Specialized columnar epithelium of the esophagogastric junction: prevalence and associations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-04

AUTHORS

Ilkka Kunnamo, Jukka-Pekka Mecklin, Kari Mauranen, Kyösti Nuorva, Markku Voutilainen, Martti Färkkilä, Matti Juhola, Pentti Sipponen, Timo Mäntynen

ABSTRACT

OBJECTIVES: In Barrett's esophagus (BE) normal squamous esophageal epithelium is replaced by specialized columnar epithelium (SCE). BE is related to gastroesophageal reflux disease (GERD) and is a risk factor for esophageal adenocarcinoma. SCE is detected also at normal-appearing esophagogastric junction without BE (junctional SCE). The relationships between junctional SCE, GERD, and cardia adenocarcinoma are obscure and controversial. The aims of the present study were to investigate the prevalence and demographics of junctional SCE and to compare these figures with those reported for BE, and esophageal and cardia adenocarcinoma. A further aim was to examine the association between junctional SCE and GERD, Helicobacter pylori infection, and gastritis. METHODS: One thousand one hundred-nineteen consecutive dyspeptic patients underwent gastroscopy and were enrolled into the study. RESULTS: Junctional SCE was detected in 110 patients (10%). The age-specific prevalence of junctional SCE increased with age. The male:female ratio was 1:1.1. In multivariate analysis, junctional SCE was independently and positively related to endoscopic erosive esophagitis (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-3.1), cardia inflammation (carditis) (OR, 3.1; 95% CI, 1.4-6.8), and age (OR, 1.4 per decade; 95% CI, 1.2-1.6), but not to corpus H. pylori infection (OR, 1.4; 95% CI, 0.7-2.8), antral (OR, 1.0; 95% CI, 0.5-2.1) or corpus (OR, 0.8; 95% CI, 0.4-1.8) gastritis, or intestinal metaplasia of the antral mucosa in stomach (OR, 1.2; 95% CI, 0.7-2.1). In univariate analysis, junctional SCE was, however, significantly more common in patients with antral-predominant atrophic gastritis (20%), compared with those with normal gastric histology (8%, p < 0.001). CONCLUSIONS: Junctional SCE is age related and may therefore be an acquired lesion. It is associated with cardia inflammation and endoscopic erosive esophagitis, but not with H. pylori infection or gastric intestinal metaplasia. Unlike BE and cardia cancer, junctional SCE occurs with similar frequency in men and women. More... »

PAGES

913

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.986_i.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.1999.986_i.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047572521

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10201456


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Barrett Esophagus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Esophagogastric Junction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Finland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastroesophageal Reflux", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter pylori", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Karstula Health Centre, Karstula, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kunnamo", 
        "givenName": "Ilkka", 
        "id": "sg:person.01010044564.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010044564.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Finland Health Care District", 
          "id": "https://www.grid.ac/institutes/grid.460356.2", 
          "name": [
            "Department ofSurgery, Jyv\u00e4skyl\u00e4 Central Hospital, Jyv\u00e4skyl\u00e4, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mecklin", 
        "givenName": "Jukka-Pekka", 
        "id": "sg:person.0753761213.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753761213.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Finland", 
          "id": "https://www.grid.ac/institutes/grid.9668.1", 
          "name": [
            "Department of Health Policy and Management, Kuopio University, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mauranen", 
        "givenName": "Kari", 
        "id": "sg:person.0613721554.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613721554.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Finland Health Care District", 
          "id": "https://www.grid.ac/institutes/grid.460356.2", 
          "name": [
            "Department ofPathology, Jyv\u00e4skyl\u00e4 Central Hospital, Jyv\u00e4skyl\u00e4, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuorva", 
        "givenName": "Ky\u00f6sti", 
        "id": "sg:person.01151670313.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151670313.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Finland Health Care District", 
          "id": "https://www.grid.ac/institutes/grid.460356.2", 
          "name": [
            "Department of Internal Medicine Jyv\u00e4skyl\u00e4 Central Hospital, Jyv\u00e4skyl\u00e4, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voutilainen", 
        "givenName": "Markku", 
        "id": "sg:person.0612075760.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612075760.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Division of Gastroenterology, Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "F\u00e4rkkil\u00e4", 
        "givenName": "Martti", 
        "id": "sg:person.0633564101.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633564101.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Finland Health Care District", 
          "id": "https://www.grid.ac/institutes/grid.460356.2", 
          "name": [
            "Department ofPathology, Jyv\u00e4skyl\u00e4 Central Hospital, Jyv\u00e4skyl\u00e4, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juhola", 
        "givenName": "Matti", 
        "id": "sg:person.01247232432.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247232432.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jorvi Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414747.5", 
          "name": [
            "Department of Pathology, Jorvi Hospital, Espoo, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sipponen", 
        "givenName": "Pentti", 
        "id": "sg:person.01173045033.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173045033.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Karstula Health Centre, Karstula, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e4ntynen", 
        "givenName": "Timo", 
        "id": "sg:person.01016555432.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016555432.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1440-1746.1991.tb01468.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003988038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(94)90057-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012588971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.41.5.585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019481854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/92.6.741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031864383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5107(96)70239-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037072249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)90349-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040049226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)90349-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040049226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5107(87)71676-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043249526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.39.2.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048818578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.40.6.710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051927951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.265.10.1287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054152365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.270.11.1320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054155929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-1012937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057485663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199600001-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060121952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079631582", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(93)90420-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082801668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082941650", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-04", 
    "datePublishedReg": "1999-04-01", 
    "description": "OBJECTIVES: In Barrett's esophagus (BE) normal squamous esophageal epithelium is replaced by specialized columnar epithelium (SCE). BE is related to gastroesophageal reflux disease (GERD) and is a risk factor for esophageal adenocarcinoma. SCE is detected also at normal-appearing esophagogastric junction without BE (junctional SCE). The relationships between junctional SCE, GERD, and cardia adenocarcinoma are obscure and controversial. The aims of the present study were to investigate the prevalence and demographics of junctional SCE and to compare these figures with those reported for BE, and esophageal and cardia adenocarcinoma. A further aim was to examine the association between junctional SCE and GERD, Helicobacter pylori infection, and gastritis.\nMETHODS: One thousand one hundred-nineteen consecutive dyspeptic patients underwent gastroscopy and were enrolled into the study.\nRESULTS: Junctional SCE was detected in 110 patients (10%). The age-specific prevalence of junctional SCE increased with age. The male:female ratio was 1:1.1. In multivariate analysis, junctional SCE was independently and positively related to endoscopic erosive esophagitis (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-3.1), cardia inflammation (carditis) (OR, 3.1; 95% CI, 1.4-6.8), and age (OR, 1.4 per decade; 95% CI, 1.2-1.6), but not to corpus H. pylori infection (OR, 1.4; 95% CI, 0.7-2.8), antral (OR, 1.0; 95% CI, 0.5-2.1) or corpus (OR, 0.8; 95% CI, 0.4-1.8) gastritis, or intestinal metaplasia of the antral mucosa in stomach (OR, 1.2; 95% CI, 0.7-2.1). In univariate analysis, junctional SCE was, however, significantly more common in patients with antral-predominant atrophic gastritis (20%), compared with those with normal gastric histology (8%, p < 0.001).\nCONCLUSIONS: Junctional SCE is age related and may therefore be an acquired lesion. It is associated with cardia inflammation and endoscopic erosive esophagitis, but not with H. pylori infection or gastric intestinal metaplasia. Unlike BE and cardia cancer, junctional SCE occurs with similar frequency in men and women.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/j.1572-0241.1999.986_i.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019809", 
        "issn": [
          "0002-9270", 
          "1572-0241"
        ], 
        "name": "The American Journal of Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "94"
      }
    ], 
    "name": "Specialized columnar epithelium of the esophagogastric junction: prevalence and associations", 
    "pagination": "913", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e29f37610d611419152fbccc894bf11aa3e7d559b48ea811fbc3182292d74824"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10201456"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0421030"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1572-0241.1999.986_i.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047572521"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1572-0241.1999.986_i.x", 
      "https://app.dimensions.ai/details/publication/pub.1047572521"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ajg1999212"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.986_i.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.986_i.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.986_i.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.986_i.x'


 

This table displays all metadata directly associated to this object as RDF triples.

250 TRIPLES      21 PREDICATES      61 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1572-0241.1999.986_i.x schema:about N08edf3861d004e0782c8e833d37c49a9
2 N212020391f1f46f2b46b2065e37d289e
3 N350eab082ab24ea49348b710de75b96e
4 N37a0b18f9e5544d19d00030fa24265b1
5 N3ac72c8d829648dcbab0ec38e0130e54
6 N3c3acba5dbdd4d05b5e0a988087d1888
7 N60c5c8d053604b44ae08e6fb9bf80f21
8 N655404663744495ab34df3a6ad7ac26b
9 N65b93893cda549d4ad98846c28d19267
10 N6d9682c9b6c54bc8b64e2718efcf3e17
11 N8da711cd391f43e08621c39673dded19
12 N976500aca20d4c15b713bfb65781d723
13 Nada96bb60bbf449592f58f56a2c50a64
14 Nc3242edddce34ba6adc770d5f86db936
15 Nc339ace712774efd8c16f4d33db57007
16 Nf86540059d9940bcb82e5d41bfa1ed8e
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N9dbcd0e7c8d744529f9038b2866dadf6
20 schema:citation https://app.dimensions.ai/details/publication/pub.1079631582
21 https://app.dimensions.ai/details/publication/pub.1082941650
22 https://doi.org/10.1001/jama.265.10.1287
23 https://doi.org/10.1001/jama.270.11.1320
24 https://doi.org/10.1016/0016-5085(93)90420-h
25 https://doi.org/10.1016/0046-8177(94)90057-4
26 https://doi.org/10.1016/s0016-5107(87)71676-9
27 https://doi.org/10.1016/s0016-5107(96)70239-0
28 https://doi.org/10.1016/s0140-6736(94)90349-2
29 https://doi.org/10.1055/s-2007-1012937
30 https://doi.org/10.1093/ajcp/92.6.741
31 https://doi.org/10.1097/00000478-199600001-00005
32 https://doi.org/10.1111/j.1440-1746.1991.tb01468.x
33 https://doi.org/10.1136/gut.39.2.151
34 https://doi.org/10.1136/gut.40.6.710
35 https://doi.org/10.1136/gut.41.5.585
36 schema:datePublished 1999-04
37 schema:datePublishedReg 1999-04-01
38 schema:description OBJECTIVES: In Barrett's esophagus (BE) normal squamous esophageal epithelium is replaced by specialized columnar epithelium (SCE). BE is related to gastroesophageal reflux disease (GERD) and is a risk factor for esophageal adenocarcinoma. SCE is detected also at normal-appearing esophagogastric junction without BE (junctional SCE). The relationships between junctional SCE, GERD, and cardia adenocarcinoma are obscure and controversial. The aims of the present study were to investigate the prevalence and demographics of junctional SCE and to compare these figures with those reported for BE, and esophageal and cardia adenocarcinoma. A further aim was to examine the association between junctional SCE and GERD, Helicobacter pylori infection, and gastritis. METHODS: One thousand one hundred-nineteen consecutive dyspeptic patients underwent gastroscopy and were enrolled into the study. RESULTS: Junctional SCE was detected in 110 patients (10%). The age-specific prevalence of junctional SCE increased with age. The male:female ratio was 1:1.1. In multivariate analysis, junctional SCE was independently and positively related to endoscopic erosive esophagitis (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-3.1), cardia inflammation (carditis) (OR, 3.1; 95% CI, 1.4-6.8), and age (OR, 1.4 per decade; 95% CI, 1.2-1.6), but not to corpus H. pylori infection (OR, 1.4; 95% CI, 0.7-2.8), antral (OR, 1.0; 95% CI, 0.5-2.1) or corpus (OR, 0.8; 95% CI, 0.4-1.8) gastritis, or intestinal metaplasia of the antral mucosa in stomach (OR, 1.2; 95% CI, 0.7-2.1). In univariate analysis, junctional SCE was, however, significantly more common in patients with antral-predominant atrophic gastritis (20%), compared with those with normal gastric histology (8%, p < 0.001). CONCLUSIONS: Junctional SCE is age related and may therefore be an acquired lesion. It is associated with cardia inflammation and endoscopic erosive esophagitis, but not with H. pylori infection or gastric intestinal metaplasia. Unlike BE and cardia cancer, junctional SCE occurs with similar frequency in men and women.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree false
42 schema:isPartOf N5ef89f62f18949ee98de7e4be958911b
43 N8fcdfb4eb9704a1ab57472e3d527ef7e
44 sg:journal.1019809
45 schema:name Specialized columnar epithelium of the esophagogastric junction: prevalence and associations
46 schema:pagination 913
47 schema:productId N589fb8970c79488085ba550437252c1a
48 N7a5f6372bd3f48b0a7d906361a1aaa9e
49 Nb4291571498945c99f1cc2ac6b363d48
50 Nee2de5b8720e4888af56407c91ff0c37
51 Nee608f70368d4137ad5686f7679ed10a
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047572521
53 https://doi.org/10.1111/j.1572-0241.1999.986_i.x
54 schema:sdDatePublished 2019-04-10T12:59
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher N229865636eba4d0387799b8d5d95aa8f
57 schema:url https://www.nature.com/articles/ajg1999212
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N08edf3861d004e0782c8e833d37c49a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Gastroesophageal Reflux
63 rdf:type schema:DefinedTerm
64 N1858980e6943424ea1fff685bc91fafa rdf:first sg:person.0612075760.26
65 rdf:rest N4e38dfd2738f4f6b913d563d250efaff
66 N212020391f1f46f2b46b2065e37d289e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Helicobacter pylori
68 rdf:type schema:DefinedTerm
69 N229865636eba4d0387799b8d5d95aa8f schema:name Springer Nature - SN SciGraph project
70 rdf:type schema:Organization
71 N350eab082ab24ea49348b710de75b96e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Female
73 rdf:type schema:DefinedTerm
74 N37a0b18f9e5544d19d00030fa24265b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Prevalence
76 rdf:type schema:DefinedTerm
77 N3ac72c8d829648dcbab0ec38e0130e54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Esophagogastric Junction
79 rdf:type schema:DefinedTerm
80 N3c3acba5dbdd4d05b5e0a988087d1888 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Middle Aged
82 rdf:type schema:DefinedTerm
83 N4e38dfd2738f4f6b913d563d250efaff rdf:first sg:person.0633564101.65
84 rdf:rest Ncc378a0640604668919d7dde75b39467
85 N5451c316ea37425a92b1a0ce383e8b22 rdf:first sg:person.0613721554.41
86 rdf:rest Ndf291056c73a405ca1d0401c19983675
87 N589fb8970c79488085ba550437252c1a schema:name dimensions_id
88 schema:value pub.1047572521
89 rdf:type schema:PropertyValue
90 N5ef89f62f18949ee98de7e4be958911b schema:issueNumber 4
91 rdf:type schema:PublicationIssue
92 N60c5c8d053604b44ae08e6fb9bf80f21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Sex Factors
94 rdf:type schema:DefinedTerm
95 N655404663744495ab34df3a6ad7ac26b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Gastritis
97 rdf:type schema:DefinedTerm
98 N65b93893cda549d4ad98846c28d19267 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Male
100 rdf:type schema:DefinedTerm
101 N6d9682c9b6c54bc8b64e2718efcf3e17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Helicobacter Infections
103 rdf:type schema:DefinedTerm
104 N7a5f6372bd3f48b0a7d906361a1aaa9e schema:name nlm_unique_id
105 schema:value 0421030
106 rdf:type schema:PropertyValue
107 N8da711cd391f43e08621c39673dded19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aged
109 rdf:type schema:DefinedTerm
110 N8fcdfb4eb9704a1ab57472e3d527ef7e schema:volumeNumber 94
111 rdf:type schema:PublicationVolume
112 N91956c9ea7514265afc19fb872573c61 rdf:first sg:person.01016555432.43
113 rdf:rest rdf:nil
114 N976500aca20d4c15b713bfb65781d723 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Finland
116 rdf:type schema:DefinedTerm
117 N9dbcd0e7c8d744529f9038b2866dadf6 rdf:first sg:person.01010044564.26
118 rdf:rest N9fdc0aaa494b4896be76825cb4accfe2
119 N9fdc0aaa494b4896be76825cb4accfe2 rdf:first sg:person.0753761213.35
120 rdf:rest N5451c316ea37425a92b1a0ce383e8b22
121 Na89285ad3d104792807249c893a689e1 schema:name Karstula Health Centre, Karstula, Finland
122 rdf:type schema:Organization
123 Nada96bb60bbf449592f58f56a2c50a64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Biopsy
125 rdf:type schema:DefinedTerm
126 Nb4291571498945c99f1cc2ac6b363d48 schema:name pubmed_id
127 schema:value 10201456
128 rdf:type schema:PropertyValue
129 Nb8b7261415554ed5a618b3f42295a86c schema:name Karstula Health Centre, Karstula, Finland
130 rdf:type schema:Organization
131 Nc3242edddce34ba6adc770d5f86db936 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Nc339ace712774efd8c16f4d33db57007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Barrett Esophagus
136 rdf:type schema:DefinedTerm
137 Ncc378a0640604668919d7dde75b39467 rdf:first sg:person.01247232432.12
138 rdf:rest Ncd846d47623c48508c866145ad1aef1c
139 Ncd846d47623c48508c866145ad1aef1c rdf:first sg:person.01173045033.23
140 rdf:rest N91956c9ea7514265afc19fb872573c61
141 Ndf291056c73a405ca1d0401c19983675 rdf:first sg:person.01151670313.18
142 rdf:rest N1858980e6943424ea1fff685bc91fafa
143 Nee2de5b8720e4888af56407c91ff0c37 schema:name readcube_id
144 schema:value e29f37610d611419152fbccc894bf11aa3e7d559b48ea811fbc3182292d74824
145 rdf:type schema:PropertyValue
146 Nee608f70368d4137ad5686f7679ed10a schema:name doi
147 schema:value 10.1111/j.1572-0241.1999.986_i.x
148 rdf:type schema:PropertyValue
149 Nf86540059d9940bcb82e5d41bfa1ed8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Age Factors
151 rdf:type schema:DefinedTerm
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
156 schema:name Clinical Sciences
157 rdf:type schema:DefinedTerm
158 sg:journal.1019809 schema:issn 0002-9270
159 1572-0241
160 schema:name The American Journal of Gastroenterology
161 rdf:type schema:Periodical
162 sg:person.01010044564.26 schema:affiliation Na89285ad3d104792807249c893a689e1
163 schema:familyName Kunnamo
164 schema:givenName Ilkka
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010044564.26
166 rdf:type schema:Person
167 sg:person.01016555432.43 schema:affiliation Nb8b7261415554ed5a618b3f42295a86c
168 schema:familyName Mäntynen
169 schema:givenName Timo
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016555432.43
171 rdf:type schema:Person
172 sg:person.01151670313.18 schema:affiliation https://www.grid.ac/institutes/grid.460356.2
173 schema:familyName Nuorva
174 schema:givenName Kyösti
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151670313.18
176 rdf:type schema:Person
177 sg:person.01173045033.23 schema:affiliation https://www.grid.ac/institutes/grid.414747.5
178 schema:familyName Sipponen
179 schema:givenName Pentti
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173045033.23
181 rdf:type schema:Person
182 sg:person.01247232432.12 schema:affiliation https://www.grid.ac/institutes/grid.460356.2
183 schema:familyName Juhola
184 schema:givenName Matti
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247232432.12
186 rdf:type schema:Person
187 sg:person.0612075760.26 schema:affiliation https://www.grid.ac/institutes/grid.460356.2
188 schema:familyName Voutilainen
189 schema:givenName Markku
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612075760.26
191 rdf:type schema:Person
192 sg:person.0613721554.41 schema:affiliation https://www.grid.ac/institutes/grid.9668.1
193 schema:familyName Mauranen
194 schema:givenName Kari
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613721554.41
196 rdf:type schema:Person
197 sg:person.0633564101.65 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
198 schema:familyName Färkkilä
199 schema:givenName Martti
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633564101.65
201 rdf:type schema:Person
202 sg:person.0753761213.35 schema:affiliation https://www.grid.ac/institutes/grid.460356.2
203 schema:familyName Mecklin
204 schema:givenName Jukka-Pekka
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753761213.35
206 rdf:type schema:Person
207 https://app.dimensions.ai/details/publication/pub.1079631582 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1082941650 schema:CreativeWork
209 https://doi.org/10.1001/jama.265.10.1287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054152365
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1001/jama.270.11.1320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054155929
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0016-5085(93)90420-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1082801668
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0046-8177(94)90057-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012588971
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0016-5107(87)71676-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043249526
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0016-5107(96)70239-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037072249
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0140-6736(94)90349-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040049226
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1055/s-2007-1012937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057485663
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1093/ajcp/92.6.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031864383
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1097/00000478-199600001-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060121952
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/j.1440-1746.1991.tb01468.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003988038
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1136/gut.39.2.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048818578
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1136/gut.40.6.710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051927951
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1136/gut.41.5.585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019481854
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.15485.3d schema:alternateName Helsinki University Central Hospital
238 schema:name Division of Gastroenterology, Department of Internal Medicine, Helsinki University Hospital, Helsinki, Finland
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.414747.5 schema:alternateName Jorvi Hospital
241 schema:name Department of Pathology, Jorvi Hospital, Espoo, Finland
242 rdf:type schema:Organization
243 https://www.grid.ac/institutes/grid.460356.2 schema:alternateName Central Finland Health Care District
244 schema:name Department of Internal Medicine Jyväskylä Central Hospital, Jyväskylä, Finland
245 Department ofPathology, Jyväskylä Central Hospital, Jyväskylä, Finland
246 Department ofSurgery, Jyväskylä Central Hospital, Jyväskylä, Finland
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.9668.1 schema:alternateName University of Eastern Finland
249 schema:name Department of Health Policy and Management, Kuopio University, Kuopio, Finland
250 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...