Ontology type: schema:ScholarlyArticle
1999-10-01
AUTHORSKazuhiko Hayashi, Takashi Kumada, Satoshi Nakano, Isao Takeda, Keiichi Sugiyama, Seiki Kiriyama, Yasuhiro Sone, Akihiro Miyata, Hideyuki Shimizu, Shinji Satomura
ABSTRACTOBJECTIVE: Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3%) is a recently described marker of hepatocellular carcinoma (HCC), and its usefulness has been demonstrated in many studies. We evaluated the usefulness of serial measurement of AFP-L3% as a marker of prognosis and recurrence after treatment of small HCC. METHODS: AFP-L3% was measured before and after initial treatment in 60 patients with small HCC (maximum diameter < or = 2 cm). AFP-L3% was taken as the ratio of AFP-L3 to total AFP and multiplied by 100%, and levels > or = 10% were considered positive. Outcomes and recurrence were compared between patients AFP-L3%-negative after initial treatment (Group A, n = 43) and patients who were AFP-L3%-positive after initial treatment (Group B, n = 17). RESULTS: Before treatment, AFP-L3% was positive in 14 (23.3%) of the 60 patients. The cumulative survival rate of Group A was significantly longer (p = 0.0091) than that of Group B. The recurrence rate was significantly higher in Group B (p = 0.0104) than in Group A. When recurrence was limited to intrahepatic metastasis, the recurrence rate was significantly higher in Group B (p = 0.0064). However, the recurrence rate of multicentric occurrence did not differ significantly between Groups A and B. CONCLUSIONS: Measurement of AFP-L3% after treatment may be useful for understanding prognosis and recurrence of HCC. More... »
PAGESajg1999673
http://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.01378.x
DOIhttp://dx.doi.org/10.1111/j.1572-0241.1999.01378.x
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10520864
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