Italy
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...