Pantoprazole therapy in the long-term management of severe acid peptic disease Clinical efficacy, safety, serum gastrin, gastric histology, and endocrine ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-06-01

AUTHORS

Karna Dev Bardhan, Pradip Cherian, Anne E Bishop, Julia M Polak, H Romanska, Michael J Perry, Anne Rowland, Mary Thompson, Pamela Morris, Andreas Schneider, Renata Fischer, W Ng, R Lühmann, Brian McCaldin

ABSTRACT

OBJECTIVE: Pantoprazole is the third proton pump inhibitor to become available. When this study was started, there were few data on its long-term use. Our aim was to investigate this aspect and, because powerful inhibitors of acid secretion can cause hypergastrinemia and, in experimental animals, enterochromaffin-like cell hyperplasia, we also monitored serum gastrin and endocrine cell histology. METHODS: One hundred fifty patients refractory to H2-receptor antagonists, running an aggressive course or with complications, were entered into a 5-yr treatment program. We performed serial endoscopy, checked for adverse events, and laboratory values. We also monitored serum gastrin, gastric endocrine cell histology, and antral and corpus gastritis. RESULTS: This report presents results from up to 3 yr of treatment. Cumulative healing on 40-80 mg of pantoprazole was 82% at 4 wk and 92% by 12 wk. Most patients became asymptomatic within 4 wk. Remission on maintenance treatment with 40 mg (n = 111) was 85% at 12 months and 78% at 24 months. Treatment was safe; only four patients had adverse events definitely related to pantoprazole. Elevations in gastrin were modest and there were no significant changes in gastric endocrine cells. The number of enterochromaffin-like cells tended to decrease. CONCLUSION: Pantoprazole is effective, safe, and does not seem to be associated with large increases in serum gastrin or alterations in gastric endocrine cells. More... »

PAGES

ajg2001434

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2001.03185.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2001.03185.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004796999

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11419827


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31 schema:description OBJECTIVE: Pantoprazole is the third proton pump inhibitor to become available. When this study was started, there were few data on its long-term use. Our aim was to investigate this aspect and, because powerful inhibitors of acid secretion can cause hypergastrinemia and, in experimental animals, enterochromaffin-like cell hyperplasia, we also monitored serum gastrin and endocrine cell histology. METHODS: One hundred fifty patients refractory to H2-receptor antagonists, running an aggressive course or with complications, were entered into a 5-yr treatment program. We performed serial endoscopy, checked for adverse events, and laboratory values. We also monitored serum gastrin, gastric endocrine cell histology, and antral and corpus gastritis. RESULTS: This report presents results from up to 3 yr of treatment. Cumulative healing on 40-80 mg of pantoprazole was 82% at 4 wk and 92% by 12 wk. Most patients became asymptomatic within 4 wk. Remission on maintenance treatment with 40 mg (n = 111) was 85% at 12 months and 78% at 24 months. Treatment was safe; only four patients had adverse events definitely related to pantoprazole. Elevations in gastrin were modest and there were no significant changes in gastric endocrine cells. The number of enterochromaffin-like cells tended to decrease. CONCLUSION: Pantoprazole is effective, safe, and does not seem to be associated with large increases in serum gastrin or alterations in gastric endocrine cells.
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38 schema:keywords H2-receptor antagonists
39 acid peptic disease Clinical efficacy
40 acid secretion
41 adverse events
42 aggressive course
43 aim
44 alterations
45 animals
46 antagonist
47 antral
48 aspects
49 cell histology
50 cell hyperplasia
51 cell studies
52 cells
53 changes
54 clinical efficacy
55 complications
56 corpus gastritis
57 course
58 cumulative healing
59 data
60 disease Clinical efficacy
61 efficacy
62 elevation
63 endocrine cell histology
64 endocrine cell studies
65 endocrine cells
66 endoscopy
67 enterochromaffin-like cell hyperplasia
68 enterochromaffin-like cells
69 events
70 experimental animals
71 gastric endocrine cell histology
72 gastric endocrine cells
73 gastric histology
74 gastrin
75 gastritis
76 healing
77 histology
78 hypergastrinemia
79 hyperplasia
80 increase
81 inhibitors
82 laboratory values
83 large increase
84 long-term management
85 long-term use
86 maintenance treatment
87 management
88 months
89 most patients
90 number
91 pantoprazole
92 pantoprazole therapy
93 patients
94 peptic disease Clinical efficacy
95 powerful inhibitor
96 program
97 proton pump inhibitors
98 pump inhibitors
99 remission
100 report
101 results
102 safety
103 secretion
104 serial endoscopy
105 serum gastrin
106 severe acid peptic disease Clinical efficacy
107 significant changes
108 study
109 therapy
110 third proton pump inhibitor
111 treatment
112 treatment program
113 use
114 values
115 wk
116 yr
117 yr of treatment
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