Macrocystic form of serous pancreatic cystadenoma View Full Text


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Article Info

DATE

2002-10-01

AUTHORS

Denis Chatelain, Pascal Hammel, Dermot O'Toole, Benoît Terris, Valérie Vilgrain, Laurent Palazzo, Jacques Belghiti, Philippe Lévy, Philippe Ruszniewski, Jean-François Fléjou

ABSTRACT

OBJECTIVES: Macrocystic serous cystadenoma of the pancreas are benign lesions with sometimes difficult diagnostic issues. We aimed to describe clinicopathological and imaging features with cyst fluid analysis in a series of patients undergoing surgery for macrocystic serous cystadenoma. METHODS: Eight patients underwent pancreatic resection for a macrocystic lesion of the pancreas diagnosed on ultrasonography or CT. Endoscopic ultrasonography and preoperative fine-needle aspiration were performed in seven patients. Immunohistochemical analysis of the surgical specimen with antibodies to carcinoembryonic-antigen (CEA), carbohydrate antigen (CA) 19-9, estrogen receptor, and progesterone receptor antibodies was performed in all cases. RESULTS: Patients included seven women and one man, with a mean age of 48 yr. Lesions were incidentally discovered on ultrasonography in six patients and had a mean size of 3 cm (range, 1.5-5 cm). Endoscopic ultrasonography revealed millimetric cysts in three cases. In the seven aspirated cysts, cytological analysis was non-contributive, but biochemical analysis showed low content of CEA (< 5 ng/ml) and CA72.4 (< 40U/ml) in all but two. At histology, cysts were lined by clear cuboidal cells. They focally expressed CA19-9 but were negative for anti-CEA, antiestrogen receptor, and antiprogesterone receptor antibodies. Microscopic cysts in the wall of the lesions were demonstrated in five cases. CONCLUSIONS: Macrocystic serous cystadenoma is a particular variant of pancreatic serous cystadenoma. Endoscopic ultrasonography may be useful in detecting peripherally located millimetric cysts in unilocular lesions, and measurement of enzymes and tumor markers in cyst fluid may also contribute to the diagnosis showing low concentrations. More... »

PAGES

ajg2002653

References to SciGraph publications

  • 1995-02. A case of macrocystic serous cystadenoma of the pancreas in JOURNAL OF GASTROINTESTINAL CANCER
  • 1999-01. Macrocystic serous cystadenoma of the pancreas:CT and endosonographic features in ABDOMINAL RADIOLOGY
  • 1998-09. Quiz case of the month in EUROPEAN RADIOLOGY
  • 2000-08. Macrocystic serous cystadenoma of the pancreas in JOURNAL OF GASTROINTESTINAL CANCER
  • 2000-03. Macrocystic serous cystadenoma of the pancreas in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 1995-10. Solitary true cyst of the pancreas in adults in JOURNAL OF GASTROINTESTINAL CANCER
  • 2000-06. Macrocystic serous cystadenoma of the pancreas: importance of co-existent tiny cysts depicted by EUS in JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2002.06024.x

    DOI

    http://dx.doi.org/10.1111/j.1572-0241.2002.06024.x

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12385440


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    25 schema:description OBJECTIVES: Macrocystic serous cystadenoma of the pancreas are benign lesions with sometimes difficult diagnostic issues. We aimed to describe clinicopathological and imaging features with cyst fluid analysis in a series of patients undergoing surgery for macrocystic serous cystadenoma. METHODS: Eight patients underwent pancreatic resection for a macrocystic lesion of the pancreas diagnosed on ultrasonography or CT. Endoscopic ultrasonography and preoperative fine-needle aspiration were performed in seven patients. Immunohistochemical analysis of the surgical specimen with antibodies to carcinoembryonic-antigen (CEA), carbohydrate antigen (CA) 19-9, estrogen receptor, and progesterone receptor antibodies was performed in all cases. RESULTS: Patients included seven women and one man, with a mean age of 48 yr. Lesions were incidentally discovered on ultrasonography in six patients and had a mean size of 3 cm (range, 1.5-5 cm). Endoscopic ultrasonography revealed millimetric cysts in three cases. In the seven aspirated cysts, cytological analysis was non-contributive, but biochemical analysis showed low content of CEA (< 5 ng/ml) and CA72.4 (< 40U/ml) in all but two. At histology, cysts were lined by clear cuboidal cells. They focally expressed CA19-9 but were negative for anti-CEA, antiestrogen receptor, and antiprogesterone receptor antibodies. Microscopic cysts in the wall of the lesions were demonstrated in five cases. CONCLUSIONS: Macrocystic serous cystadenoma is a particular variant of pancreatic serous cystadenoma. Endoscopic ultrasonography may be useful in detecting peripherally located millimetric cysts in unilocular lesions, and measurement of enzymes and tumor markers in cyst fluid may also contribute to the diagnosis showing low concentrations.
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    71 immunohistochemical analysis
    72 issues
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    81 measurement of enzymes
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