Feasibility and Diagnostic Utility of Video Capsule Endoscopy for the Detection of Small Bowel Polyps in Patients with Hereditary Polyposis ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-01

AUTHORS

Karsten Schulmann, Stephan Hollerbach, Katja Kraus, Jörg Willert, Tilman Vogel, Gabriela Möslein, Christian Pox, Markus Reiser, Anke Reinacher-Schick, Wolff Schmiegel

ABSTRACT

OBJECTIVES: At present, surveillance of premalignant small bowel polyps in hereditary polyposis syndromes has a number of limitations. Capsule endoscopy (CE) is a promising new method to endoscopically assess the entire length of the small bowel. METHODS: We prospectively examined 40 patients with hereditary polyposis syndromes (29 familial adenomatous polyposis (FAP), 11 Peutz-Jeghers syndrome (PJS)). Results were compared with push-enteroscopy (PE) results in FAP and with esophagogastroduodenoscopy, PE, (MR)-enteroclysis, and surgical specimen in PJS patients. RESULTS: A total of 76% of the patients with FAP with duodenal adenomas (n = 21) had additional adenomas in the proximal jejunum that could be detected by CE and PE. Moreover, 24% of these FAP patients had further polyps in the distal jejunum or ileum that could only be detected by CE. In contrast, in FAP patients without duodenal polyps (n = 8), jejunal or ileal polyps occurred rarely (12%). CE detected polyps in 10 of 11 patients with PJS, a rate superior to all other reference procedures employed. Importantly, the findings of CE had immediate impact on further clinical management in all PJS patients. CONCLUSIONS: Our results suggest that CE may be of clinical value in selected patients with FAP, whereas in PJS, CE could be used as first line surveillance procedure. More... »

PAGES

ajg20057

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2005.40102.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2005.40102.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007258858

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15654777


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