Effect of low and high fat meals on lower esophageal sphincter motility and gastroesophageal reflux in healthy subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-05

AUTHORS

C Pehl, A Waizenhoefer, B Wendl, T Schmidt, W Schepp, A Pfeiffer

ABSTRACT

OBJECTIVE: The reported effects of fatty meals on lower esophageal sphincter pressure (LESP) and gastroesophageal reflux (GER) are controversial. Therefore, the aim of the present study was to reevaluate the effect of isocaloric and isovolumetric low and high fat meals on LESP and GER. METHODS: Twelve healthy volunteers (six women, six men, 19 to 31 yr) received an isocaloric (842 kcal) solid-liquid (310 ml with 260 kcal) meal with either a low (10% fat, 14% proteins, 76% carbohydrates) or a high fat content (50% fat, 18% proteins, 32% carbohydrates) in a randomized, double-blinded fashion. The nutritional composition was identical for the solid and liquid part of the meals. In the first post-prandial hour LESP was recorded continuously using a Dent sleeve, and esophageal pH measurement was performed for 3 h postprandially with a glass electrode. We calculated the mean LESP, the frequency of transient LES relaxations (TLESR) and of reflux episodes (RE), the percentage of TLESR with GER, and the fraction time pH <4. RESULTS: For all parameters measured no difference was observed between the low and the high fat meal. Mean LESP amounted to a median of 10.7 mm Hg (range, 7.3 to 15.1 mm Hg) after the low fat meal and to 11.1 mm Hg (5.2 to 16.3 mm Hg) after the high fat meal. The frequency of TLESR (n/1 h) rated to 9 (5 to 13) and 8 (4 to 14), and of RE (n/3 h) to 12 (3 to 22) and 11 (1 to 30). The percentage of TLESR with GER were 37% (0 to 100) and 30% (0 to 78). The fraction time pH <4 amounted to 2.3% (0.2 to 23.7) and 1.8% (0.1 to 28.8) after the low and high fat meal, respectively. CONCLUSIONS: In healthy volunteers no difference in post-prandial LESP and GER was seen after a high fat meal compared with an isocaloric and isovolumetric low fat meal. Our results suggest that it is inappropriate to advise GER patients to reduce the fat content of their meals for symptom relief. More... »

PAGES

ajg1999287

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.01064.x

DOI

http://dx.doi.org/10.1111/j.1572-0241.1999.01064.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033321009

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10235191


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Fats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Energy Intake", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Esophagogastric Junction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Esophagus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastroesophageal Reflux", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen-Ion Concentration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Manometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reference Values", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pehl", 
        "givenName": "C", 
        "id": "sg:person.0645730206.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645730206.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waizenhoefer", 
        "givenName": "A", 
        "id": "sg:person.0630673450.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630673450.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wendl", 
        "givenName": "B", 
        "id": "sg:person.01144344736.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144344736.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt", 
        "givenName": "T", 
        "id": "sg:person.0605741476.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schepp", 
        "givenName": "W", 
        "id": "sg:person.01137535642.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137535642.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology and Hepatology, Municipal Hospital, Memingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfeiffer", 
        "givenName": "A", 
        "id": "sg:person.0646224431.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646224431.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01071988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000397349", 
          "https://doi.org/10.1007/bf01071988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01071988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000397349", 
          "https://doi.org/10.1007/bf01071988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198212163072503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003167227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(95)90011-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003364829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197610000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005175204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-197610000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005175204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v110.pm8608873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008816922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1997.sp021881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011140066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(95)90351-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015327786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02091532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018125608", 
          "https://doi.org/10.1007/bf02091532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02091532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018125608", 
          "https://doi.org/10.1007/bf02091532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018874800819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021855302", 
          "https://doi.org/10.1023/a:1018874800819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01313584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028080713", 
          "https://doi.org/10.1007/bf01313584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01313584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028080713", 
          "https://doi.org/10.1007/bf01313584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci109667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030551295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.29.8.1020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032212320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70139-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036470074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70139-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036470074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01297443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037614594", 
          "https://doi.org/10.1007/bf01297443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01297443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037614594", 
          "https://doi.org/10.1007/bf01297443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.42.3.330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038173530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.40.4.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038961808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-017-4389-1_48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040849773", 
          "https://doi.org/10.1007/978-94-017-4389-1_48"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01296157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041583531", 
          "https://doi.org/10.1007/bf01296157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01296157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041583531", 
          "https://doi.org/10.1007/bf01296157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365529850166815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042059998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(85)90572-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042387306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.18.9.709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045618306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.1994.tb00170.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046393996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.1994.tb00170.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046393996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.40.5.575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047552870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(88)80003-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049074805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.14.4.270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050387332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0025-7125(16)31470-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053106190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077107031", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079300958", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079301529", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1987.252.5.g636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079832283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079960573", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080794713", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083182934", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-05", 
    "datePublishedReg": "1999-05-01", 
    "description": "OBJECTIVE: The reported effects of fatty meals on lower esophageal sphincter pressure (LESP) and gastroesophageal reflux (GER) are controversial. Therefore, the aim of the present study was to reevaluate the effect of isocaloric and isovolumetric low and high fat meals on LESP and GER.\nMETHODS: Twelve healthy volunteers (six women, six men, 19 to 31 yr) received an isocaloric (842 kcal) solid-liquid (310 ml with 260 kcal) meal with either a low (10% fat, 14% proteins, 76% carbohydrates) or a high fat content (50% fat, 18% proteins, 32% carbohydrates) in a randomized, double-blinded fashion. The nutritional composition was identical for the solid and liquid part of the meals. In the first post-prandial hour LESP was recorded continuously using a Dent sleeve, and esophageal pH measurement was performed for 3 h postprandially with a glass electrode. We calculated the mean LESP, the frequency of transient LES relaxations (TLESR) and of reflux episodes (RE), the percentage of TLESR with GER, and the fraction time pH <4.\nRESULTS: For all parameters measured no difference was observed between the low and the high fat meal. Mean LESP amounted to a median of 10.7 mm Hg (range, 7.3 to 15.1 mm Hg) after the low fat meal and to 11.1 mm Hg (5.2 to 16.3 mm Hg) after the high fat meal. The frequency of TLESR (n/1 h) rated to 9 (5 to 13) and 8 (4 to 14), and of RE (n/3 h) to 12 (3 to 22) and 11 (1 to 30). The percentage of TLESR with GER were 37% (0 to 100) and 30% (0 to 78). The fraction time pH <4 amounted to 2.3% (0.2 to 23.7) and 1.8% (0.1 to 28.8) after the low and high fat meal, respectively.\nCONCLUSIONS: In healthy volunteers no difference in post-prandial LESP and GER was seen after a high fat meal compared with an isocaloric and isovolumetric low fat meal. Our results suggest that it is inappropriate to advise GER patients to reduce the fat content of their meals for symptom relief.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/j.1572-0241.1999.01064.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019809", 
        "issn": [
          "0002-9270", 
          "1572-0241"
        ], 
        "name": "The American Journal of Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "94"
      }
    ], 
    "name": "Effect of low and high fat meals on lower esophageal sphincter motility and gastroesophageal reflux in healthy subjects", 
    "pagination": "ajg1999287", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9ebc63332546d278e63f21fa442e4b3618a8a3556f3ac6e19abba1f9c5f25f79"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10235191"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0421030"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1572-0241.1999.01064.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033321009"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1572-0241.1999.01064.x", 
      "https://app.dimensions.ai/details/publication/pub.1033321009"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000357_0000000357/records_99293_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ajg1999287"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.01064.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.01064.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.01064.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1572-0241.1999.01064.x'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      76 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1572-0241.1999.01064.x schema:about N15d9d8a181974788b4d65996cc8cd1ee
2 N1e9af7295a4b4508914f7c936b7a6462
3 N33f682657d10479982c207d43b0b0791
4 N7a029227237243b39eea3254a9ded9fa
5 N7a2f44ea20fe4f3799f1479502602a42
6 N876b5fda1d1e48668d38cb5c338a1000
7 N9a2a624fd92d41e2bd14e0c4e5d0e424
8 Nc304a08ed0994e01bd930642ad08ac4d
9 Nc4892f5a05844f4a9faa83aba9df9bba
10 Ncbcf89fae905487cb760067d9d2dc749
11 Nda4f67cac05b4295b0e2887ab3302799
12 Ne1e8d3d038384f1f8ae883debee5dc7b
13 Ne68f748e6890499dbcde67d367ddabff
14 Nf2acf9285b3f4245b2d7c697f070fe62
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nf23b790b25df4592b31121e7f6e781a7
18 schema:citation sg:pub.10.1007/978-94-017-4389-1_48
19 sg:pub.10.1007/bf01071988
20 sg:pub.10.1007/bf01296157
21 sg:pub.10.1007/bf01297443
22 sg:pub.10.1007/bf01313584
23 sg:pub.10.1007/bf02091532
24 sg:pub.10.1023/a:1018874800819
25 https://app.dimensions.ai/details/publication/pub.1077107031
26 https://app.dimensions.ai/details/publication/pub.1079300958
27 https://app.dimensions.ai/details/publication/pub.1079301529
28 https://app.dimensions.ai/details/publication/pub.1079960573
29 https://app.dimensions.ai/details/publication/pub.1080794713
30 https://app.dimensions.ai/details/publication/pub.1083182934
31 https://doi.org/10.1016/0016-5085(85)90572-4
32 https://doi.org/10.1016/0016-5085(95)90011-x
33 https://doi.org/10.1016/0016-5085(95)90351-8
34 https://doi.org/10.1016/s0016-5085(88)80003-9
35 https://doi.org/10.1016/s0016-5085(98)70139-8
36 https://doi.org/10.1016/s0025-7125(16)31470-5
37 https://doi.org/10.1053/gast.1996.v110.pm8608873
38 https://doi.org/10.1056/nejm198212163072503
39 https://doi.org/10.1080/00365529850166815
40 https://doi.org/10.1097/00000658-197610000-00009
41 https://doi.org/10.1111/j.1365-2982.1994.tb00170.x
42 https://doi.org/10.1113/jphysiol.1997.sp021881
43 https://doi.org/10.1136/gut.14.4.270
44 https://doi.org/10.1136/gut.18.9.709
45 https://doi.org/10.1136/gut.29.8.1020
46 https://doi.org/10.1136/gut.40.4.449
47 https://doi.org/10.1136/gut.40.5.575
48 https://doi.org/10.1136/gut.42.3.330
49 https://doi.org/10.1152/ajpgi.1987.252.5.g636
50 https://doi.org/10.1172/jci109667
51 schema:datePublished 1999-05
52 schema:datePublishedReg 1999-05-01
53 schema:description OBJECTIVE: The reported effects of fatty meals on lower esophageal sphincter pressure (LESP) and gastroesophageal reflux (GER) are controversial. Therefore, the aim of the present study was to reevaluate the effect of isocaloric and isovolumetric low and high fat meals on LESP and GER. METHODS: Twelve healthy volunteers (six women, six men, 19 to 31 yr) received an isocaloric (842 kcal) solid-liquid (310 ml with 260 kcal) meal with either a low (10% fat, 14% proteins, 76% carbohydrates) or a high fat content (50% fat, 18% proteins, 32% carbohydrates) in a randomized, double-blinded fashion. The nutritional composition was identical for the solid and liquid part of the meals. In the first post-prandial hour LESP was recorded continuously using a Dent sleeve, and esophageal pH measurement was performed for 3 h postprandially with a glass electrode. We calculated the mean LESP, the frequency of transient LES relaxations (TLESR) and of reflux episodes (RE), the percentage of TLESR with GER, and the fraction time pH <4. RESULTS: For all parameters measured no difference was observed between the low and the high fat meal. Mean LESP amounted to a median of 10.7 mm Hg (range, 7.3 to 15.1 mm Hg) after the low fat meal and to 11.1 mm Hg (5.2 to 16.3 mm Hg) after the high fat meal. The frequency of TLESR (n/1 h) rated to 9 (5 to 13) and 8 (4 to 14), and of RE (n/3 h) to 12 (3 to 22) and 11 (1 to 30). The percentage of TLESR with GER were 37% (0 to 100) and 30% (0 to 78). The fraction time pH <4 amounted to 2.3% (0.2 to 23.7) and 1.8% (0.1 to 28.8) after the low and high fat meal, respectively. CONCLUSIONS: In healthy volunteers no difference in post-prandial LESP and GER was seen after a high fat meal compared with an isocaloric and isovolumetric low fat meal. Our results suggest that it is inappropriate to advise GER patients to reduce the fat content of their meals for symptom relief.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N460a30b669e346a8a2b1a6082e081009
58 N4c6fb8ed9daa40158a013d7831dd9d99
59 sg:journal.1019809
60 schema:name Effect of low and high fat meals on lower esophageal sphincter motility and gastroesophageal reflux in healthy subjects
61 schema:pagination ajg1999287
62 schema:productId N1327140f8fb6431a90433914b22749aa
63 N64371c2f938b43f49ed2ea18503dcc14
64 N7d3e9f9aeb754aaaa8d1d852da43a188
65 Nbe447e24985e4d13a6d5f81f8c5f24c3
66 Nf9d583993a644112919f46e59a6fa473
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033321009
68 https://doi.org/10.1111/j.1572-0241.1999.01064.x
69 schema:sdDatePublished 2019-04-11T11:29
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N668c94769d2c4ce29c3bda01b068c18b
72 schema:url http://www.nature.com/articles/ajg1999287
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N069030dfecae4c448c6e8be9b37e78b9 schema:name Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany
77 rdf:type schema:Organization
78 N0eafb94e1b49403ba74252a2cc574fb1 rdf:first sg:person.0646224431.41
79 rdf:rest rdf:nil
80 N1327140f8fb6431a90433914b22749aa schema:name nlm_unique_id
81 schema:value 0421030
82 rdf:type schema:PropertyValue
83 N15d9d8a181974788b4d65996cc8cd1ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Manometry
85 rdf:type schema:DefinedTerm
86 N1863bf1753b74465809ecb0f6e18be10 schema:name Department of Gastroenterology and Hepatology, Municipal Hospital, Memingen, Germany
87 rdf:type schema:Organization
88 N1e9af7295a4b4508914f7c936b7a6462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Esophagus
90 rdf:type schema:DefinedTerm
91 N251727cdacda4a11ae4571bc1c094908 rdf:first sg:person.0605741476.97
92 rdf:rest N4605c26fd09e479799aa5c64fba2b996
93 N314cf18638944d97b3d91e545795a7bd schema:name Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany
94 rdf:type schema:Organization
95 N33f682657d10479982c207d43b0b0791 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N4605c26fd09e479799aa5c64fba2b996 rdf:first sg:person.01137535642.21
99 rdf:rest N0eafb94e1b49403ba74252a2cc574fb1
100 N460a30b669e346a8a2b1a6082e081009 schema:volumeNumber 94
101 rdf:type schema:PublicationVolume
102 N4c6fb8ed9daa40158a013d7831dd9d99 schema:issueNumber 5
103 rdf:type schema:PublicationIssue
104 N64371c2f938b43f49ed2ea18503dcc14 schema:name doi
105 schema:value 10.1111/j.1572-0241.1999.01064.x
106 rdf:type schema:PropertyValue
107 N668c94769d2c4ce29c3bda01b068c18b schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N7a029227237243b39eea3254a9ded9fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Double-Blind Method
111 rdf:type schema:DefinedTerm
112 N7a2f44ea20fe4f3799f1479502602a42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Pressure
114 rdf:type schema:DefinedTerm
115 N7d3e9f9aeb754aaaa8d1d852da43a188 schema:name pubmed_id
116 schema:value 10235191
117 rdf:type schema:PropertyValue
118 N876b5fda1d1e48668d38cb5c338a1000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Male
120 rdf:type schema:DefinedTerm
121 N8ac8b7f34d9c4638947c1324c7ae5b78 schema:name Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany
122 rdf:type schema:Organization
123 N9a2a624fd92d41e2bd14e0c4e5d0e424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Dietary Fats
125 rdf:type schema:DefinedTerm
126 Na2f107d354874c22a8d55c7ec72538d2 schema:name Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany
127 rdf:type schema:Organization
128 Nb5c07682d15a4dca82dc86520489a476 rdf:first sg:person.0630673450.34
129 rdf:rest Nbbe0f04c84f542eda0a68bd46b0545e2
130 Nbbe0f04c84f542eda0a68bd46b0545e2 rdf:first sg:person.01144344736.32
131 rdf:rest N251727cdacda4a11ae4571bc1c094908
132 Nbe447e24985e4d13a6d5f81f8c5f24c3 schema:name readcube_id
133 schema:value 9ebc63332546d278e63f21fa442e4b3618a8a3556f3ac6e19abba1f9c5f25f79
134 rdf:type schema:PropertyValue
135 Nc304a08ed0994e01bd930642ad08ac4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Adult
137 rdf:type schema:DefinedTerm
138 Nc4892f5a05844f4a9faa83aba9df9bba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Reference Values
140 rdf:type schema:DefinedTerm
141 Ncbcf89fae905487cb760067d9d2dc749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Hydrogen-Ion Concentration
143 rdf:type schema:DefinedTerm
144 Nd8994e1c49644e309f8b6aebcf075ff6 schema:name Department of Gastroenterology and Hepatology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany
145 rdf:type schema:Organization
146 Nda4f67cac05b4295b0e2887ab3302799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Esophagogastric Junction
148 rdf:type schema:DefinedTerm
149 Ne1e8d3d038384f1f8ae883debee5dc7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Energy Intake
151 rdf:type schema:DefinedTerm
152 Ne68f748e6890499dbcde67d367ddabff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Gastroesophageal Reflux
154 rdf:type schema:DefinedTerm
155 Nf23b790b25df4592b31121e7f6e781a7 rdf:first sg:person.0645730206.80
156 rdf:rest Nb5c07682d15a4dca82dc86520489a476
157 Nf2acf9285b3f4245b2d7c697f070fe62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 Nf9d583993a644112919f46e59a6fa473 schema:name dimensions_id
161 schema:value pub.1033321009
162 rdf:type schema:PropertyValue
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
167 schema:name Clinical Sciences
168 rdf:type schema:DefinedTerm
169 sg:journal.1019809 schema:issn 0002-9270
170 1572-0241
171 schema:name The American Journal of Gastroenterology
172 rdf:type schema:Periodical
173 sg:person.01137535642.21 schema:affiliation Nd8994e1c49644e309f8b6aebcf075ff6
174 schema:familyName Schepp
175 schema:givenName W
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137535642.21
177 rdf:type schema:Person
178 sg:person.01144344736.32 schema:affiliation N8ac8b7f34d9c4638947c1324c7ae5b78
179 schema:familyName Wendl
180 schema:givenName B
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144344736.32
182 rdf:type schema:Person
183 sg:person.0605741476.97 schema:affiliation N069030dfecae4c448c6e8be9b37e78b9
184 schema:familyName Schmidt
185 schema:givenName T
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97
187 rdf:type schema:Person
188 sg:person.0630673450.34 schema:affiliation N314cf18638944d97b3d91e545795a7bd
189 schema:familyName Waizenhoefer
190 schema:givenName A
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630673450.34
192 rdf:type schema:Person
193 sg:person.0645730206.80 schema:affiliation Na2f107d354874c22a8d55c7ec72538d2
194 schema:familyName Pehl
195 schema:givenName C
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645730206.80
197 rdf:type schema:Person
198 sg:person.0646224431.41 schema:affiliation N1863bf1753b74465809ecb0f6e18be10
199 schema:familyName Pfeiffer
200 schema:givenName A
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646224431.41
202 rdf:type schema:Person
203 sg:pub.10.1007/978-94-017-4389-1_48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040849773
204 https://doi.org/10.1007/978-94-017-4389-1_48
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/bf01071988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000397349
207 https://doi.org/10.1007/bf01071988
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/bf01296157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041583531
210 https://doi.org/10.1007/bf01296157
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/bf01297443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037614594
213 https://doi.org/10.1007/bf01297443
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/bf01313584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028080713
216 https://doi.org/10.1007/bf01313584
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/bf02091532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018125608
219 https://doi.org/10.1007/bf02091532
220 rdf:type schema:CreativeWork
221 sg:pub.10.1023/a:1018874800819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021855302
222 https://doi.org/10.1023/a:1018874800819
223 rdf:type schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1077107031 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1079300958 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1079301529 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1079960573 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1080794713 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1083182934 schema:CreativeWork
230 https://doi.org/10.1016/0016-5085(85)90572-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042387306
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0016-5085(95)90011-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003364829
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0016-5085(95)90351-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015327786
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0016-5085(88)80003-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049074805
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0016-5085(98)70139-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036470074
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0025-7125(16)31470-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053106190
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1053/gast.1996.v110.pm8608873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008816922
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejm198212163072503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003167227
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1080/00365529850166815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042059998
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1097/00000658-197610000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005175204
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1365-2982.1994.tb00170.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046393996
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1113/jphysiol.1997.sp021881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011140066
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1136/gut.14.4.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050387332
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1136/gut.18.9.709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045618306
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1136/gut.29.8.1020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032212320
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1136/gut.40.4.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038961808
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1136/gut.40.5.575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047552870
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1136/gut.42.3.330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038173530
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1152/ajpgi.1987.252.5.g636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079832283
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1172/jci109667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030551295
269 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...