Methotrexate in Crohn's disease: long-term efficacy and toxicity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-07

AUTHORS

Marc Lémann, Taoufik Zenjari, Yoram Bouhnik, Jacques Cosnes, Bruno Mesnard, Jean-Claude Rambaud, Robert Modigliani, Antoine Cortot, Jean-Frédéric Colombel

ABSTRACT

OBJECTIVE: A 16-wk, placebo-controlled trial has recently shown weekly low-dose methotrexate to be an effective treatment for patients with chronically active Crohn's disease. The long-term efficacy and safety of this antimetabolite drug, however, are not yet well established and are assessed in this study. METHODS: A total of 49 patients with Crohn's disease who were treated with methotrexate for > or =6 months were studied. All patients had been chronically treated with steroids; but at the time of initiation, only 27 were still on steroids. Of the 49 patients, 42 had previously taken azathioprine but were no longer on this drug because of intolerance or failure. Clinical remission was defined as a Harvey-Bradshaw index of <4. RESULTS: In all, 41 patients achieved complete clinical remission and were maintained on methotrexate for a median of 18 months (range, 7-59 months). In these patients the probabilities of relapse were 29%, 41%, and 48% at 1, 2, and 3 yr, respectively. A higher rate of relapse was observed in women and in patients with ileocolitis. Adverse reactions were recorded in 24 patients, requiring discontinuation of methotrexate in five. A liver biopsy was performed in 11 patients; a mild steatosis was found in five, a slight dilation of the sinusoids in one, a granulomatous hepatitis with a mild portal fibrosis in one, and a slight periportal fibrosis in one patient. CONCLUSIONS: This study suggests a long-term benefit of maintenance treatment with methotrexate in patients with chronically active Crohn's disease, with side effects that are usually only moderate. More... »

PAGES

ajg2000446

References to SciGraph publications

  • 1993-10. Low-dose oral methotrexate in refractory inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x

    DOI

    http://dx.doi.org/10.1111/j.1572-0241.2000.02190.x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043635789

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10925976


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crohn Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunosuppressive Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Methotrexate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Saint-Louis", 
              "id": "https://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Saint-Louis, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00e9mann", 
            "givenName": "Marc", 
            "id": "sg:person.01115120151.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115120151.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Claude Huriez", 
              "id": "https://www.grid.ac/institutes/grid.413875.c", 
              "name": [
                "Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zenjari", 
            "givenName": "Taoufik", 
            "id": "sg:person.01251304412.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251304412.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Saint Lazare", 
              "id": "https://www.grid.ac/institutes/grid.414368.c", 
              "name": [
                "Service d'H\u00e9pato-Gastroenterologie, H\u00f4pital Saint-Lazare, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bouhnik", 
            "givenName": "Yoram", 
            "id": "sg:person.01317241031.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317241031.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Rothschild", 
              "id": "https://www.grid.ac/institutes/grid.414318.b", 
              "name": [
                "Service d'H\u00e9pato-Gastroenterologie, H\u00f4pital Rothschild, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cosnes", 
            "givenName": "Jacques", 
            "id": "sg:person.0721101162.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721101162.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Claude Huriez", 
              "id": "https://www.grid.ac/institutes/grid.413875.c", 
              "name": [
                "Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mesnard", 
            "givenName": "Bruno", 
            "id": "sg:person.0774361547.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774361547.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Saint Lazare", 
              "id": "https://www.grid.ac/institutes/grid.414368.c", 
              "name": [
                "Service d'H\u00e9pato-Gastroenterologie, H\u00f4pital Saint-Lazare, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rambaud", 
            "givenName": "Jean-Claude", 
            "id": "sg:person.011206427424.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206427424.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Saint-Louis", 
              "id": "https://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Saint-Louis, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Modigliani", 
            "givenName": "Robert", 
            "id": "sg:person.01341640552.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341640552.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Claude Huriez", 
              "id": "https://www.grid.ac/institutes/grid.413875.c", 
              "name": [
                "Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cortot", 
            "givenName": "Antoine", 
            "id": "sg:person.01351530045.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351530045.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Claude Huriez", 
              "id": "https://www.grid.ac/institutes/grid.413875.c", 
              "name": [
                "Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Colombel", 
            "givenName": "Jean-Fr\u00e9d\u00e9ric", 
            "id": "sg:person.0757213140.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757213140.40"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1056/nejm199502023320503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002011461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0953-0673.1996.00309.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014034579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199609193351215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015563977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(91)70025-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022206478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0190-9622(88)80237-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034663722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(96)90402-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034958446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(71)91123-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035485940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(71)91123-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035485940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780370304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036465747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(91)90790-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036967287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(80)92767-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040231074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4065/71.1.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045053077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(91)90457-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046317954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198005013021801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047671046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01296109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048230661", 
              "https://doi.org/10.1007/bf01296109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01296109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048230661", 
              "https://doi.org/10.1007/bf01296109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-110-5-353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073693791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077847199", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-07", 
        "datePublishedReg": "2000-07-01", 
        "description": "OBJECTIVE: A 16-wk, placebo-controlled trial has recently shown weekly low-dose methotrexate to be an effective treatment for patients with chronically active Crohn's disease. The long-term efficacy and safety of this antimetabolite drug, however, are not yet well established and are assessed in this study.\nMETHODS: A total of 49 patients with Crohn's disease who were treated with methotrexate for > or =6 months were studied. All patients had been chronically treated with steroids; but at the time of initiation, only 27 were still on steroids. Of the 49 patients, 42 had previously taken azathioprine but were no longer on this drug because of intolerance or failure. Clinical remission was defined as a Harvey-Bradshaw index of <4.\nRESULTS: In all, 41 patients achieved complete clinical remission and were maintained on methotrexate for a median of 18 months (range, 7-59 months). In these patients the probabilities of relapse were 29%, 41%, and 48% at 1, 2, and 3 yr, respectively. A higher rate of relapse was observed in women and in patients with ileocolitis. Adverse reactions were recorded in 24 patients, requiring discontinuation of methotrexate in five. A liver biopsy was performed in 11 patients; a mild steatosis was found in five, a slight dilation of the sinusoids in one, a granulomatous hepatitis with a mild portal fibrosis in one, and a slight periportal fibrosis in one patient.\nCONCLUSIONS: This study suggests a long-term benefit of maintenance treatment with methotrexate in patients with chronically active Crohn's disease, with side effects that are usually only moderate.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1111/j.1572-0241.2000.02190.x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1019809", 
            "issn": [
              "0002-9270", 
              "1572-0241"
            ], 
            "name": "The American Journal of Gastroenterology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "95"
          }
        ], 
        "name": "Methotrexate in Crohn's disease: long-term efficacy and toxicity", 
        "pagination": "ajg2000446", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "cfda63deef7d3c2448da4fb80c8bc14b36bee0c12d7c4774ce653d89e2069818"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "10925976"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0421030"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1111/j.1572-0241.2000.02190.x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1043635789"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1111/j.1572-0241.2000.02190.x", 
          "https://app.dimensions.ai/details/publication/pub.1043635789"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000433.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ajg2000446"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    230 TRIPLES      21 PREDICATES      57 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1111/j.1572-0241.2000.02190.x schema:about N0c8deeb252794e21b5892bd74515b66a
    2 N0ecaab5f71374bc68abb67aeaf8fe6fe
    3 N0f43994a01d446fd8780f10c0a7bc567
    4 N27dc3c1214eb403598a76bc1501d1a45
    5 N2d6d3bfe98524eea8c38ac23e82ef024
    6 N435ddc9aa13b4a9d9161829b06766220
    7 N6bd5f742e0b84612abc38ca806b6f37b
    8 N773fbe2c2fa249e4b036911b419b17f8
    9 Nbad0611e9d1343a4bfdcf0823aa237e0
    10 Ne1a44b187914463285b44a256d7e91e2
    11 Nf742140d34a64a02821611b2a2f82a2b
    12 Nfa8ff53544374efa9ece1712316d0e4b
    13 anzsrc-for:11
    14 anzsrc-for:1103
    15 schema:author Nc49fe001425b4fcb9a30b503e10637a6
    16 schema:citation sg:pub.10.1007/bf01296109
    17 https://app.dimensions.ai/details/publication/pub.1077847199
    18 https://doi.org/10.1002/art.1780370304
    19 https://doi.org/10.1016/0016-5085(91)70025-s
    20 https://doi.org/10.1016/0016-5085(91)90457-v
    21 https://doi.org/10.1016/0016-5085(91)90790-r
    22 https://doi.org/10.1016/s0140-6736(71)91123-8
    23 https://doi.org/10.1016/s0140-6736(80)92767-1
    24 https://doi.org/10.1016/s0140-6736(96)90402-x
    25 https://doi.org/10.1016/s0190-9622(88)80237-8
    26 https://doi.org/10.1056/nejm198005013021801
    27 https://doi.org/10.1056/nejm199502023320503
    28 https://doi.org/10.1056/nejm199609193351215
    29 https://doi.org/10.1111/j.0953-0673.1996.00309.x
    30 https://doi.org/10.4065/71.1.69
    31 https://doi.org/10.7326/0003-4819-110-5-353
    32 schema:datePublished 2000-07
    33 schema:datePublishedReg 2000-07-01
    34 schema:description OBJECTIVE: A 16-wk, placebo-controlled trial has recently shown weekly low-dose methotrexate to be an effective treatment for patients with chronically active Crohn's disease. The long-term efficacy and safety of this antimetabolite drug, however, are not yet well established and are assessed in this study. METHODS: A total of 49 patients with Crohn's disease who were treated with methotrexate for > or =6 months were studied. All patients had been chronically treated with steroids; but at the time of initiation, only 27 were still on steroids. Of the 49 patients, 42 had previously taken azathioprine but were no longer on this drug because of intolerance or failure. Clinical remission was defined as a Harvey-Bradshaw index of <4. RESULTS: In all, 41 patients achieved complete clinical remission and were maintained on methotrexate for a median of 18 months (range, 7-59 months). In these patients the probabilities of relapse were 29%, 41%, and 48% at 1, 2, and 3 yr, respectively. A higher rate of relapse was observed in women and in patients with ileocolitis. Adverse reactions were recorded in 24 patients, requiring discontinuation of methotrexate in five. A liver biopsy was performed in 11 patients; a mild steatosis was found in five, a slight dilation of the sinusoids in one, a granulomatous hepatitis with a mild portal fibrosis in one, and a slight periportal fibrosis in one patient. CONCLUSIONS: This study suggests a long-term benefit of maintenance treatment with methotrexate in patients with chronically active Crohn's disease, with side effects that are usually only moderate.
    35 schema:genre research_article
    36 schema:inLanguage en
    37 schema:isAccessibleForFree false
    38 schema:isPartOf N9c9f1643e4044e82972992dae0919800
    39 Nc0c347eaea474e178ae5eac865e74820
    40 sg:journal.1019809
    41 schema:name Methotrexate in Crohn's disease: long-term efficacy and toxicity
    42 schema:pagination ajg2000446
    43 schema:productId N4b50825a85f7472bb7fb47fadee7d94e
    44 Nb4e706a7a4214e88933768e11377212f
    45 Nbb6509a1265d4645b91d392f47df2fb4
    46 Nce4ac73a3306425aa6746149117ce38b
    47 Nfb8bbf79410f4d98b0bcb1703d8b25e6
    48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043635789
    49 https://doi.org/10.1111/j.1572-0241.2000.02190.x
    50 schema:sdDatePublished 2019-04-10T21:25
    51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    52 schema:sdPublisher N37dbe99ae9c44f64bb830653031afb62
    53 schema:url http://www.nature.com/articles/ajg2000446
    54 sgo:license sg:explorer/license/
    55 sgo:sdDataset articles
    56 rdf:type schema:ScholarlyArticle
    57 N0c8deeb252794e21b5892bd74515b66a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    58 schema:name Adolescent
    59 rdf:type schema:DefinedTerm
    60 N0d083ad24a8448448de29bb649ddc4c2 rdf:first sg:person.01251304412.36
    61 rdf:rest N97de397771684b839702855bd96aba58
    62 N0ecaab5f71374bc68abb67aeaf8fe6fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    63 schema:name Remission Induction
    64 rdf:type schema:DefinedTerm
    65 N0f43994a01d446fd8780f10c0a7bc567 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    66 schema:name Follow-Up Studies
    67 rdf:type schema:DefinedTerm
    68 N27dc3c1214eb403598a76bc1501d1a45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    69 schema:name Immunosuppressive Agents
    70 rdf:type schema:DefinedTerm
    71 N2d6d3bfe98524eea8c38ac23e82ef024 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    72 schema:name Female
    73 rdf:type schema:DefinedTerm
    74 N37dbe99ae9c44f64bb830653031afb62 schema:name Springer Nature - SN SciGraph project
    75 rdf:type schema:Organization
    76 N435ddc9aa13b4a9d9161829b06766220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Humans
    78 rdf:type schema:DefinedTerm
    79 N4b50825a85f7472bb7fb47fadee7d94e schema:name pubmed_id
    80 schema:value 10925976
    81 rdf:type schema:PropertyValue
    82 N52aba42f0cef4e95938102ca35bfb36c rdf:first sg:person.0757213140.40
    83 rdf:rest rdf:nil
    84 N5db9ec9dc08a4549915fc7ec27e67a17 rdf:first sg:person.0774361547.44
    85 rdf:rest Nce1a5c235e1844a092c8d2656e09570e
    86 N6bd5f742e0b84612abc38ca806b6f37b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Middle Aged
    88 rdf:type schema:DefinedTerm
    89 N773fbe2c2fa249e4b036911b419b17f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Time Factors
    91 rdf:type schema:DefinedTerm
    92 N869f0e51ca5c4b69aee4e55c14220b90 rdf:first sg:person.01341640552.26
    93 rdf:rest N8b81d91e019f4bc3b8aadc51fa44e4e7
    94 N8b81d91e019f4bc3b8aadc51fa44e4e7 rdf:first sg:person.01351530045.67
    95 rdf:rest N52aba42f0cef4e95938102ca35bfb36c
    96 N97de397771684b839702855bd96aba58 rdf:first sg:person.01317241031.05
    97 rdf:rest Nfb9ce36f2d1e4c929739070376d86f93
    98 N9c9f1643e4044e82972992dae0919800 schema:issueNumber 7
    99 rdf:type schema:PublicationIssue
    100 Nb4e706a7a4214e88933768e11377212f schema:name nlm_unique_id
    101 schema:value 0421030
    102 rdf:type schema:PropertyValue
    103 Nbad0611e9d1343a4bfdcf0823aa237e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Adult
    105 rdf:type schema:DefinedTerm
    106 Nbb6509a1265d4645b91d392f47df2fb4 schema:name dimensions_id
    107 schema:value pub.1043635789
    108 rdf:type schema:PropertyValue
    109 Nc0c347eaea474e178ae5eac865e74820 schema:volumeNumber 95
    110 rdf:type schema:PublicationVolume
    111 Nc49fe001425b4fcb9a30b503e10637a6 rdf:first sg:person.01115120151.97
    112 rdf:rest N0d083ad24a8448448de29bb649ddc4c2
    113 Nce1a5c235e1844a092c8d2656e09570e rdf:first sg:person.011206427424.51
    114 rdf:rest N869f0e51ca5c4b69aee4e55c14220b90
    115 Nce4ac73a3306425aa6746149117ce38b schema:name doi
    116 schema:value 10.1111/j.1572-0241.2000.02190.x
    117 rdf:type schema:PropertyValue
    118 Ne1a44b187914463285b44a256d7e91e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Crohn Disease
    120 rdf:type schema:DefinedTerm
    121 Nf742140d34a64a02821611b2a2f82a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Male
    123 rdf:type schema:DefinedTerm
    124 Nfa8ff53544374efa9ece1712316d0e4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Methotrexate
    126 rdf:type schema:DefinedTerm
    127 Nfb8bbf79410f4d98b0bcb1703d8b25e6 schema:name readcube_id
    128 schema:value cfda63deef7d3c2448da4fb80c8bc14b36bee0c12d7c4774ce653d89e2069818
    129 rdf:type schema:PropertyValue
    130 Nfb9ce36f2d1e4c929739070376d86f93 rdf:first sg:person.0721101162.58
    131 rdf:rest N5db9ec9dc08a4549915fc7ec27e67a17
    132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    133 schema:name Medical and Health Sciences
    134 rdf:type schema:DefinedTerm
    135 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Clinical Sciences
    137 rdf:type schema:DefinedTerm
    138 sg:journal.1019809 schema:issn 0002-9270
    139 1572-0241
    140 schema:name The American Journal of Gastroenterology
    141 rdf:type schema:Periodical
    142 sg:person.01115120151.97 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
    143 schema:familyName Lémann
    144 schema:givenName Marc
    145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115120151.97
    146 rdf:type schema:Person
    147 sg:person.011206427424.51 schema:affiliation https://www.grid.ac/institutes/grid.414368.c
    148 schema:familyName Rambaud
    149 schema:givenName Jean-Claude
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206427424.51
    151 rdf:type schema:Person
    152 sg:person.01251304412.36 schema:affiliation https://www.grid.ac/institutes/grid.413875.c
    153 schema:familyName Zenjari
    154 schema:givenName Taoufik
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251304412.36
    156 rdf:type schema:Person
    157 sg:person.01317241031.05 schema:affiliation https://www.grid.ac/institutes/grid.414368.c
    158 schema:familyName Bouhnik
    159 schema:givenName Yoram
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317241031.05
    161 rdf:type schema:Person
    162 sg:person.01341640552.26 schema:affiliation https://www.grid.ac/institutes/grid.413328.f
    163 schema:familyName Modigliani
    164 schema:givenName Robert
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341640552.26
    166 rdf:type schema:Person
    167 sg:person.01351530045.67 schema:affiliation https://www.grid.ac/institutes/grid.413875.c
    168 schema:familyName Cortot
    169 schema:givenName Antoine
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351530045.67
    171 rdf:type schema:Person
    172 sg:person.0721101162.58 schema:affiliation https://www.grid.ac/institutes/grid.414318.b
    173 schema:familyName Cosnes
    174 schema:givenName Jacques
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721101162.58
    176 rdf:type schema:Person
    177 sg:person.0757213140.40 schema:affiliation https://www.grid.ac/institutes/grid.413875.c
    178 schema:familyName Colombel
    179 schema:givenName Jean-Frédéric
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757213140.40
    181 rdf:type schema:Person
    182 sg:person.0774361547.44 schema:affiliation https://www.grid.ac/institutes/grid.413875.c
    183 schema:familyName Mesnard
    184 schema:givenName Bruno
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774361547.44
    186 rdf:type schema:Person
    187 sg:pub.10.1007/bf01296109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048230661
    188 https://doi.org/10.1007/bf01296109
    189 rdf:type schema:CreativeWork
    190 https://app.dimensions.ai/details/publication/pub.1077847199 schema:CreativeWork
    191 https://doi.org/10.1002/art.1780370304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036465747
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/0016-5085(91)70025-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1022206478
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/0016-5085(91)90457-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1046317954
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/0016-5085(91)90790-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1036967287
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/s0140-6736(71)91123-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035485940
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/s0140-6736(80)92767-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040231074
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/s0140-6736(96)90402-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034958446
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/s0190-9622(88)80237-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034663722
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1056/nejm198005013021801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047671046
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1056/nejm199502023320503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002011461
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1056/nejm199609193351215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015563977
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1111/j.0953-0673.1996.00309.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014034579
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.4065/71.1.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045053077
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.7326/0003-4819-110-5-353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073693791
    218 rdf:type schema:CreativeWork
    219 https://www.grid.ac/institutes/grid.413328.f schema:alternateName Hôpital Saint-Louis
    220 schema:name Service d'Hépato-Gastroentérologie, Hôpital Saint-Louis, Paris, France
    221 rdf:type schema:Organization
    222 https://www.grid.ac/institutes/grid.413875.c schema:alternateName Hôpital Claude Huriez
    223 schema:name Service d'Hépato-Gastroentérologie, Hôpital Huriez, Centre Hospitalier Régional et Universitaire, Lille, France
    224 rdf:type schema:Organization
    225 https://www.grid.ac/institutes/grid.414318.b schema:alternateName Hôpital Rothschild
    226 schema:name Service d'Hépato-Gastroenterologie, Hôpital Rothschild, Paris, France
    227 rdf:type schema:Organization
    228 https://www.grid.ac/institutes/grid.414368.c schema:alternateName Hôpital Saint Lazare
    229 schema:name Service d'Hépato-Gastroenterologie, Hôpital Saint-Lazare, Paris, France
    230 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...