Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-09

AUTHORS

Henrik Toft Sørensen, Lene Mellemkjær, William J Blot, Gunnar Lauge Nielsen, Flemming Hald Steffensen, Joseph K McLaughlin, Jørgen H Olsen

ABSTRACT

OBJECTIVE: Aspirin products are known to cause irritation and injury to the gastric mucosa. We examined the risk of hospitalization for upper gastrointestinal bleeding with use of low-dose aspirin. METHODS: This was a cohort study based on record linkage between a population-based prescription database and a hospital discharge registry in North Jutland County, Denmark, from January 1, 1991, to December 31, 1995. Incidence rates of upper gastrointestinal bleeding in 27,694 users of low-dose aspirin were compared with the incidence rates in the general population in the county. RESULTS: A total of 207 exclusive users of low-dose aspirin experienced a first episode of upper gastrointestinal bleeding with admission to the hospital during the study period. The standardized incidence rate ratio was 2.6 (95% confidence interval, 2.2-2.9), 2.3 in women and 2.8 in men. The standardized incidence rate ratio for combined use of low-dose aspirin and other nonsteroidal anti-inflammatory drugs was 5.6 (95% confidence interval, 4.4-7.0). The risk was similar among users of noncoated low-dose aspirin (standardized incidence rate ratio, 2.6; 95% confidence interval, 1.8-3.5) and coated low-dose aspirin (standardized incidence rate ratio, 2.6; 95% confidence interval, 2.2-3.0). CONCLUSIONS: Use of low-dose aspirin was associated with an increased risk of upper gastrointestinal bleeding, with still higher risks when combined with other nonsteroidal anti-inflammatory drugs. Enteric coating did not seem to reduce the risk. The findings from this observational study raise the possibility that prophylactic use of low-dose aspirin may convey an increased risk of gastrointestinal bleeding, which may offset some of its benefits. More... »

PAGES

ajg2000570

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02248.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2000.02248.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003405193

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11007221


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents, Non-Steroidal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspirin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Confidence Intervals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Denmark", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnosis, Differential", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nonprescription Drugs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "Department of Clinical Epidemiology, Aarhus University and Aalborg Hospitals, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00f8rensen", 
        "givenName": "Henrik Toft", 
        "id": "sg:person.015362420175.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015362420175.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danish Cancer Society", 
          "id": "https://www.grid.ac/institutes/grid.417390.8", 
          "name": [
            "The Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mellemkj\u00e6r", 
        "givenName": "Lene", 
        "id": "sg:person.01224434067.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224434067.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Epidemiology Institute", 
          "id": "https://www.grid.ac/institutes/grid.419344.f", 
          "name": [
            "The International Epidemiology Institute, Rockville, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blot", 
        "givenName": "William J", 
        "id": "sg:person.01236726331.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236726331.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aalborg Hospital", 
          "id": "https://www.grid.ac/institutes/grid.27530.33", 
          "name": [
            "The Department of Medicine M, Aalborg Hospital, Aalborg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nielsen", 
        "givenName": "Gunnar Lauge", 
        "id": "sg:person.01030775563.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030775563.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steffensen", 
        "givenName": "Flemming Hald", 
        "id": "sg:person.0637111572.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637111572.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "International Epidemiology Institute", 
          "id": "https://www.grid.ac/institutes/grid.419344.f", 
          "name": [
            "The International Epidemiology Institute, Rockville, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McLaughlin", 
        "givenName": "Joseph K", 
        "id": "sg:person.012525351037.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525351037.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danish Cancer Society", 
          "id": "https://www.grid.ac/institutes/grid.417390.8", 
          "name": [
            "The Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olsen", 
        "givenName": "J\u00f8rgen H", 
        "id": "sg:person.016011671300.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016011671300.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)11475-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000802716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0895-4356(88)90007-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001575625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.296.6618.307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003351315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)04311-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008729184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)92233-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008744960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)92233-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008744960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018832902287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009378226", 
          "https://doi.org/10.1023/a:1018832902287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)76185-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016667682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.297.6659.1311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017641277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1993.tb05689.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019997851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.1993.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023293498", 
          "https://doi.org/10.1038/clpt.1993.55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)01254-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027052083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-4356(99)00004-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032838571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.1994.tb00271.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036068723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198007173030305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038980827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1997.tb00023.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046089208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)91843-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046185961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)91843-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046185961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(80)90282-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046507171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(80)90282-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046507171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1991.tb05616.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046712815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)92336-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049813580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)92336-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049813580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(89)91200-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052649741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.148.2.281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054111924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.310.6983.827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062771415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.310.6983.827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062771415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.311.6999.222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062772688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.311.6999.222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062772688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7107.510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7107.510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062780601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7119.1333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062781362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7119.1333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062781362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1656307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076838836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jrs-1997-10101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078705511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jrs-1997-10309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078705562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083187895", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-09", 
    "datePublishedReg": "2000-09-01", 
    "description": "OBJECTIVE: Aspirin products are known to cause irritation and injury to the gastric mucosa. We examined the risk of hospitalization for upper gastrointestinal bleeding with use of low-dose aspirin.\nMETHODS: This was a cohort study based on record linkage between a population-based prescription database and a hospital discharge registry in North Jutland County, Denmark, from January 1, 1991, to December 31, 1995. Incidence rates of upper gastrointestinal bleeding in 27,694 users of low-dose aspirin were compared with the incidence rates in the general population in the county.\nRESULTS: A total of 207 exclusive users of low-dose aspirin experienced a first episode of upper gastrointestinal bleeding with admission to the hospital during the study period. The standardized incidence rate ratio was 2.6 (95% confidence interval, 2.2-2.9), 2.3 in women and 2.8 in men. The standardized incidence rate ratio for combined use of low-dose aspirin and other nonsteroidal anti-inflammatory drugs was 5.6 (95% confidence interval, 4.4-7.0). The risk was similar among users of noncoated low-dose aspirin (standardized incidence rate ratio, 2.6; 95% confidence interval, 1.8-3.5) and coated low-dose aspirin (standardized incidence rate ratio, 2.6; 95% confidence interval, 2.2-3.0).\nCONCLUSIONS: Use of low-dose aspirin was associated with an increased risk of upper gastrointestinal bleeding, with still higher risks when combined with other nonsteroidal anti-inflammatory drugs. Enteric coating did not seem to reduce the risk. The findings from this observational study raise the possibility that prophylactic use of low-dose aspirin may convey an increased risk of gastrointestinal bleeding, which may offset some of its benefits.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/j.1572-0241.2000.02248.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019809", 
        "issn": [
          "0002-9270", 
          "1572-0241"
        ], 
        "name": "The American Journal of Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "95"
      }
    ], 
    "name": "Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin", 
    "pagination": "ajg2000570", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1038a2aa71c30e168a30b8213aa7e8ce47042fb24aa26b4039658c41b243d025"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11007221"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0421030"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1572-0241.2000.02248.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003405193"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1572-0241.2000.02248.x", 
      "https://app.dimensions.ai/details/publication/pub.1003405193"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ajg2000570"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02248.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02248.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02248.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02248.x'


 

This table displays all metadata directly associated to this object as RDF triples.

293 TRIPLES      21 PREDICATES      79 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1572-0241.2000.02248.x schema:about N00e3731b8b9740478da0e27969cca00b
2 N04c8fa00203d4e1e9d5699cf0fe5812f
3 N0b34f4a2c0854cb2a180699f00a24cc7
4 N18813a0a47c642059f38148f4fd65c27
5 N237efb29a31a4c1da754faf5fffab016
6 N402bc73369a647e5a5a3ffd05b761eda
7 N61befad584814a059edd51b2964bdb2e
8 N61da704abaa446d289531b66f55887d8
9 N65252c2ce9ca4e20b8afbfd8898f9a60
10 N69f8bf1451254ac090c472116a1b97af
11 N6a8f8230f44a40a487a9d5a8c7f87be6
12 N73ea447773c94943ad9daf4980c534ae
13 N8443d821a5ae4c8b8978e6f2052c763d
14 N9d5506dd7cd347a7a0f27842c6a33c5b
15 Naaba430dbf0d46caa0cc8176781d9729
16 Naae4cfad3eee46e19a2e372432f99372
17 Nbf66c229f4fd4de8af45b2a58691087f
18 Nc69f96e2ddf04eb5acfedebcd039330e
19 Nc6c55c763987438cb07624400cfcf73b
20 Nf28718067ff7456bb85e78d0a1125a9f
21 Nf77f12534b0f473db2dd017d2640e34c
22 anzsrc-for:11
23 anzsrc-for:1117
24 schema:author Nf353d99cf36e4528874000557c0c1071
25 schema:citation sg:pub.10.1023/a:1018832902287
26 sg:pub.10.1038/clpt.1993.55
27 https://app.dimensions.ai/details/publication/pub.1083187895
28 https://doi.org/10.1001/archinte.148.2.281
29 https://doi.org/10.1016/0140-6736(90)92336-g
30 https://doi.org/10.1016/0140-6736(91)92233-r
31 https://doi.org/10.1016/0895-4356(88)90007-8
32 https://doi.org/10.1016/s0140-6736(05)76185-7
33 https://doi.org/10.1016/s0140-6736(80)90282-2
34 https://doi.org/10.1016/s0140-6736(89)91200-2
35 https://doi.org/10.1016/s0140-6736(94)91843-0
36 https://doi.org/10.1016/s0140-6736(96)01254-8
37 https://doi.org/10.1016/s0140-6736(97)11475-1
38 https://doi.org/10.1016/s0140-6736(98)04311-6
39 https://doi.org/10.1016/s0895-4356(99)00004-9
40 https://doi.org/10.1055/s-0038-1656307
41 https://doi.org/10.1056/nejm198007173030305
42 https://doi.org/10.1111/j.1365-2036.1994.tb00271.x
43 https://doi.org/10.1111/j.1365-2125.1991.tb05616.x
44 https://doi.org/10.1111/j.1365-2125.1993.tb05689.x
45 https://doi.org/10.1111/j.1365-2796.1997.tb00023.x
46 https://doi.org/10.1136/bmj.296.6618.307
47 https://doi.org/10.1136/bmj.297.6659.1311
48 https://doi.org/10.1136/bmj.310.6983.827
49 https://doi.org/10.1136/bmj.311.6999.222
50 https://doi.org/10.1136/bmj.315.7107.510
51 https://doi.org/10.1136/bmj.315.7119.1333
52 https://doi.org/10.3233/jrs-1997-10101
53 https://doi.org/10.3233/jrs-1997-10309
54 schema:datePublished 2000-09
55 schema:datePublishedReg 2000-09-01
56 schema:description OBJECTIVE: Aspirin products are known to cause irritation and injury to the gastric mucosa. We examined the risk of hospitalization for upper gastrointestinal bleeding with use of low-dose aspirin. METHODS: This was a cohort study based on record linkage between a population-based prescription database and a hospital discharge registry in North Jutland County, Denmark, from January 1, 1991, to December 31, 1995. Incidence rates of upper gastrointestinal bleeding in 27,694 users of low-dose aspirin were compared with the incidence rates in the general population in the county. RESULTS: A total of 207 exclusive users of low-dose aspirin experienced a first episode of upper gastrointestinal bleeding with admission to the hospital during the study period. The standardized incidence rate ratio was 2.6 (95% confidence interval, 2.2-2.9), 2.3 in women and 2.8 in men. The standardized incidence rate ratio for combined use of low-dose aspirin and other nonsteroidal anti-inflammatory drugs was 5.6 (95% confidence interval, 4.4-7.0). The risk was similar among users of noncoated low-dose aspirin (standardized incidence rate ratio, 2.6; 95% confidence interval, 1.8-3.5) and coated low-dose aspirin (standardized incidence rate ratio, 2.6; 95% confidence interval, 2.2-3.0). CONCLUSIONS: Use of low-dose aspirin was associated with an increased risk of upper gastrointestinal bleeding, with still higher risks when combined with other nonsteroidal anti-inflammatory drugs. Enteric coating did not seem to reduce the risk. The findings from this observational study raise the possibility that prophylactic use of low-dose aspirin may convey an increased risk of gastrointestinal bleeding, which may offset some of its benefits.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N1e709f2562eb46d5a9a35d852d2e2ccb
61 N426a648a4af0407fbf30e52bc3f69ab1
62 sg:journal.1019809
63 schema:name Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin
64 schema:pagination ajg2000570
65 schema:productId N063e8deb039447fa893eea803f44a691
66 N98844f6709cc4e4e878d183c424684d8
67 Nbc4e50ac38994b12adeb416aa105f806
68 Nbf04288381674e0f92fbef76e248673c
69 Nfd09960b4bee49ed882e4aa0cda96b99
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003405193
71 https://doi.org/10.1111/j.1572-0241.2000.02248.x
72 schema:sdDatePublished 2019-04-10T15:00
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nb43c53dfd768422ab19d15a9e456c4c1
75 schema:url http://www.nature.com/articles/ajg2000570
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N00e3731b8b9740478da0e27969cca00b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Administration, Oral
81 rdf:type schema:DefinedTerm
82 N04c8fa00203d4e1e9d5699cf0fe5812f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Surveys and Questionnaires
84 rdf:type schema:DefinedTerm
85 N063e8deb039447fa893eea803f44a691 schema:name dimensions_id
86 schema:value pub.1003405193
87 rdf:type schema:PropertyValue
88 N0b34f4a2c0854cb2a180699f00a24cc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Adult
90 rdf:type schema:DefinedTerm
91 N18813a0a47c642059f38148f4fd65c27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Middle Aged
93 rdf:type schema:DefinedTerm
94 N1e709f2562eb46d5a9a35d852d2e2ccb schema:issueNumber 9
95 rdf:type schema:PublicationIssue
96 N237efb29a31a4c1da754faf5fffab016 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Male
98 rdf:type schema:DefinedTerm
99 N402bc73369a647e5a5a3ffd05b761eda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Female
101 rdf:type schema:DefinedTerm
102 N426a648a4af0407fbf30e52bc3f69ab1 schema:volumeNumber 95
103 rdf:type schema:PublicationVolume
104 N53c53b685c274ce1876a96b945a9c05a rdf:first sg:person.01030775563.24
105 rdf:rest N84f00a7851c641c3bafe75615a8bf34b
106 N61befad584814a059edd51b2964bdb2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Age Distribution
108 rdf:type schema:DefinedTerm
109 N61da704abaa446d289531b66f55887d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Aspirin
111 rdf:type schema:DefinedTerm
112 N65252c2ce9ca4e20b8afbfd8898f9a60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 N69f8bf1451254ac090c472116a1b97af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Nonprescription Drugs
117 rdf:type schema:DefinedTerm
118 N6a8f8230f44a40a487a9d5a8c7f87be6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Sex Distribution
120 rdf:type schema:DefinedTerm
121 N73ea447773c94943ad9daf4980c534ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Incidence
123 rdf:type schema:DefinedTerm
124 N7d8ac9f69f8d4780af401f9f9b708342 rdf:first sg:person.01224434067.19
125 rdf:rest Ne911a22e09204601ab3e4a255ba2917a
126 N8443d821a5ae4c8b8978e6f2052c763d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Retrospective Studies
128 rdf:type schema:DefinedTerm
129 N84f00a7851c641c3bafe75615a8bf34b rdf:first sg:person.0637111572.48
130 rdf:rest Nc095a83b1f9c4c2ea33d8764b7e9c882
131 N98844f6709cc4e4e878d183c424684d8 schema:name readcube_id
132 schema:value 1038a2aa71c30e168a30b8213aa7e8ce47042fb24aa26b4039658c41b243d025
133 rdf:type schema:PropertyValue
134 N9d5506dd7cd347a7a0f27842c6a33c5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Adolescent
136 rdf:type schema:DefinedTerm
137 Naaba430dbf0d46caa0cc8176781d9729 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Denmark
139 rdf:type schema:DefinedTerm
140 Naae4cfad3eee46e19a2e372432f99372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Confidence Intervals
142 rdf:type schema:DefinedTerm
143 Nb35d66ea79e849d08a164377d992f01d rdf:first sg:person.016011671300.14
144 rdf:rest rdf:nil
145 Nb43c53dfd768422ab19d15a9e456c4c1 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Nbc4e50ac38994b12adeb416aa105f806 schema:name nlm_unique_id
148 schema:value 0421030
149 rdf:type schema:PropertyValue
150 Nbf04288381674e0f92fbef76e248673c schema:name doi
151 schema:value 10.1111/j.1572-0241.2000.02248.x
152 rdf:type schema:PropertyValue
153 Nbf66c229f4fd4de8af45b2a58691087f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Aged
155 rdf:type schema:DefinedTerm
156 Nc095a83b1f9c4c2ea33d8764b7e9c882 rdf:first sg:person.012525351037.04
157 rdf:rest Nb35d66ea79e849d08a164377d992f01d
158 Nc69f96e2ddf04eb5acfedebcd039330e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Diagnosis, Differential
160 rdf:type schema:DefinedTerm
161 Nc6c55c763987438cb07624400cfcf73b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Gastrointestinal Hemorrhage
163 rdf:type schema:DefinedTerm
164 Ne911a22e09204601ab3e4a255ba2917a rdf:first sg:person.01236726331.40
165 rdf:rest N53c53b685c274ce1876a96b945a9c05a
166 Nf28718067ff7456bb85e78d0a1125a9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Anti-Inflammatory Agents, Non-Steroidal
168 rdf:type schema:DefinedTerm
169 Nf353d99cf36e4528874000557c0c1071 rdf:first sg:person.015362420175.18
170 rdf:rest N7d8ac9f69f8d4780af401f9f9b708342
171 Nf77f12534b0f473db2dd017d2640e34c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Cohort Studies
173 rdf:type schema:DefinedTerm
174 Nfd09960b4bee49ed882e4aa0cda96b99 schema:name pubmed_id
175 schema:value 11007221
176 rdf:type schema:PropertyValue
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
181 schema:name Public Health and Health Services
182 rdf:type schema:DefinedTerm
183 sg:journal.1019809 schema:issn 0002-9270
184 1572-0241
185 schema:name The American Journal of Gastroenterology
186 rdf:type schema:Periodical
187 sg:person.01030775563.24 schema:affiliation https://www.grid.ac/institutes/grid.27530.33
188 schema:familyName Nielsen
189 schema:givenName Gunnar Lauge
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030775563.24
191 rdf:type schema:Person
192 sg:person.01224434067.19 schema:affiliation https://www.grid.ac/institutes/grid.417390.8
193 schema:familyName Mellemkjær
194 schema:givenName Lene
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224434067.19
196 rdf:type schema:Person
197 sg:person.01236726331.40 schema:affiliation https://www.grid.ac/institutes/grid.419344.f
198 schema:familyName Blot
199 schema:givenName William J
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236726331.40
201 rdf:type schema:Person
202 sg:person.012525351037.04 schema:affiliation https://www.grid.ac/institutes/grid.419344.f
203 schema:familyName McLaughlin
204 schema:givenName Joseph K
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525351037.04
206 rdf:type schema:Person
207 sg:person.015362420175.18 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
208 schema:familyName Sørensen
209 schema:givenName Henrik Toft
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015362420175.18
211 rdf:type schema:Person
212 sg:person.016011671300.14 schema:affiliation https://www.grid.ac/institutes/grid.417390.8
213 schema:familyName Olsen
214 schema:givenName Jørgen H
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016011671300.14
216 rdf:type schema:Person
217 sg:person.0637111572.48 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
218 schema:familyName Steffensen
219 schema:givenName Flemming Hald
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637111572.48
221 rdf:type schema:Person
222 sg:pub.10.1023/a:1018832902287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009378226
223 https://doi.org/10.1023/a:1018832902287
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/clpt.1993.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023293498
226 https://doi.org/10.1038/clpt.1993.55
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1083187895 schema:CreativeWork
229 https://doi.org/10.1001/archinte.148.2.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054111924
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0140-6736(90)92336-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1049813580
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0140-6736(91)92233-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1008744960
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0895-4356(88)90007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001575625
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0140-6736(05)76185-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016667682
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0140-6736(80)90282-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046507171
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0140-6736(89)91200-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052649741
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0140-6736(94)91843-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046185961
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0140-6736(96)01254-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027052083
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0140-6736(97)11475-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000802716
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0140-6736(98)04311-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008729184
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0895-4356(99)00004-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032838571
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1055/s-0038-1656307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076838836
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1056/nejm198007173030305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038980827
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1365-2036.1994.tb00271.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036068723
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1365-2125.1991.tb05616.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046712815
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1365-2125.1993.tb05689.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019997851
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1365-2796.1997.tb00023.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046089208
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1136/bmj.296.6618.307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003351315
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1136/bmj.297.6659.1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017641277
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1136/bmj.310.6983.827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062771415
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1136/bmj.311.6999.222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062772688
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1136/bmj.315.7107.510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062780601
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1136/bmj.315.7119.1333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062781362
276 rdf:type schema:CreativeWork
277 https://doi.org/10.3233/jrs-1997-10101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078705511
278 rdf:type schema:CreativeWork
279 https://doi.org/10.3233/jrs-1997-10309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078705562
280 rdf:type schema:CreativeWork
281 https://www.grid.ac/institutes/grid.27530.33 schema:alternateName Aalborg Hospital
282 schema:name The Department of Medicine M, Aalborg Hospital, Aalborg, Denmark
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.417390.8 schema:alternateName Danish Cancer Society
285 schema:name The Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.419344.f schema:alternateName International Epidemiology Institute
288 schema:name The International Epidemiology Institute, Rockville, Maryland, USA
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
291 schema:name Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark
292 Department of Clinical Epidemiology, Aarhus University and Aalborg Hospitals, Aarhus, Denmark
293 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...