Ontology type: schema:ScholarlyArticle
2000-07
AUTHORSMarc Lémann, Taoufik Zenjari, Yoram Bouhnik, Jacques Cosnes, Bruno Mesnard, Jean-Claude Rambaud, Robert Modigliani, Antoine Cortot, Jean-Frédéric Colombel
ABSTRACTOBJECTIVE: A 16-wk, placebo-controlled trial has recently shown weekly low-dose methotrexate to be an effective treatment for patients with chronically active Crohn's disease. The long-term efficacy and safety of this antimetabolite drug, however, are not yet well established and are assessed in this study. METHODS: A total of 49 patients with Crohn's disease who were treated with methotrexate for > or =6 months were studied. All patients had been chronically treated with steroids; but at the time of initiation, only 27 were still on steroids. Of the 49 patients, 42 had previously taken azathioprine but were no longer on this drug because of intolerance or failure. Clinical remission was defined as a Harvey-Bradshaw index of <4. RESULTS: In all, 41 patients achieved complete clinical remission and were maintained on methotrexate for a median of 18 months (range, 7-59 months). In these patients the probabilities of relapse were 29%, 41%, and 48% at 1, 2, and 3 yr, respectively. A higher rate of relapse was observed in women and in patients with ileocolitis. Adverse reactions were recorded in 24 patients, requiring discontinuation of methotrexate in five. A liver biopsy was performed in 11 patients; a mild steatosis was found in five, a slight dilation of the sinusoids in one, a granulomatous hepatitis with a mild portal fibrosis in one, and a slight periportal fibrosis in one patient. CONCLUSIONS: This study suggests a long-term benefit of maintenance treatment with methotrexate in patients with chronically active Crohn's disease, with side effects that are usually only moderate. More... »
PAGESajg2000446
http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x
DOIhttp://dx.doi.org/10.1111/j.1572-0241.2000.02190.x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1043635789
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10925976
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crohn Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunosuppressive Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methotrexate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Remission Induction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Time Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "H\u00f4pital Saint-Louis",
"id": "https://www.grid.ac/institutes/grid.413328.f",
"name": [
"Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Saint-Louis, Paris, France"
],
"type": "Organization"
},
"familyName": "L\u00e9mann",
"givenName": "Marc",
"id": "sg:person.01115120151.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115120151.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Claude Huriez",
"id": "https://www.grid.ac/institutes/grid.413875.c",
"name": [
"Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
],
"type": "Organization"
},
"familyName": "Zenjari",
"givenName": "Taoufik",
"id": "sg:person.01251304412.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251304412.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint Lazare",
"id": "https://www.grid.ac/institutes/grid.414368.c",
"name": [
"Service d'H\u00e9pato-Gastroenterologie, H\u00f4pital Saint-Lazare, Paris, France"
],
"type": "Organization"
},
"familyName": "Bouhnik",
"givenName": "Yoram",
"id": "sg:person.01317241031.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317241031.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Rothschild",
"id": "https://www.grid.ac/institutes/grid.414318.b",
"name": [
"Service d'H\u00e9pato-Gastroenterologie, H\u00f4pital Rothschild, Paris, France"
],
"type": "Organization"
},
"familyName": "Cosnes",
"givenName": "Jacques",
"id": "sg:person.0721101162.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721101162.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Claude Huriez",
"id": "https://www.grid.ac/institutes/grid.413875.c",
"name": [
"Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
],
"type": "Organization"
},
"familyName": "Mesnard",
"givenName": "Bruno",
"id": "sg:person.0774361547.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774361547.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint Lazare",
"id": "https://www.grid.ac/institutes/grid.414368.c",
"name": [
"Service d'H\u00e9pato-Gastroenterologie, H\u00f4pital Saint-Lazare, Paris, France"
],
"type": "Organization"
},
"familyName": "Rambaud",
"givenName": "Jean-Claude",
"id": "sg:person.011206427424.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206427424.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint-Louis",
"id": "https://www.grid.ac/institutes/grid.413328.f",
"name": [
"Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Saint-Louis, Paris, France"
],
"type": "Organization"
},
"familyName": "Modigliani",
"givenName": "Robert",
"id": "sg:person.01341640552.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341640552.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Claude Huriez",
"id": "https://www.grid.ac/institutes/grid.413875.c",
"name": [
"Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
],
"type": "Organization"
},
"familyName": "Cortot",
"givenName": "Antoine",
"id": "sg:person.01351530045.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351530045.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Claude Huriez",
"id": "https://www.grid.ac/institutes/grid.413875.c",
"name": [
"Service d'H\u00e9pato-Gastroent\u00e9rologie, H\u00f4pital Huriez, Centre Hospitalier R\u00e9gional et Universitaire, Lille, France"
],
"type": "Organization"
},
"familyName": "Colombel",
"givenName": "Jean-Fr\u00e9d\u00e9ric",
"id": "sg:person.0757213140.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757213140.40"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1056/nejm199502023320503",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002011461"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.0953-0673.1996.00309.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014034579"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199609193351215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015563977"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0016-5085(91)70025-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022206478"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0190-9622(88)80237-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034663722"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(96)90402-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034958446"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(71)91123-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035485940"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(71)91123-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035485940"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.1780370304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036465747"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0016-5085(91)90790-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036967287"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(80)92767-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040231074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4065/71.1.69",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045053077"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0016-5085(91)90457-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046317954"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm198005013021801",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047671046"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01296109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048230661",
"https://doi.org/10.1007/bf01296109"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01296109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048230661",
"https://doi.org/10.1007/bf01296109"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-110-5-353",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073693791"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077847199",
"type": "CreativeWork"
}
],
"datePublished": "2000-07",
"datePublishedReg": "2000-07-01",
"description": "OBJECTIVE: A 16-wk, placebo-controlled trial has recently shown weekly low-dose methotrexate to be an effective treatment for patients with chronically active Crohn's disease. The long-term efficacy and safety of this antimetabolite drug, however, are not yet well established and are assessed in this study.\nMETHODS: A total of 49 patients with Crohn's disease who were treated with methotrexate for > or =6 months were studied. All patients had been chronically treated with steroids; but at the time of initiation, only 27 were still on steroids. Of the 49 patients, 42 had previously taken azathioprine but were no longer on this drug because of intolerance or failure. Clinical remission was defined as a Harvey-Bradshaw index of <4.\nRESULTS: In all, 41 patients achieved complete clinical remission and were maintained on methotrexate for a median of 18 months (range, 7-59 months). In these patients the probabilities of relapse were 29%, 41%, and 48% at 1, 2, and 3 yr, respectively. A higher rate of relapse was observed in women and in patients with ileocolitis. Adverse reactions were recorded in 24 patients, requiring discontinuation of methotrexate in five. A liver biopsy was performed in 11 patients; a mild steatosis was found in five, a slight dilation of the sinusoids in one, a granulomatous hepatitis with a mild portal fibrosis in one, and a slight periportal fibrosis in one patient.\nCONCLUSIONS: This study suggests a long-term benefit of maintenance treatment with methotrexate in patients with chronically active Crohn's disease, with side effects that are usually only moderate.",
"genre": "research_article",
"id": "sg:pub.10.1111/j.1572-0241.2000.02190.x",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1019809",
"issn": [
"0002-9270",
"1572-0241"
],
"name": "The American Journal of Gastroenterology",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "95"
}
],
"name": "Methotrexate in Crohn's disease: long-term efficacy and toxicity",
"pagination": "ajg2000446",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"cfda63deef7d3c2448da4fb80c8bc14b36bee0c12d7c4774ce653d89e2069818"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"10925976"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0421030"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1111/j.1572-0241.2000.02190.x"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1043635789"
]
}
],
"sameAs": [
"https://doi.org/10.1111/j.1572-0241.2000.02190.x",
"https://app.dimensions.ai/details/publication/pub.1043635789"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T21:25",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000433.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/ajg2000446"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.02190.x'
This table displays all metadata directly associated to this object as RDF triples.
230 TRIPLES
21 PREDICATES
57 URIs
33 LITERALS
21 BLANK NODES