Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-11

AUTHORS

Bernardo Rodríguez-Iturbe, Atilio Ferrebuz, Valentina Vanegas, Yasmir Quiroz, Fabiana Espinoza, Hector Pons, Nosratola D Vaziri

ABSTRACT

BACKGROUND: Chronic renal disease is associated with oxidative stress and reduced nitric oxide availability which, in turn, promotes hypertension and further progression of renal damage. Most actions of nitric oxide are mediated by cyclic 3',5' guanosine monophosphate (cGMP) which is rapidly degraded by phosphodiesterases (PDE). Therefore, we investigated if inhibition of PDE-5 would retard the progression of chronic renal failure. METHODS: We studied rats with 5/6 nephrectomy treated with sildenafil (2.5 mg/kg(-1)/day(-1)) in two experimental protocols. In the first protocol, we started sildenafil therapy immediately after renal ablation and continued treatment for 8 weeks. Control groups consisted of rats with renal ablation treated with drug-free vehicle and sham-operated rats with and without sildenafil treatment. RESULTS: In these studies, sildenafil treatment prevented hypertension and deterioration of renal function, reduced histologic damage, inflammation and apoptosis, delayed the onset of proteinuria, and preserved renal capillary integrity. In the second protocol we compared sildenafil with losartan (7.5 mg/kg(-1)/day(-1)) and the combination of both drugs in established renal disease, starting these drugs 4 weeks after 5/6 nephrectomy. Delayed sildenafil treatment failed to improve proteinuria and glomerulosclerosis but ameliorated hypertension and azotemia. CONCLUSION: These observations suggest that currently available PDE-5 inhibitors have potential clinical value in the treatment of chronic renal disease. More... »

PAGES

2131-2142

References to SciGraph publications

  • 2000-04. Lack of evidence of blood pressure-independent protection by renin-angiotensin system blockade after renal ablation in KIDNEY INTERNATIONAL
  • 1995-06. Oral administration of L-arginine and captopril in rats prevents chronic renal failure by nitric oxide production in KIDNEY INTERNATIONAL
  • 2001-05. Role of immunocompetent cells in nonimmune renal diseases in KIDNEY INTERNATIONAL
  • 2004-08. Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress in KIDNEY INTERNATIONAL
  • 1994-10. Radiotelemetric BP monitoring, antihypertensives and glomeruloprotection in remnant kidney model in KIDNEY INTERNATIONAL
  • 2004-11. Proteinuria predicting outcome in renal disease: Nondiabetic nephropathies (REIN) in KIDNEY INTERNATIONAL SUPPLEMENTS
  • 1984-08. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats in KIDNEY INTERNATIONAL
  • 2000-09. Total nitric oxide production is low in patients with chronic renal disease1 in KIDNEY INTERNATIONAL
  • 1996-01. Apoptosis in glomerular sclerosis in KIDNEY INTERNATIONAL
  • 2001-06. Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure in KIDNEY INTERNATIONAL
  • 2003-10. Apoptosis and NFκB activation are simultaneously induced in renal tubulointerstitium in experimental hypertension in KIDNEY INTERNATIONAL SUPPLEMENTS
  • 1997-07. Renal and systemic nitric oxide synthesis in rats with renal mass reduction in KIDNEY INTERNATIONAL
  • 1999-03. Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats in KIDNEY INTERNATIONAL
  • 2002-11. The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia in KIDNEY INTERNATIONAL
  • 2003-09. Combining lisinopril and L-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis in KIDNEY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.00669.x

    DOI

    http://dx.doi.org/10.1111/j.1523-1755.2005.00669.x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030263280

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16221212


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "3',5'-Cyclic-GMP Phosphodiesterases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Pressure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclic GMP", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclic Nucleotide Phosphodiesterases, Type 5", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glomerulosclerosis, Focal Segmental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Function Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphodiesterase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Piperazines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Purines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats, Sprague-Dawley", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Renal Insufficiency, Chronic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sildenafil Citrate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sulfones", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hospital Universitario de Maracaibo", 
              "id": "https://www.grid.ac/institutes/grid.411174.6", 
              "name": [
                "Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biom\u00e9dicas (INBIOMED) Maracaibo, Venezuela. bernardori@telcel.net.ve"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodr\u00edguez-Iturbe", 
            "givenName": "Bernardo", 
            "id": "sg:person.0111434245.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111434245.70"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Ferrebuz", 
            "givenName": "Atilio", 
            "id": "sg:person.0670650054.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670650054.45"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Vanegas", 
            "givenName": "Valentina", 
            "id": "sg:person.0714752437.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714752437.94"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Quiroz", 
            "givenName": "Yasmir", 
            "id": "sg:person.0622534654.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622534654.31"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Espinoza", 
            "givenName": "Fabiana", 
            "type": "Person"
          }, 
          {
            "familyName": "Pons", 
            "givenName": "Hector", 
            "id": "sg:person.01164103010.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164103010.22"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Vaziri", 
            "givenName": "Nosratola D", 
            "id": "sg:person.013067127357.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013067127357.48"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/clc.4960271306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000676571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/clc.4960271306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000676571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2002.00600.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000740650", 
              "https://doi.org/10.1046/j.1523-1755.2002.00600.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1755.2002.00600.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000740650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hc3601.096826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006571566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0046-8177(70)80061-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006830114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.3.1044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007878331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.86.9.960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010881895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041552-200401000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012205845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041552-200401000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012205845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1523-1755.2004.09221.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013616920", 
              "https://doi.org/10.1111/j.1523-1755.2004.09221.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1997.317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014161684", 
              "https://doi.org/10.1038/ki.1997.317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2002.tb04068.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016337321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2002.tb04068.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016337321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2000.00009.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016389519", 
              "https://doi.org/10.1046/j.1523-1755.2000.00009.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m404706200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019832866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1984.147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022500698", 
              "https://doi.org/10.1038/ki.1984.147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2001.00737.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023216863", 
              "https://doi.org/10.1046/j.1523-1755.2001.00737.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2004.06.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024613789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2000.00281.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027168012", 
              "https://doi.org/10.1046/j.1523-1755.2000.00281.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0272-6386(99)70229-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027655176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.64.s86.6.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028589968", 
              "https://doi.org/10.1046/j.1523-1755.64.s86.6.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1755.64.s86.6.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028589968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1996.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028958709", 
              "https://doi.org/10.1038/ki.1996.14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(92)90865-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029284704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(92)90865-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029284704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.00269.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031748216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0272-6386(12)80546-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035116022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041552-200501000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035943311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041552-200501000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035943311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(68)90589-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037040353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64175-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038143405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2003.00191.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039365124", 
              "https://doi.org/10.1046/j.1523-1755.2003.00191.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198209093071104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040743632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.1999.055003945.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041758722", 
              "https://doi.org/10.1046/j.1523-1755.1999.055003945.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000142051.36244.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046240201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.niox.2003.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046616638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2249.2003.02188.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047528794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2001.0590051626.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050069761", 
              "https://doi.org/10.1046/j.1523-1755.2001.0590051626.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1994.361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051734615", 
              "https://doi.org/10.1038/ki.1994.361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1523-1755.2004.00794.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052299111", 
              "https://doi.org/10.1111/j.1523-1755.2004.00794.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1995.214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052378648", 
              "https://doi.org/10.1038/ki.1995.214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/expphysiol.2004.028464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053124234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000139066.77892.04", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000139066.77892.04", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000139066.77892.04", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.asn.0000139066.77892.04", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060319716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00324.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063193800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.00199.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063197286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.0197.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063197874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-141-3-200408030-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073707553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074358467", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074490750", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074587497", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.2001.281.1.f38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074832740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074851629", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082233731", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.1998.274.4.f642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083256874"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-11", 
        "datePublishedReg": "2005-11-01", 
        "description": "BACKGROUND: Chronic renal disease is associated with oxidative stress and reduced nitric oxide availability which, in turn, promotes hypertension and further progression of renal damage. Most actions of nitric oxide are mediated by cyclic 3',5' guanosine monophosphate (cGMP) which is rapidly degraded by phosphodiesterases (PDE). Therefore, we investigated if inhibition of PDE-5 would retard the progression of chronic renal failure.\nMETHODS: We studied rats with 5/6 nephrectomy treated with sildenafil (2.5 mg/kg(-1)/day(-1)) in two experimental protocols. In the first protocol, we started sildenafil therapy immediately after renal ablation and continued treatment for 8 weeks. Control groups consisted of rats with renal ablation treated with drug-free vehicle and sham-operated rats with and without sildenafil treatment.\nRESULTS: In these studies, sildenafil treatment prevented hypertension and deterioration of renal function, reduced histologic damage, inflammation and apoptosis, delayed the onset of proteinuria, and preserved renal capillary integrity. In the second protocol we compared sildenafil with losartan (7.5 mg/kg(-1)/day(-1)) and the combination of both drugs in established renal disease, starting these drugs 4 weeks after 5/6 nephrectomy. Delayed sildenafil treatment failed to improve proteinuria and glomerulosclerosis but ameliorated hypertension and azotemia.\nCONCLUSION: These observations suggest that currently available PDE-5 inhibitors have potential clinical value in the treatment of chronic renal disease.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1111/j.1523-1755.2005.00669.x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1015319", 
            "issn": [
              "0085-2538", 
              "1523-1755"
            ], 
            "name": "Kidney International", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "68"
          }
        ], 
        "name": "Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage", 
        "pagination": "2131-2142", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "902b67ae2860272b64567287a2751f226240be9f933065969bf6c070322b0486"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16221212"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0323470"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1111/j.1523-1755.2005.00669.x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1030263280"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1111/j.1523-1755.2005.00669.x", 
          "https://app.dimensions.ai/details/publication/pub.1030263280"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:53", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000588.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ki/journal/v68/n5/full/4496357a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.00669.x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.00669.x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.00669.x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2005.00669.x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    332 TRIPLES      21 PREDICATES      96 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1111/j.1523-1755.2005.00669.x schema:about N0024b0d1cda84c89a8feecd6a50bdf37
    2 N023db3d3d6c14c34b749b001dbed0969
    3 N0d3b7b910be841889388443b28a352c6
    4 N370756e12e744cc387c6449066fc7877
    5 N446b5dcb06b64baa95e71a1054db4e04
    6 N44914ce6d28c4e199c6266991e5da1ed
    7 N7c85a787f8ae465cbac2b1e958e42934
    8 N8a0a70adc6ce4931a5805f0626bb7c07
    9 N93a9c6c3e8c6464a8dcbe65aa22391b2
    10 Nd434df62e6aa4e33aeb6505da2f5c2ca
    11 Ne081bc935c144c7180ee08671c02ed64
    12 Nead07b6dba5f450a997f9b4ae655a62e
    13 Nf0a664c811b048eeb4686ac1af3d38ed
    14 Nf62f7630cbbe4e999f38096181aceba1
    15 Nf8dd81e14b5c4560a2aad6b8457687c9
    16 Nf8f0335a08004566ad1ad95010261797
    17 Nff4be5aeec68474baff899ee83dae301
    18 anzsrc-for:11
    19 anzsrc-for:1103
    20 schema:author Nff759b484903494eb0d04315d85e83bc
    21 schema:citation sg:pub.10.1038/ki.1984.147
    22 sg:pub.10.1038/ki.1994.361
    23 sg:pub.10.1038/ki.1995.214
    24 sg:pub.10.1038/ki.1996.14
    25 sg:pub.10.1038/ki.1997.317
    26 sg:pub.10.1046/j.1523-1755.1999.055003945.x
    27 sg:pub.10.1046/j.1523-1755.2000.00009.x
    28 sg:pub.10.1046/j.1523-1755.2000.00281.x
    29 sg:pub.10.1046/j.1523-1755.2001.00737.x
    30 sg:pub.10.1046/j.1523-1755.2001.0590051626.x
    31 sg:pub.10.1046/j.1523-1755.2002.00600.x
    32 sg:pub.10.1046/j.1523-1755.2003.00191.x
    33 sg:pub.10.1046/j.1523-1755.64.s86.6.x
    34 sg:pub.10.1111/j.1523-1755.2004.00794.x
    35 sg:pub.10.1111/j.1523-1755.2004.09221.x
    36 https://app.dimensions.ai/details/publication/pub.1074358467
    37 https://app.dimensions.ai/details/publication/pub.1074490750
    38 https://app.dimensions.ai/details/publication/pub.1074587497
    39 https://app.dimensions.ai/details/publication/pub.1074851629
    40 https://app.dimensions.ai/details/publication/pub.1082233731
    41 https://doi.org/10.1002/clc.4960271306
    42 https://doi.org/10.1016/0140-6736(92)90865-z
    43 https://doi.org/10.1016/j.bbadis.2004.06.013
    44 https://doi.org/10.1016/j.niox.2003.12.002
    45 https://doi.org/10.1016/s0002-9440(10)64175-2
    46 https://doi.org/10.1016/s0046-8177(70)80061-2
    47 https://doi.org/10.1016/s0140-6736(68)90589-8
    48 https://doi.org/10.1016/s0272-6386(12)80546-4
    49 https://doi.org/10.1016/s0272-6386(99)70229-5
    50 https://doi.org/10.1046/j.1365-2249.2003.02188.x
    51 https://doi.org/10.1046/j.1523-1755.2002.00600.x
    52 https://doi.org/10.1046/j.1523-1755.64.s86.6.x
    53 https://doi.org/10.1056/nejm198209093071104
    54 https://doi.org/10.1073/pnas.91.3.1044
    55 https://doi.org/10.1074/jbc.m404706200
    56 https://doi.org/10.1097/00041552-200401000-00013
    57 https://doi.org/10.1097/00041552-200501000-00008
    58 https://doi.org/10.1097/01.asn.0000139066.77892.04
    59 https://doi.org/10.1111/j.1749-6632.2002.tb04068.x
    60 https://doi.org/10.1113/expphysiol.2004.028464
    61 https://doi.org/10.1152/ajpheart.00324.2002
    62 https://doi.org/10.1152/ajprenal.00199.2002
    63 https://doi.org/10.1152/ajprenal.00269.2003
    64 https://doi.org/10.1152/ajprenal.0197.2001
    65 https://doi.org/10.1152/ajprenal.1998.274.4.f642
    66 https://doi.org/10.1152/ajprenal.2001.281.1.f38
    67 https://doi.org/10.1161/01.cir.0000142051.36244.83
    68 https://doi.org/10.1161/01.res.86.9.960
    69 https://doi.org/10.1161/hc3601.096826
    70 https://doi.org/10.7326/0003-4819-141-3-200408030-00005
    71 schema:datePublished 2005-11
    72 schema:datePublishedReg 2005-11-01
    73 schema:description BACKGROUND: Chronic renal disease is associated with oxidative stress and reduced nitric oxide availability which, in turn, promotes hypertension and further progression of renal damage. Most actions of nitric oxide are mediated by cyclic 3',5' guanosine monophosphate (cGMP) which is rapidly degraded by phosphodiesterases (PDE). Therefore, we investigated if inhibition of PDE-5 would retard the progression of chronic renal failure. METHODS: We studied rats with 5/6 nephrectomy treated with sildenafil (2.5 mg/kg(-1)/day(-1)) in two experimental protocols. In the first protocol, we started sildenafil therapy immediately after renal ablation and continued treatment for 8 weeks. Control groups consisted of rats with renal ablation treated with drug-free vehicle and sham-operated rats with and without sildenafil treatment. RESULTS: In these studies, sildenafil treatment prevented hypertension and deterioration of renal function, reduced histologic damage, inflammation and apoptosis, delayed the onset of proteinuria, and preserved renal capillary integrity. In the second protocol we compared sildenafil with losartan (7.5 mg/kg(-1)/day(-1)) and the combination of both drugs in established renal disease, starting these drugs 4 weeks after 5/6 nephrectomy. Delayed sildenafil treatment failed to improve proteinuria and glomerulosclerosis but ameliorated hypertension and azotemia. CONCLUSION: These observations suggest that currently available PDE-5 inhibitors have potential clinical value in the treatment of chronic renal disease.
    74 schema:genre research_article
    75 schema:inLanguage en
    76 schema:isAccessibleForFree true
    77 schema:isPartOf N5cfe9f2aa0654218911af60044eae665
    78 N6067e0b4a066459487d10d4ead4cb3fb
    79 sg:journal.1015319
    80 schema:name Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage
    81 schema:pagination 2131-2142
    82 schema:productId N3a3605abc6f044b5b634e71516140a99
    83 N42320ae43b2c4ce58f454d00ed596b43
    84 N9fb16c9b4c874d5f9a92bb98e5492f40
    85 Nce1e8510d2824487b8fabb0c0b1da042
    86 Nfc48c3afc6684cafba7a3db5cfd1b4e0
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030263280
    88 https://doi.org/10.1111/j.1523-1755.2005.00669.x
    89 schema:sdDatePublished 2019-04-10T16:53
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher Ndf6dbccd35dc467ea385ec343d55f4a7
    92 schema:url http://www.nature.com/ki/journal/v68/n5/full/4496357a.html
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N0024b0d1cda84c89a8feecd6a50bdf37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Purines
    98 rdf:type schema:DefinedTerm
    99 N023db3d3d6c14c34b749b001dbed0969 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Cyclic Nucleotide Phosphodiesterases, Type 5
    101 rdf:type schema:DefinedTerm
    102 N03a58ece558c4002903db9ca6070b16c rdf:first sg:person.01164103010.22
    103 rdf:rest Ne9daff5a2b7048af8bd31ede7927651a
    104 N0d3b7b910be841889388443b28a352c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Sulfones
    106 rdf:type schema:DefinedTerm
    107 N220b252608854341b59dbc9bda4e00a0 rdf:first sg:person.0670650054.45
    108 rdf:rest N914bae52a91e431580d72d0af09cb1e7
    109 N221cbd0b5e07444798fffdbb5961ec73 rdf:first sg:person.0622534654.31
    110 rdf:rest N4c82e3fc116f4df591366e7860738a7a
    111 N370756e12e744cc387c6449066fc7877 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Renal Insufficiency, Chronic
    113 rdf:type schema:DefinedTerm
    114 N3a3605abc6f044b5b634e71516140a99 schema:name nlm_unique_id
    115 schema:value 0323470
    116 rdf:type schema:PropertyValue
    117 N42320ae43b2c4ce58f454d00ed596b43 schema:name dimensions_id
    118 schema:value pub.1030263280
    119 rdf:type schema:PropertyValue
    120 N446b5dcb06b64baa95e71a1054db4e04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Rats
    122 rdf:type schema:DefinedTerm
    123 N44914ce6d28c4e199c6266991e5da1ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Apoptosis
    125 rdf:type schema:DefinedTerm
    126 N4c82e3fc116f4df591366e7860738a7a rdf:first Nf7e5b16f77d84b5c9486484f5284cbcf
    127 rdf:rest N03a58ece558c4002903db9ca6070b16c
    128 N5cfe9f2aa0654218911af60044eae665 schema:issueNumber 5
    129 rdf:type schema:PublicationIssue
    130 N6067e0b4a066459487d10d4ead4cb3fb schema:volumeNumber 68
    131 rdf:type schema:PublicationVolume
    132 N7c85a787f8ae465cbac2b1e958e42934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Animals
    134 rdf:type schema:DefinedTerm
    135 N8a0a70adc6ce4931a5805f0626bb7c07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Blood Pressure
    137 rdf:type schema:DefinedTerm
    138 N914bae52a91e431580d72d0af09cb1e7 rdf:first sg:person.0714752437.94
    139 rdf:rest N221cbd0b5e07444798fffdbb5961ec73
    140 N93a9c6c3e8c6464a8dcbe65aa22391b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Kidney Function Tests
    142 rdf:type schema:DefinedTerm
    143 N9fb16c9b4c874d5f9a92bb98e5492f40 schema:name doi
    144 schema:value 10.1111/j.1523-1755.2005.00669.x
    145 rdf:type schema:PropertyValue
    146 Nce1e8510d2824487b8fabb0c0b1da042 schema:name readcube_id
    147 schema:value 902b67ae2860272b64567287a2751f226240be9f933065969bf6c070322b0486
    148 rdf:type schema:PropertyValue
    149 Nd434df62e6aa4e33aeb6505da2f5c2ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Rats, Sprague-Dawley
    151 rdf:type schema:DefinedTerm
    152 Ndf6dbccd35dc467ea385ec343d55f4a7 schema:name Springer Nature - SN SciGraph project
    153 rdf:type schema:Organization
    154 Ne081bc935c144c7180ee08671c02ed64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Phosphodiesterase Inhibitors
    156 rdf:type schema:DefinedTerm
    157 Ne9daff5a2b7048af8bd31ede7927651a rdf:first sg:person.013067127357.48
    158 rdf:rest rdf:nil
    159 Nead07b6dba5f450a997f9b4ae655a62e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name 3',5'-Cyclic-GMP Phosphodiesterases
    161 rdf:type schema:DefinedTerm
    162 Nf0a664c811b048eeb4686ac1af3d38ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Glomerulosclerosis, Focal Segmental
    164 rdf:type schema:DefinedTerm
    165 Nf62f7630cbbe4e999f38096181aceba1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Sildenafil Citrate
    167 rdf:type schema:DefinedTerm
    168 Nf7e5b16f77d84b5c9486484f5284cbcf schema:familyName Espinoza
    169 schema:givenName Fabiana
    170 rdf:type schema:Person
    171 Nf8dd81e14b5c4560a2aad6b8457687c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Male
    173 rdf:type schema:DefinedTerm
    174 Nf8f0335a08004566ad1ad95010261797 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Cyclic GMP
    176 rdf:type schema:DefinedTerm
    177 Nfc48c3afc6684cafba7a3db5cfd1b4e0 schema:name pubmed_id
    178 schema:value 16221212
    179 rdf:type schema:PropertyValue
    180 Nff4be5aeec68474baff899ee83dae301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Piperazines
    182 rdf:type schema:DefinedTerm
    183 Nff759b484903494eb0d04315d85e83bc rdf:first sg:person.0111434245.70
    184 rdf:rest N220b252608854341b59dbc9bda4e00a0
    185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    186 schema:name Medical and Health Sciences
    187 rdf:type schema:DefinedTerm
    188 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    189 schema:name Clinical Sciences
    190 rdf:type schema:DefinedTerm
    191 sg:journal.1015319 schema:issn 0085-2538
    192 1523-1755
    193 schema:name Kidney International
    194 rdf:type schema:Periodical
    195 sg:person.0111434245.70 schema:affiliation https://www.grid.ac/institutes/grid.411174.6
    196 schema:familyName Rodríguez-Iturbe
    197 schema:givenName Bernardo
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111434245.70
    199 rdf:type schema:Person
    200 sg:person.01164103010.22 schema:familyName Pons
    201 schema:givenName Hector
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164103010.22
    203 rdf:type schema:Person
    204 sg:person.013067127357.48 schema:familyName Vaziri
    205 schema:givenName Nosratola D
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013067127357.48
    207 rdf:type schema:Person
    208 sg:person.0622534654.31 schema:familyName Quiroz
    209 schema:givenName Yasmir
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622534654.31
    211 rdf:type schema:Person
    212 sg:person.0670650054.45 schema:familyName Ferrebuz
    213 schema:givenName Atilio
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670650054.45
    215 rdf:type schema:Person
    216 sg:person.0714752437.94 schema:familyName Vanegas
    217 schema:givenName Valentina
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714752437.94
    219 rdf:type schema:Person
    220 sg:pub.10.1038/ki.1984.147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022500698
    221 https://doi.org/10.1038/ki.1984.147
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/ki.1994.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051734615
    224 https://doi.org/10.1038/ki.1994.361
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/ki.1995.214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052378648
    227 https://doi.org/10.1038/ki.1995.214
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/ki.1996.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028958709
    230 https://doi.org/10.1038/ki.1996.14
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/ki.1997.317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014161684
    233 https://doi.org/10.1038/ki.1997.317
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1046/j.1523-1755.1999.055003945.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041758722
    236 https://doi.org/10.1046/j.1523-1755.1999.055003945.x
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1046/j.1523-1755.2000.00009.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016389519
    239 https://doi.org/10.1046/j.1523-1755.2000.00009.x
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1046/j.1523-1755.2000.00281.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027168012
    242 https://doi.org/10.1046/j.1523-1755.2000.00281.x
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1046/j.1523-1755.2001.00737.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023216863
    245 https://doi.org/10.1046/j.1523-1755.2001.00737.x
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1046/j.1523-1755.2001.0590051626.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050069761
    248 https://doi.org/10.1046/j.1523-1755.2001.0590051626.x
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1046/j.1523-1755.2002.00600.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000740650
    251 https://doi.org/10.1046/j.1523-1755.2002.00600.x
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1046/j.1523-1755.2003.00191.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039365124
    254 https://doi.org/10.1046/j.1523-1755.2003.00191.x
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1046/j.1523-1755.64.s86.6.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028589968
    257 https://doi.org/10.1046/j.1523-1755.64.s86.6.x
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1111/j.1523-1755.2004.00794.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052299111
    260 https://doi.org/10.1111/j.1523-1755.2004.00794.x
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1111/j.1523-1755.2004.09221.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013616920
    263 https://doi.org/10.1111/j.1523-1755.2004.09221.x
    264 rdf:type schema:CreativeWork
    265 https://app.dimensions.ai/details/publication/pub.1074358467 schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1074490750 schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1074587497 schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1074851629 schema:CreativeWork
    269 https://app.dimensions.ai/details/publication/pub.1082233731 schema:CreativeWork
    270 https://doi.org/10.1002/clc.4960271306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000676571
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/0140-6736(92)90865-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029284704
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.bbadis.2004.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024613789
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.niox.2003.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046616638
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/s0002-9440(10)64175-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038143405
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/s0046-8177(70)80061-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006830114
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/s0140-6736(68)90589-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037040353
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/s0272-6386(12)80546-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035116022
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/s0272-6386(99)70229-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027655176
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1046/j.1365-2249.2003.02188.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047528794
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1046/j.1523-1755.2002.00600.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000740650
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1046/j.1523-1755.64.s86.6.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028589968
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1056/nejm198209093071104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040743632
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1073/pnas.91.3.1044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007878331
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1074/jbc.m404706200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019832866
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1097/00041552-200401000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012205845
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1097/00041552-200501000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035943311
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1097/01.asn.0000139066.77892.04 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319716
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1111/j.1749-6632.2002.tb04068.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016337321
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1113/expphysiol.2004.028464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053124234
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1152/ajpheart.00324.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063193800
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1152/ajprenal.00199.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063197286
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1152/ajprenal.00269.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031748216
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1152/ajprenal.0197.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063197874
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1152/ajprenal.1998.274.4.f642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083256874
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1152/ajprenal.2001.281.1.f38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074832740
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1161/01.cir.0000142051.36244.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046240201
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1161/01.res.86.9.960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010881895
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1161/hc3601.096826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006571566
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.7326/0003-4819-141-3-200408030-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073707553
    329 rdf:type schema:CreativeWork
    330 https://www.grid.ac/institutes/grid.411174.6 schema:alternateName Hospital Universitario de Maracaibo
    331 schema:name Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomédicas (INBIOMED) Maracaibo, Venezuela. bernardori@telcel.net.ve
    332 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...