Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antibody in injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-02

AUTHORS

Elizabeth G Dean, Gabrielle R A Wilson, Ming Li, Kristy L Edgtton, Kim M O'Sullivan, Billy G Hudson, Stephen R Holdsworth, A Richard Kitching

ABSTRACT

BACKGROUND: Goodpasture's disease [antiglomerular basement membrane (GBM) glomerulonephritis] is a classic autoimmune disease and the only organ-specific autoimmune renal disease in which the antigen is well described. The importance of antibodies against the non-collagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] is well established. However, observational human studies and studies in experimental systems also imply a role for cell-mediated effector injury. METHODS: Active experimental autoimmune glomerulonephritis (EAG) was induced by immunization with alpha3-alpha5(IV)NC1 heterodimers in B cell intact C57BL/6 mice and B cell (mu chain-deficient) mice. Passive disease was induced by transferring sera from B cell intact and B cell deficient mice with EAG to RAG-1-/- mice (that lack adaptive immunity). Histologic and functional injury was studied. RESULTS: Despite the absence of B cells and immunoglobulin in B-cell-deficient mice, histologic and functional injury developed in mice immunized with alpha3-alpha5(IV)NC1, with T cells and macrophages in glomeruli. Injury occurred to a similar degree to that found in B-cell-intact mice. Transfer of sera from B-cell-intact mice with EAG containing antibodies (but not from B-cell-deficient mice with EAG) to RAG-1-/- mice induced linear immunoglobulin deposits on the glomerular basement membrane (GBM) and pathologic proteinuria. CONCLUSION: Both cell-mediated and humoral effectors are capable of inducing renal injury in EAG. Given the similarity of the disease-initiating antigen in this model to the antigen in human anti-GBM glomerulonephritis, similar overlapping mechanisms are likely to operate in human disease. More... »

PAGES

566-575

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.67113.x

DOI

http://dx.doi.org/10.1111/j.1523-1755.2005.67113.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051298417

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15673304


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Glomerular Basement Membrane Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteinuria", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dean", 
        "givenName": "Elizabeth G", 
        "type": "Person"
      }, 
      {
        "familyName": "Wilson", 
        "givenName": "Gabrielle R A", 
        "id": "sg:person.0623077762.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623077762.94"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Li", 
        "givenName": "Ming", 
        "id": "sg:person.01100567204.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100567204.52"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Edgtton", 
        "givenName": "Kristy L", 
        "id": "sg:person.01234647517.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234647517.99"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "O'Sullivan", 
        "givenName": "Kim M", 
        "id": "sg:person.0613244032.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613244032.33"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hudson", 
        "givenName": "Billy G", 
        "id": "sg:person.01233643032.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233643032.17"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Holdsworth", 
        "givenName": "Stephen R", 
        "id": "sg:person.01131260677.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kitching", 
        "givenName": "A Richard", 
        "id": "sg:person.0700603677.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603677.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.182.4.915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000094639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.126.6.989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000363832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.13.6201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003670619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci13876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006600454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90030-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007090770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011137122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m207769200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014298291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2003.00227.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017362991", 
          "https://doi.org/10.1046/j.1523-1755.2003.00227.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1523-1755.2003.00227.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017362991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci111328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017924244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2002.00312.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018318074", 
          "https://doi.org/10.1046/j.1523-1755.2002.00312.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/350423a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018596250", 
          "https://doi.org/10.1038/350423a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra022296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021861051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022776985", 
          "https://doi.org/10.1038/ki.1997.12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024809789", 
          "https://doi.org/10.1038/ki.1986.238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025518790", 
          "https://doi.org/10.1038/ki.1987.123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025529346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025839659", 
          "https://doi.org/10.1038/ki.1989.228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.23.2981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027630614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90227-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028048973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90227-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028048973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029360728", 
          "https://doi.org/10.1038/ki.1992.221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.1995.tb03663.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029948359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031598987", 
          "https://doi.org/10.1038/ki.1997.97"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1996.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034811849", 
          "https://doi.org/10.1038/ki.1996.163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.27.17023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035206830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.02-0746com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035604027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036208764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.180.4.1295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036738268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711580410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039910951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711580410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039910951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci4876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041291912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)90413-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045957451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)90413-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045957451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199901)29:01<1::aid-immu1>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048215846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-4141(199901)29:01<1::aid-immu1>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048215846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1999.00369.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049544773", 
          "https://doi.org/10.1046/j.1523-1755.1999.00369.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m211951200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050447449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2003.00241.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051214007", 
          "https://doi.org/10.1046/j.1523-1755.2003.00241.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1523-1755.2003.00241.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051214007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000091588.80007.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000091588.80007.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000091588.80007.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000128968.27705.5e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000128968.27705.5e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000128968.27705.5e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5353.1052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062559556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci15285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063415357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci15918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063415457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-134-11-200106050-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073704554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074869225", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074985310", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1985.249.2.f241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079587426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079720163", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080110209", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083115856", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083284945", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-02", 
    "datePublishedReg": "2005-02-01", 
    "description": "BACKGROUND: Goodpasture's disease [antiglomerular basement membrane (GBM) glomerulonephritis] is a classic autoimmune disease and the only organ-specific autoimmune renal disease in which the antigen is well described. The importance of antibodies against the non-collagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] is well established. However, observational human studies and studies in experimental systems also imply a role for cell-mediated effector injury.\nMETHODS: Active experimental autoimmune glomerulonephritis (EAG) was induced by immunization with alpha3-alpha5(IV)NC1 heterodimers in B cell intact C57BL/6 mice and B cell (mu chain-deficient) mice. Passive disease was induced by transferring sera from B cell intact and B cell deficient mice with EAG to RAG-1-/- mice (that lack adaptive immunity). Histologic and functional injury was studied.\nRESULTS: Despite the absence of B cells and immunoglobulin in B-cell-deficient mice, histologic and functional injury developed in mice immunized with alpha3-alpha5(IV)NC1, with T cells and macrophages in glomeruli. Injury occurred to a similar degree to that found in B-cell-intact mice. Transfer of sera from B-cell-intact mice with EAG containing antibodies (but not from B-cell-deficient mice with EAG) to RAG-1-/- mice induced linear immunoglobulin deposits on the glomerular basement membrane (GBM) and pathologic proteinuria.\nCONCLUSION: Both cell-mediated and humoral effectors are capable of inducing renal injury in EAG. Given the similarity of the disease-initiating antigen in this model to the antigen in human anti-GBM glomerulonephritis, similar overlapping mechanisms are likely to operate in human disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/j.1523-1755.2005.67113.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2634600", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "67"
      }
    ], 
    "name": "Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antibody in injury", 
    "pagination": "566-575", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f45ce292c6843dc6138d9af27e5cc3b7205ee25dcea11801d2a820f49719bb15"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15673304"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1523-1755.2005.67113.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051298417"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1523-1755.2005.67113.x", 
      "https://app.dimensions.ai/details/publication/pub.1051298417"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v67/n2/full/4495079a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.67113.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.67113.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.67113.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.67113.x'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      88 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1523-1755.2005.67113.x schema:about N06a81719feed4fcca299d57f3f149cf4
2 N088368e0b3954e1aa1281c0726ab5e1d
3 N29da754cac1d44b6919e4e2c2e25886a
4 N41d52dacfb8e4811aed44ff013465feb
5 N52ec22becc9f4189907a6015152dc0b9
6 N6e6c6d9129a648189b3eb41ddd0d8e73
7 N798ec4177f4944768b14eb491f09881a
8 Na75b8719d9e743f29320ad64ef1da4ce
9 Na9784d285d344f1c92c7e5c1a3c0784b
10 Nf8c0bec13bb84aeebc9749ae58c23dd7
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author Nfe3a03c2110e44d0b891f26c12dd651d
14 schema:citation sg:pub.10.1038/350423a0
15 sg:pub.10.1038/ki.1986.238
16 sg:pub.10.1038/ki.1987.123
17 sg:pub.10.1038/ki.1989.228
18 sg:pub.10.1038/ki.1992.221
19 sg:pub.10.1038/ki.1996.163
20 sg:pub.10.1038/ki.1997.12
21 sg:pub.10.1038/ki.1997.97
22 sg:pub.10.1046/j.1523-1755.1999.00369.x
23 sg:pub.10.1046/j.1523-1755.2002.00312.x
24 sg:pub.10.1046/j.1523-1755.2003.00227.x
25 sg:pub.10.1046/j.1523-1755.2003.00241.x
26 https://app.dimensions.ai/details/publication/pub.1074869225
27 https://app.dimensions.ai/details/publication/pub.1074985310
28 https://app.dimensions.ai/details/publication/pub.1079720163
29 https://app.dimensions.ai/details/publication/pub.1080110209
30 https://app.dimensions.ai/details/publication/pub.1083115856
31 https://app.dimensions.ai/details/publication/pub.1083284945
32 https://doi.org/10.1002/(sici)1521-4141(199901)29:01<1::aid-immu1>3.0.co;2-r
33 https://doi.org/10.1002/path.1711580410
34 https://doi.org/10.1016/0003-2697(76)90527-3
35 https://doi.org/10.1016/0022-1759(83)90227-2
36 https://doi.org/10.1016/0092-8674(92)90030-g
37 https://doi.org/10.1016/s0140-6736(88)90413-8
38 https://doi.org/10.1046/j.1523-1755.2003.00227.x
39 https://doi.org/10.1046/j.1523-1755.2003.00241.x
40 https://doi.org/10.1056/nejmra022296
41 https://doi.org/10.1073/pnas.91.13.6201
42 https://doi.org/10.1074/jbc.272.27.17023
43 https://doi.org/10.1074/jbc.m207769200
44 https://doi.org/10.1074/jbc.m211951200
45 https://doi.org/10.1084/jem.126.6.989
46 https://doi.org/10.1084/jem.180.4.1295
47 https://doi.org/10.1084/jem.182.4.915
48 https://doi.org/10.1096/fj.02-0746com
49 https://doi.org/10.1097/01.asn.0000091588.80007.0e
50 https://doi.org/10.1097/01.asn.0000128968.27705.5e
51 https://doi.org/10.1101/gad.10.23.2981
52 https://doi.org/10.1111/j.1365-2249.1995.tb03663.x
53 https://doi.org/10.1126/science.279.5353.1052
54 https://doi.org/10.1152/ajprenal.1985.249.2.f241
55 https://doi.org/10.1172/jci111328
56 https://doi.org/10.1172/jci115319
57 https://doi.org/10.1172/jci119764
58 https://doi.org/10.1172/jci13876
59 https://doi.org/10.1172/jci15285
60 https://doi.org/10.1172/jci15918
61 https://doi.org/10.1172/jci4876
62 https://doi.org/10.7326/0003-4819-134-11-200106050-00009
63 schema:datePublished 2005-02
64 schema:datePublishedReg 2005-02-01
65 schema:description BACKGROUND: Goodpasture's disease [antiglomerular basement membrane (GBM) glomerulonephritis] is a classic autoimmune disease and the only organ-specific autoimmune renal disease in which the antigen is well described. The importance of antibodies against the non-collagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] is well established. However, observational human studies and studies in experimental systems also imply a role for cell-mediated effector injury. METHODS: Active experimental autoimmune glomerulonephritis (EAG) was induced by immunization with alpha3-alpha5(IV)NC1 heterodimers in B cell intact C57BL/6 mice and B cell (mu chain-deficient) mice. Passive disease was induced by transferring sera from B cell intact and B cell deficient mice with EAG to RAG-1-/- mice (that lack adaptive immunity). Histologic and functional injury was studied. RESULTS: Despite the absence of B cells and immunoglobulin in B-cell-deficient mice, histologic and functional injury developed in mice immunized with alpha3-alpha5(IV)NC1, with T cells and macrophages in glomeruli. Injury occurred to a similar degree to that found in B-cell-intact mice. Transfer of sera from B-cell-intact mice with EAG containing antibodies (but not from B-cell-deficient mice with EAG) to RAG-1-/- mice induced linear immunoglobulin deposits on the glomerular basement membrane (GBM) and pathologic proteinuria. CONCLUSION: Both cell-mediated and humoral effectors are capable of inducing renal injury in EAG. Given the similarity of the disease-initiating antigen in this model to the antigen in human anti-GBM glomerulonephritis, similar overlapping mechanisms are likely to operate in human disease.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf Na7c9af1a6e3b45c394969a1c0b842e91
70 Nf736f4b27c6d483ba6142f08799e693c
71 sg:journal.1015319
72 schema:name Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antibody in injury
73 schema:pagination 566-575
74 schema:productId N04c8ec8fef5847a5bac50c637a34df58
75 N0b7d4731e33240f1aa02415a88127d3d
76 N605acac19a0f44e49cd450035ec3f967
77 Na32493c58af9490d9960eb51ef5bed88
78 Na5b27c31dcdc46dcb710095576d9fc90
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051298417
80 https://doi.org/10.1111/j.1523-1755.2005.67113.x
81 schema:sdDatePublished 2019-04-10T16:29
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher Nb364bd0cb0a540b2a0958b3f77a38467
84 schema:url http://www.nature.com/ki/journal/v67/n2/full/4495079a.html
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N04c8ec8fef5847a5bac50c637a34df58 schema:name dimensions_id
89 schema:value pub.1051298417
90 rdf:type schema:PropertyValue
91 N06a81719feed4fcca299d57f3f149cf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Male
93 rdf:type schema:DefinedTerm
94 N0832a475a3f54671b03562f41d3f85b7 rdf:first sg:person.0623077762.94
95 rdf:rest Nd2e9260383574e8c959117a16d47b934
96 N088368e0b3954e1aa1281c0726ab5e1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name B-Lymphocytes
98 rdf:type schema:DefinedTerm
99 N0b7d4731e33240f1aa02415a88127d3d schema:name doi
100 schema:value 10.1111/j.1523-1755.2005.67113.x
101 rdf:type schema:PropertyValue
102 N0fe795e3d6ed486a98b6f14c720e1afd rdf:first sg:person.0700603677.38
103 rdf:rest rdf:nil
104 N1e11f36a7ed54fb18ecbfba06d5006b6 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
105 schema:familyName Dean
106 schema:givenName Elizabeth G
107 rdf:type schema:Person
108 N29da754cac1d44b6919e4e2c2e25886a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice
110 rdf:type schema:DefinedTerm
111 N41d52dacfb8e4811aed44ff013465feb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Animals
113 rdf:type schema:DefinedTerm
114 N45335fa3df9d473cb40748f72af2f4bd rdf:first sg:person.0613244032.33
115 rdf:rest Nd1d07ec4a67a4bac94b47fbbb3b2b179
116 N52ec22becc9f4189907a6015152dc0b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Antibodies
118 rdf:type schema:DefinedTerm
119 N605acac19a0f44e49cd450035ec3f967 schema:name pubmed_id
120 schema:value 15673304
121 rdf:type schema:PropertyValue
122 N6e6c6d9129a648189b3eb41ddd0d8e73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Autoantibodies
124 rdf:type schema:DefinedTerm
125 N798ec4177f4944768b14eb491f09881a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Proteinuria
127 rdf:type schema:DefinedTerm
128 N883baea751ac423ea91850a456559a4c rdf:first sg:person.01234647517.99
129 rdf:rest N45335fa3df9d473cb40748f72af2f4bd
130 Na32493c58af9490d9960eb51ef5bed88 schema:name readcube_id
131 schema:value f45ce292c6843dc6138d9af27e5cc3b7205ee25dcea11801d2a820f49719bb15
132 rdf:type schema:PropertyValue
133 Na5b27c31dcdc46dcb710095576d9fc90 schema:name nlm_unique_id
134 schema:value 0323470
135 rdf:type schema:PropertyValue
136 Na75b8719d9e743f29320ad64ef1da4ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Glomerulonephritis
138 rdf:type schema:DefinedTerm
139 Na7c9af1a6e3b45c394969a1c0b842e91 schema:volumeNumber 67
140 rdf:type schema:PublicationVolume
141 Na9784d285d344f1c92c7e5c1a3c0784b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Anti-Glomerular Basement Membrane Disease
143 rdf:type schema:DefinedTerm
144 Nb364bd0cb0a540b2a0958b3f77a38467 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 Nd1d07ec4a67a4bac94b47fbbb3b2b179 rdf:first sg:person.01233643032.17
147 rdf:rest Ne6fc20d21b8242c9a84e1ec054ce91e7
148 Nd2e9260383574e8c959117a16d47b934 rdf:first sg:person.01100567204.52
149 rdf:rest N883baea751ac423ea91850a456559a4c
150 Ne6fc20d21b8242c9a84e1ec054ce91e7 rdf:first sg:person.01131260677.45
151 rdf:rest N0fe795e3d6ed486a98b6f14c720e1afd
152 Nf736f4b27c6d483ba6142f08799e693c schema:issueNumber 2
153 rdf:type schema:PublicationIssue
154 Nf8c0bec13bb84aeebc9749ae58c23dd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice, Inbred C57BL
156 rdf:type schema:DefinedTerm
157 Nfe3a03c2110e44d0b891f26c12dd651d rdf:first N1e11f36a7ed54fb18ecbfba06d5006b6
158 rdf:rest N0832a475a3f54671b03562f41d3f85b7
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
163 schema:name Immunology
164 rdf:type schema:DefinedTerm
165 sg:grant.2634600 http://pending.schema.org/fundedItem sg:pub.10.1111/j.1523-1755.2005.67113.x
166 rdf:type schema:MonetaryGrant
167 sg:journal.1015319 schema:issn 0085-2538
168 1523-1755
169 schema:name Kidney International
170 rdf:type schema:Periodical
171 sg:person.01100567204.52 schema:familyName Li
172 schema:givenName Ming
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100567204.52
174 rdf:type schema:Person
175 sg:person.01131260677.45 schema:familyName Holdsworth
176 schema:givenName Stephen R
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45
178 rdf:type schema:Person
179 sg:person.01233643032.17 schema:familyName Hudson
180 schema:givenName Billy G
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233643032.17
182 rdf:type schema:Person
183 sg:person.01234647517.99 schema:familyName Edgtton
184 schema:givenName Kristy L
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234647517.99
186 rdf:type schema:Person
187 sg:person.0613244032.33 schema:familyName O'Sullivan
188 schema:givenName Kim M
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613244032.33
190 rdf:type schema:Person
191 sg:person.0623077762.94 schema:familyName Wilson
192 schema:givenName Gabrielle R A
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623077762.94
194 rdf:type schema:Person
195 sg:person.0700603677.38 schema:familyName Kitching
196 schema:givenName A Richard
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603677.38
198 rdf:type schema:Person
199 sg:pub.10.1038/350423a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018596250
200 https://doi.org/10.1038/350423a0
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/ki.1986.238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024809789
203 https://doi.org/10.1038/ki.1986.238
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/ki.1987.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025518790
206 https://doi.org/10.1038/ki.1987.123
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/ki.1989.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025839659
209 https://doi.org/10.1038/ki.1989.228
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/ki.1992.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029360728
212 https://doi.org/10.1038/ki.1992.221
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/ki.1996.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034811849
215 https://doi.org/10.1038/ki.1996.163
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/ki.1997.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022776985
218 https://doi.org/10.1038/ki.1997.12
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/ki.1997.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031598987
221 https://doi.org/10.1038/ki.1997.97
222 rdf:type schema:CreativeWork
223 sg:pub.10.1046/j.1523-1755.1999.00369.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049544773
224 https://doi.org/10.1046/j.1523-1755.1999.00369.x
225 rdf:type schema:CreativeWork
226 sg:pub.10.1046/j.1523-1755.2002.00312.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018318074
227 https://doi.org/10.1046/j.1523-1755.2002.00312.x
228 rdf:type schema:CreativeWork
229 sg:pub.10.1046/j.1523-1755.2003.00227.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017362991
230 https://doi.org/10.1046/j.1523-1755.2003.00227.x
231 rdf:type schema:CreativeWork
232 sg:pub.10.1046/j.1523-1755.2003.00241.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051214007
233 https://doi.org/10.1046/j.1523-1755.2003.00241.x
234 rdf:type schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1074869225 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1074985310 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1079720163 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1080110209 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1083115856 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1083284945 schema:CreativeWork
241 https://doi.org/10.1002/(sici)1521-4141(199901)29:01<1::aid-immu1>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1048215846
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/path.1711580410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039910951
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0022-1759(83)90227-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028048973
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0092-8674(92)90030-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1007090770
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0140-6736(88)90413-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045957451
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1046/j.1523-1755.2003.00227.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017362991
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1046/j.1523-1755.2003.00241.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051214007
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1056/nejmra022296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021861051
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1073/pnas.91.13.6201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003670619
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1074/jbc.272.27.17023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035206830
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1074/jbc.m207769200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014298291
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1074/jbc.m211951200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050447449
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1084/jem.126.6.989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000363832
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1084/jem.180.4.1295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036738268
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1084/jem.182.4.915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000094639
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1096/fj.02-0746com schema:sameAs https://app.dimensions.ai/details/publication/pub.1035604027
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/01.asn.0000091588.80007.0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319351
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/01.asn.0000128968.27705.5e schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319612
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1101/gad.10.23.2981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027630614
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1365-2249.1995.tb03663.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029948359
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1126/science.279.5353.1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559556
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1152/ajprenal.1985.249.2.f241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079587426
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1172/jci111328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017924244
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1172/jci115319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011137122
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1172/jci119764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036208764
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1172/jci13876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006600454
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1172/jci15285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415357
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1172/jci15918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415457
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1172/jci4876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041291912
300 rdf:type schema:CreativeWork
301 https://doi.org/10.7326/0003-4819-134-11-200106050-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073704554
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.416060.5 schema:alternateName Monash Medical Centre
304 schema:name Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...