Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-α and 5-fluorouracil View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-01-01

AUTHORS

Christophe Cellier, César Yaghi, Emmanuel Cuillerier, Nathalie Siauve, Anne Berger, Françoise Carnot, Charles Haddad, Jean Philippe Barbier, Bruno Landi

ABSTRACT

The VIPoma syndrome is rare. It is usually caused by a neuroendocrine tumor located in the pancreas. Somatostatin analogs and interferon-a can be helpful in the symptomatic control of the disease, but the efficacy of chemotherapy in metastatic disease is limited. We report the case of a 32-yr-old patient who had a primary intestinal VIPoma with peritoneal carcinomatosis and hepatic metastases. Somatostatin analogs and conventional chemotherapy regimens were not effective on VIPoma syndrome and tumor progression. The combination of 5- fluorouracil and interferon-alpha was associated with a major clinical improvement and tumor regression. Further investigations should evaluate the place of such a combination as a first line treatment for patients with metastatic neuroendocrine tumors. More... »

PAGES

289

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.2000.01711.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.2000.01711.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039161653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10638600


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