Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-07

AUTHORS

Daniel I Feig, Takahiko Nakagawa, S Ananth Karumanchi, William J Oliver, Duk-Hee Kang, Jennifer Finch, Richard J Johnson

ABSTRACT

BACKGROUND: Essential hypertension affects more than 25% of the world's population. Genetic, physiologic, and epidemiologic studies provide clues to its origins, but a clear understanding has been elusive. Recent experimental and clinical studies have implicated uric acid in the onset of essential hypertension. METHODS: In a retrospective chart review, we identified 95 children with confirmed, new onset hypertension, and evaluated the cause of hypertension and parental history of hypertension, birth weight, and serum uric acid. In an open-label, cross-over trial we treated 5 children with confirmed essential hypertension with allopurinol as single treatment agent, and screened for change in blood pressure by casual and ambulatory methods. In tissue culture experiments, we evaluated the effect of uric acid on glomerular endothelial cell function. RESULTS: Elevation of serum uric acid is related to the onset of essential hypertension in children, reduced birth weight, and endothelial dysfunction. Normalization of uric acid appears to ameliorate new onset essential hypertension. CONCLUSION: These findings, combined with animal model data, support the hypothesis that uric acid has a key role in the pathogenesis of early onset essential hypertension, and may unify some of the disparate theories of the origins of essential hypertension. More... »

PAGES

281-287

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00729.x

DOI

http://dx.doi.org/10.1111/j.1523-1755.2004.00729.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040976941

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15200435


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. dfeig@bcm.tmc.edu"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feig", 
        "givenName": "Daniel I", 
        "id": "sg:person.07673524004.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07673524004.34"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nakagawa", 
        "givenName": "Takahiko", 
        "id": "sg:person.011236241532.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011236241532.80"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Karumanchi", 
        "givenName": "S Ananth", 
        "id": "sg:person.01124076707.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124076707.96"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Oliver", 
        "givenName": "William J", 
        "id": "sg:person.0726735310.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726735310.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kang", 
        "givenName": "Duk-Hee", 
        "id": "sg:person.01361324372.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361324372.43"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Finch", 
        "givenName": "Jennifer", 
        "id": "sg:person.01144737276.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144737276.02"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Johnson", 
        "givenName": "Richard J", 
        "id": "sg:person.010175037017.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010175037017.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00041552-199305000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001054360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041552-199305000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001054360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001689006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000028589.66335.aa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002171159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-8703(87)90511-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005326652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa020549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007110529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.59.3.347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007428263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.298.6673.564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008085604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199212007-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008529671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199212007-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008529671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000072820.07472.3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014187001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.36.6.692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015123824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(01)01643-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015728924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1096-8652(200101)66:1<59::aid-ajh1011>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016397638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1600-6135.ajt10305.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1991.180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018553133", 
          "https://doi.org/10.1038/ki.1991.180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200104150-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018661102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200104150-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018661102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000066303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019742586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)13177-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020612848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)13177-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020612848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)65502-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023896345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199816030-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025454198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199816030-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025454198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.35.3.746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026423545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200209000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027474441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200209000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027474441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra011078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027772280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(76)93024-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028300937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-7435(88)90038-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029540974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(72)90050-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030397178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198310273091702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031582120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032205791", 
          "https://doi.org/10.1038/sj.jhh.1001049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032205791", 
          "https://doi.org/10.1038/sj.jhh.1001049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci17189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032940593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000091371.53502.d3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033476301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000091371.53502.d3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033476301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0910169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034853120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0910169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034853120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037118670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64175-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038143405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00016348409156277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039143801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)13722-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039444153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198209093071104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040743632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.1992.tb13726.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040902002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.1992.tb13726.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040902002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.34.1.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041121443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000085858.66548.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041224703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000085858.66548.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041224703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000181408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043195082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000017502.58595.ed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043211023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.crd.0000077361.00668.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049764580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-7061(02)03248-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050943793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hy1101.092839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051727272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2003.00018.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052123860", 
          "https://doi.org/10.1046/j.1523-1755.2003.00018.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1523-1755.2003.00018.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052123860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.132.3.401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054106311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.17.2235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054164154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/1.4.335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059381524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-199212000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060192808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199904000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060206661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199904000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060206661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005344-199904000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060206661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000034910.58454.fd", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060318945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5262.676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00170.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063197228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00283.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063197460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.2001.280.4.f727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074783825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074873581", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074944566", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076540805", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077996234", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078061197", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a115593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078694709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079833153", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a113972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080057171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082516600", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082901339", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-07", 
    "datePublishedReg": "2004-07-01", 
    "description": "BACKGROUND: Essential hypertension affects more than 25% of the world's population. Genetic, physiologic, and epidemiologic studies provide clues to its origins, but a clear understanding has been elusive. Recent experimental and clinical studies have implicated uric acid in the onset of essential hypertension.\nMETHODS: In a retrospective chart review, we identified 95 children with confirmed, new onset hypertension, and evaluated the cause of hypertension and parental history of hypertension, birth weight, and serum uric acid. In an open-label, cross-over trial we treated 5 children with confirmed essential hypertension with allopurinol as single treatment agent, and screened for change in blood pressure by casual and ambulatory methods. In tissue culture experiments, we evaluated the effect of uric acid on glomerular endothelial cell function.\nRESULTS: Elevation of serum uric acid is related to the onset of essential hypertension in children, reduced birth weight, and endothelial dysfunction. Normalization of uric acid appears to ameliorate new onset essential hypertension.\nCONCLUSION: These findings, combined with animal model data, support the hypothesis that uric acid has a key role in the pathogenesis of early onset essential hypertension, and may unify some of the disparate theories of the origins of essential hypertension.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/j.1523-1755.2004.00729.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440445", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2538262", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2418817", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "66"
      }
    ], 
    "name": "Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension", 
    "pagination": "281-287", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c3338d61f98989b8870a469738f5bbaecdd063a5161e09d4e17c36865fa4aa4e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15200435"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1523-1755.2004.00729.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040976941"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1523-1755.2004.00729.x", 
      "https://app.dimensions.ai/details/publication/pub.1040976941"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v66/n1/full/4494585a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00729.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00729.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00729.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00729.x'


 

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      21 PREDICATES      100 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1523-1755.2004.00729.x schema:about N1cc742a456e142a8962e46cd1df44627
2 N466ac59990df4d36b94e2c7441765d8d
3 N637bcf00880546c8a608c32edfc137dd
4 Nd0e6e18cbbf0451d89998a76a9f04e2c
5 Ndf3c7facd307484d80c69225f0b033bd
6 Nfd1d8bc426814862a52286dbf1fc67fa
7 anzsrc-for:11
8 anzsrc-for:1102
9 schema:author N5ed383f3a32849cb8f7f6d90a4931851
10 schema:citation sg:pub.10.1038/ki.1991.180
11 sg:pub.10.1038/sj.jhh.1001049
12 sg:pub.10.1046/j.1523-1755.2003.00018.x
13 https://app.dimensions.ai/details/publication/pub.1074873581
14 https://app.dimensions.ai/details/publication/pub.1074944566
15 https://app.dimensions.ai/details/publication/pub.1076540805
16 https://app.dimensions.ai/details/publication/pub.1077996234
17 https://app.dimensions.ai/details/publication/pub.1078061197
18 https://app.dimensions.ai/details/publication/pub.1079833153
19 https://app.dimensions.ai/details/publication/pub.1082516600
20 https://app.dimensions.ai/details/publication/pub.1082901339
21 https://doi.org/10.1001/archinte.132.3.401
22 https://doi.org/10.1001/jama.283.17.2235
23 https://doi.org/10.1002/1096-8652(200101)66:1<59::aid-ajh1011>3.0.co;2-z
24 https://doi.org/10.1016/0002-8703(87)90511-4
25 https://doi.org/10.1016/0002-9343(72)90050-2
26 https://doi.org/10.1016/0091-7435(88)90038-2
27 https://doi.org/10.1016/s0002-9440(10)64175-2
28 https://doi.org/10.1016/s0022-5347(05)65502-4
29 https://doi.org/10.1016/s0140-6736(03)13177-7
30 https://doi.org/10.1016/s0140-6736(03)13722-1
31 https://doi.org/10.1016/s0140-6736(76)93024-5
32 https://doi.org/10.1016/s0735-1097(01)01643-6
33 https://doi.org/10.1016/s0895-7061(02)03248-x
34 https://doi.org/10.1042/cs0910169
35 https://doi.org/10.1046/j.1523-1755.2003.00018.x
36 https://doi.org/10.1046/j.1600-6135.ajt10305.x
37 https://doi.org/10.1056/nejm198209093071104
38 https://doi.org/10.1056/nejm198310273091702
39 https://doi.org/10.1056/nejmoa020549
40 https://doi.org/10.1056/nejmra011078
41 https://doi.org/10.1084/jem.59.3.347
42 https://doi.org/10.1093/ajh/1.4.335
43 https://doi.org/10.1093/oxfordjournals.aje.a113972
44 https://doi.org/10.1093/oxfordjournals.aje.a115593
45 https://doi.org/10.1097/00004872-199212000-00004
46 https://doi.org/10.1097/00004872-199212007-00004
47 https://doi.org/10.1097/00004872-199816030-00003
48 https://doi.org/10.1097/00004872-200209000-00001
49 https://doi.org/10.1097/00005344-199904000-00020
50 https://doi.org/10.1097/00007890-200104150-00014
51 https://doi.org/10.1097/00041552-199305000-00001
52 https://doi.org/10.1097/01.asn.0000034910.58454.fd
53 https://doi.org/10.1097/01.crd.0000077361.00668.14
54 https://doi.org/10.1111/j.1471-0528.1992.tb13726.x
55 https://doi.org/10.1126/science.272.5262.676
56 https://doi.org/10.1136/bmj.298.6673.564
57 https://doi.org/10.1152/ajprenal.00170.2002
58 https://doi.org/10.1152/ajprenal.00283.2001
59 https://doi.org/10.1152/ajprenal.2001.280.4.f727
60 https://doi.org/10.1159/000066303
61 https://doi.org/10.1159/000181408
62 https://doi.org/10.1161/01.cir.0000017502.58595.ed
63 https://doi.org/10.1161/01.hyp.0000028589.66335.aa
64 https://doi.org/10.1161/01.hyp.0000072820.07472.3b
65 https://doi.org/10.1161/01.hyp.0000085858.66548.59
66 https://doi.org/10.1161/01.hyp.0000091371.53502.d3
67 https://doi.org/10.1161/01.hyp.34.1.151
68 https://doi.org/10.1161/01.hyp.35.3.746
69 https://doi.org/10.1161/01.res.36.6.692
70 https://doi.org/10.1161/hy1101.092839
71 https://doi.org/10.1172/jci119354
72 https://doi.org/10.1172/jci119416
73 https://doi.org/10.1172/jci17189
74 https://doi.org/10.3109/00016348409156277
75 schema:datePublished 2004-07
76 schema:datePublishedReg 2004-07-01
77 schema:description BACKGROUND: Essential hypertension affects more than 25% of the world's population. Genetic, physiologic, and epidemiologic studies provide clues to its origins, but a clear understanding has been elusive. Recent experimental and clinical studies have implicated uric acid in the onset of essential hypertension. METHODS: In a retrospective chart review, we identified 95 children with confirmed, new onset hypertension, and evaluated the cause of hypertension and parental history of hypertension, birth weight, and serum uric acid. In an open-label, cross-over trial we treated 5 children with confirmed essential hypertension with allopurinol as single treatment agent, and screened for change in blood pressure by casual and ambulatory methods. In tissue culture experiments, we evaluated the effect of uric acid on glomerular endothelial cell function. RESULTS: Elevation of serum uric acid is related to the onset of essential hypertension in children, reduced birth weight, and endothelial dysfunction. Normalization of uric acid appears to ameliorate new onset essential hypertension. CONCLUSION: These findings, combined with animal model data, support the hypothesis that uric acid has a key role in the pathogenesis of early onset essential hypertension, and may unify some of the disparate theories of the origins of essential hypertension.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf N72e96de31c994249bc7e336d343485b0
82 Nfb9af48aac744ea49239a50d2895a067
83 sg:journal.1015319
84 schema:name Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension
85 schema:pagination 281-287
86 schema:productId N0de0567b7f1d42248706260bee7dbd20
87 N5d0d5b3f64c74e2c9544c23c9d6c4f86
88 N6baf5f4f2e924affa59bb74a39a47188
89 Nbf355c15a8fa43819385468e39b92c1e
90 Nfd000783b84c4a2e9360741a435e4dd2
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040976941
92 https://doi.org/10.1111/j.1523-1755.2004.00729.x
93 schema:sdDatePublished 2019-04-10T23:12
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N76457efb1e7c497c9afe18c8e6e7da12
96 schema:url http://www.nature.com/ki/journal/v66/n1/full/4494585a.html
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0de0567b7f1d42248706260bee7dbd20 schema:name nlm_unique_id
101 schema:value 0323470
102 rdf:type schema:PropertyValue
103 N1cc742a456e142a8962e46cd1df44627 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N466ac59990df4d36b94e2c7441765d8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Nephrons
108 rdf:type schema:DefinedTerm
109 N5d0d5b3f64c74e2c9544c23c9d6c4f86 schema:name doi
110 schema:value 10.1111/j.1523-1755.2004.00729.x
111 rdf:type schema:PropertyValue
112 N5ed383f3a32849cb8f7f6d90a4931851 rdf:first sg:person.07673524004.34
113 rdf:rest N8be08c0548e34ac0a1770cb3a3a563ca
114 N6339c736867f47ca89056b0a6f229d9e rdf:first sg:person.010175037017.23
115 rdf:rest rdf:nil
116 N637bcf00880546c8a608c32edfc137dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Uric Acid
118 rdf:type schema:DefinedTerm
119 N6baf5f4f2e924affa59bb74a39a47188 schema:name readcube_id
120 schema:value c3338d61f98989b8870a469738f5bbaecdd063a5161e09d4e17c36865fa4aa4e
121 rdf:type schema:PropertyValue
122 N72e96de31c994249bc7e336d343485b0 schema:issueNumber 1
123 rdf:type schema:PublicationIssue
124 N76457efb1e7c497c9afe18c8e6e7da12 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N8be08c0548e34ac0a1770cb3a3a563ca rdf:first sg:person.011236241532.80
127 rdf:rest Ndcb2c2c9ed0e44a284a52a26b3b9ee37
128 Na61d81ca744a425aa1044999f4052e60 rdf:first sg:person.0726735310.21
129 rdf:rest Nfbc7d6ed3d474257a6bd51878460c6d1
130 Nbf355c15a8fa43819385468e39b92c1e schema:name dimensions_id
131 schema:value pub.1040976941
132 rdf:type schema:PropertyValue
133 Nc71cbd15a6fb4c63bcdc736820899dc0 rdf:first sg:person.01144737276.02
134 rdf:rest N6339c736867f47ca89056b0a6f229d9e
135 Nd0e6e18cbbf0451d89998a76a9f04e2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Hypertension
137 rdf:type schema:DefinedTerm
138 Ndcb2c2c9ed0e44a284a52a26b3b9ee37 rdf:first sg:person.01124076707.96
139 rdf:rest Na61d81ca744a425aa1044999f4052e60
140 Ndf3c7facd307484d80c69225f0b033bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Animals
142 rdf:type schema:DefinedTerm
143 Nfb9af48aac744ea49239a50d2895a067 schema:volumeNumber 66
144 rdf:type schema:PublicationVolume
145 Nfbc7d6ed3d474257a6bd51878460c6d1 rdf:first sg:person.01361324372.43
146 rdf:rest Nc71cbd15a6fb4c63bcdc736820899dc0
147 Nfd000783b84c4a2e9360741a435e4dd2 schema:name pubmed_id
148 schema:value 15200435
149 rdf:type schema:PropertyValue
150 Nfd1d8bc426814862a52286dbf1fc67fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Models, Biological
152 rdf:type schema:DefinedTerm
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
157 schema:name Cardiorespiratory Medicine and Haematology
158 rdf:type schema:DefinedTerm
159 sg:grant.2418817 http://pending.schema.org/fundedItem sg:pub.10.1111/j.1523-1755.2004.00729.x
160 rdf:type schema:MonetaryGrant
161 sg:grant.2440445 http://pending.schema.org/fundedItem sg:pub.10.1111/j.1523-1755.2004.00729.x
162 rdf:type schema:MonetaryGrant
163 sg:grant.2538262 http://pending.schema.org/fundedItem sg:pub.10.1111/j.1523-1755.2004.00729.x
164 rdf:type schema:MonetaryGrant
165 sg:journal.1015319 schema:issn 0085-2538
166 1523-1755
167 schema:name Kidney International
168 rdf:type schema:Periodical
169 sg:person.010175037017.23 schema:familyName Johnson
170 schema:givenName Richard J
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010175037017.23
172 rdf:type schema:Person
173 sg:person.011236241532.80 schema:familyName Nakagawa
174 schema:givenName Takahiko
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011236241532.80
176 rdf:type schema:Person
177 sg:person.01124076707.96 schema:familyName Karumanchi
178 schema:givenName S Ananth
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124076707.96
180 rdf:type schema:Person
181 sg:person.01144737276.02 schema:familyName Finch
182 schema:givenName Jennifer
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144737276.02
184 rdf:type schema:Person
185 sg:person.01361324372.43 schema:familyName Kang
186 schema:givenName Duk-Hee
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361324372.43
188 rdf:type schema:Person
189 sg:person.0726735310.21 schema:familyName Oliver
190 schema:givenName William J
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726735310.21
192 rdf:type schema:Person
193 sg:person.07673524004.34 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
194 schema:familyName Feig
195 schema:givenName Daniel I
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07673524004.34
197 rdf:type schema:Person
198 sg:pub.10.1038/ki.1991.180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018553133
199 https://doi.org/10.1038/ki.1991.180
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/sj.jhh.1001049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032205791
202 https://doi.org/10.1038/sj.jhh.1001049
203 rdf:type schema:CreativeWork
204 sg:pub.10.1046/j.1523-1755.2003.00018.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052123860
205 https://doi.org/10.1046/j.1523-1755.2003.00018.x
206 rdf:type schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1074873581 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1074944566 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1076540805 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1077996234 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1078061197 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1079833153 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1082516600 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082901339 schema:CreativeWork
215 https://doi.org/10.1001/archinte.132.3.401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054106311
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1001/jama.283.17.2235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054164154
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/1096-8652(200101)66:1<59::aid-ajh1011>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1016397638
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0002-8703(87)90511-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005326652
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0002-9343(72)90050-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030397178
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0091-7435(88)90038-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029540974
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0002-9440(10)64175-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038143405
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0022-5347(05)65502-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023896345
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0140-6736(03)13177-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020612848
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0140-6736(03)13722-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039444153
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0140-6736(76)93024-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028300937
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0735-1097(01)01643-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015728924
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0895-7061(02)03248-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050943793
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1042/cs0910169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034853120
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1046/j.1523-1755.2003.00018.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052123860
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1046/j.1600-6135.ajt10305.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017485359
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1056/nejm198209093071104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040743632
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1056/nejm198310273091702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031582120
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1056/nejmoa020549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007110529
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1056/nejmra011078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027772280
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1084/jem.59.3.347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007428263
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1093/ajh/1.4.335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059381524
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/oxfordjournals.aje.a113972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080057171
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/oxfordjournals.aje.a115593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078694709
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1097/00004872-199212000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060192808
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/00004872-199212007-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008529671
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/00004872-199816030-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025454198
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/00004872-200209000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027474441
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/00005344-199904000-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060206661
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00007890-200104150-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018661102
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/00041552-199305000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001054360
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/01.asn.0000034910.58454.fd schema:sameAs https://app.dimensions.ai/details/publication/pub.1060318945
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1097/01.crd.0000077361.00668.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049764580
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1471-0528.1992.tb13726.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040902002
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1126/science.272.5262.676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552898
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1136/bmj.298.6673.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008085604
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1152/ajprenal.00170.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063197228
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1152/ajprenal.00283.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063197460
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1152/ajprenal.2001.280.4.f727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074783825
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1159/000066303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019742586
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1159/000181408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043195082
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1161/01.cir.0000017502.58595.ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1043211023
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1161/01.hyp.0000028589.66335.aa schema:sameAs https://app.dimensions.ai/details/publication/pub.1002171159
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1161/01.hyp.0000072820.07472.3b schema:sameAs https://app.dimensions.ai/details/publication/pub.1014187001
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1161/01.hyp.0000085858.66548.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041224703
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1161/01.hyp.0000091371.53502.d3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033476301
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1161/01.hyp.34.1.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041121443
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1161/01.hyp.35.3.746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026423545
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1161/01.res.36.6.692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015123824
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1161/hy1101.092839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051727272
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1172/jci119354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037118670
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1172/jci119416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001689006
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1172/jci17189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032940593
320 rdf:type schema:CreativeWork
321 https://doi.org/10.3109/00016348409156277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039143801
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
324 schema:name Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. dfeig@bcm.tmc.edu
325 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...