Plasmin is not protective in experimental renal interstitial fibrosis1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-07

AUTHORS

Kristy L Edgtton, Renae M Gow, Darren J Kelly, Peter Carmeliet, A Richard Kitching

ABSTRACT

BACKGROUND: The plasminogen-plasmin system has potential beneficial or deleterious effects in the context of renal fibrosis. Recent studies have implicated plasminogen activators or their inhibitors in this process. METHODS: The development of renal interstitial fibrosis was studied in mice genetically deficient in plasminogen (plg-/- mice) and littermate controls (plg+/+ mice) by inducing unilateral ureteric obstruction (UUO) by ligating the left ureter. RESULTS: Collagen accumulation in the kidney was decreased in plg-/- mice at 21 days compared with plg+/+ mice by hydroxyproline assay (plg+/+ 19.0 +/- 1.2 microg collagen/mg tissue, plg-/- 15.6 +/- 0.5 microg collagen/mg tissue, P= 0.04). Macrophage accumulation in plg-/- mice was reduced at 21 days, consistent with a role for plasmin in macrophage recruitment in this model. Myofibroblast accumulation, assessed by the expression of alpha-smooth muscle actin (alpha-SMA), was similar in both groups at both time points. Endogenous plasmin played a role in the activation of transforming growth factor-beta (TGF-beta), as plg-/- mice had lower ratios of betaig-h3:TGF-beta1 mRNA than plg+/+ mice. Matrix metalloproteinase (MMP)-9 activity was unchanged in the absence of plasmin, but MMP-2 activity was decreased. CONCLUSION: Plasminogen, the key proenzyme in the plasminogen-plasmin system, does not protect mice from experimental interstitial fibrosis and may have significant pathogenetic effects. These findings, together with other recently published studies in the biology of renal fibrosis, imply that effects of proteins such as plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator receptor (uPAR) on renal fibrosis occur independently from the generation of plasmin. More... »

PAGES

68-76

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00707.x

DOI

http://dx.doi.org/10.1111/j.1523-1755.2004.00707.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003669658

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15200414


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Matrix Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrinolysin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocytes, Smooth Muscle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasminogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ureteral Obstruction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Edgtton", 
        "givenName": "Kristy L", 
        "id": "sg:person.01234647517.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234647517.99"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gow", 
        "givenName": "Renae M", 
        "id": "sg:person.01124627260.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124627260.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kelly", 
        "givenName": "Darren J", 
        "id": "sg:person.011174716202.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011174716202.88"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Carmeliet", 
        "givenName": "Peter", 
        "id": "sg:person.01033041553.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kitching", 
        "givenName": "A Richard", 
        "id": "sg:person.0700603677.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603677.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci119148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003641619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0420643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003955069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs0420643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003955069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.18.7.1035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004214594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.18.2440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004433216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006373571", 
          "https://doi.org/10.1038/ki.1994.246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63069-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010374527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod59.3.693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012159949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod59.3.693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012159949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0396-287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012515929", 
          "https://doi.org/10.1038/nm0396-287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017703347", 
          "https://doi.org/10.1038/ki.1997.188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199411103311907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019016349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.1998.00893.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020017103", 
          "https://doi.org/10.1111/j.1523-1755.1998.00893.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.98.23.2621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021730712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-5994.1980.tb03486.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023266962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0049-3848(98)00122-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027781685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)62533-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030662517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64529-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031342325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1993.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032543999", 
          "https://doi.org/10.1038/ki.1993.246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2001.030002587.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033454231", 
          "https://doi.org/10.1046/j.1523-1755.2001.030002587.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/18.1.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036396341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004670000461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036475691", 
          "https://doi.org/10.1007/s004670000461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.185.5.963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037349827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.3.777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037363532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2000.00360.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038125943", 
          "https://doi.org/10.1111/j.1523-1755.2000.00360.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.2002.00162.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040875356", 
          "https://doi.org/10.1046/j.1523-1755.2002.00162.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1995.150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045106811", 
          "https://doi.org/10.1038/ki.1995.150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/368419a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046408145", 
          "https://doi.org/10.1038/368419a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1998.00081.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049079130", 
          "https://doi.org/10.1046/j.1523-1755.1998.00081.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049635303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053487393", 
          "https://doi.org/10.1038/ki.1994.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac60205a053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055046820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000031804.77546.f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060318906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000064292.37793.fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000064292.37793.fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000064292.37793.fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000064701.70231.3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000064701.70231.3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000064701.70231.3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000064701.70231.3f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060319123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.0002.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063196988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.92.9.2585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063336749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci16219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063415493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci15045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1646463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077523677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1660098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080043651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080652311", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083222345", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-07", 
    "datePublishedReg": "2004-07-01", 
    "description": "BACKGROUND: The plasminogen-plasmin system has potential beneficial or deleterious effects in the context of renal fibrosis. Recent studies have implicated plasminogen activators or their inhibitors in this process.\nMETHODS: The development of renal interstitial fibrosis was studied in mice genetically deficient in plasminogen (plg-/- mice) and littermate controls (plg+/+ mice) by inducing unilateral ureteric obstruction (UUO) by ligating the left ureter.\nRESULTS: Collagen accumulation in the kidney was decreased in plg-/- mice at 21 days compared with plg+/+ mice by hydroxyproline assay (plg+/+ 19.0 +/- 1.2 microg collagen/mg tissue, plg-/- 15.6 +/- 0.5 microg collagen/mg tissue, P= 0.04). Macrophage accumulation in plg-/- mice was reduced at 21 days, consistent with a role for plasmin in macrophage recruitment in this model. Myofibroblast accumulation, assessed by the expression of alpha-smooth muscle actin (alpha-SMA), was similar in both groups at both time points. Endogenous plasmin played a role in the activation of transforming growth factor-beta (TGF-beta), as plg-/- mice had lower ratios of betaig-h3:TGF-beta1 mRNA than plg+/+ mice. Matrix metalloproteinase (MMP)-9 activity was unchanged in the absence of plasmin, but MMP-2 activity was decreased.\nCONCLUSION: Plasminogen, the key proenzyme in the plasminogen-plasmin system, does not protect mice from experimental interstitial fibrosis and may have significant pathogenetic effects. These findings, together with other recently published studies in the biology of renal fibrosis, imply that effects of proteins such as plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator receptor (uPAR) on renal fibrosis occur independently from the generation of plasmin.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/j.1523-1755.2004.00707.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "66"
      }
    ], 
    "name": "Plasmin is not protective in experimental renal interstitial fibrosis1", 
    "pagination": "68-76", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "117b132eb6fe3de4761b311f524be2da5ea33d9b6c123e0c9b6ab33da4ae865f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15200414"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1523-1755.2004.00707.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003669658"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1523-1755.2004.00707.x", 
      "https://app.dimensions.ai/details/publication/pub.1003669658"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v66/n1/full/4494564a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00707.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00707.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00707.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00707.x'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      89 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1523-1755.2004.00707.x schema:about N0328c48b256e4e21bf32cef040a0c241
2 N19d271e92e93453fa708110f8e1a7a50
3 N301604c2297e4166bc3ce628c25a6e11
4 N3e8a0f380cdf48ac8cdfb047c08167bb
5 N46ac6ec4013447afba3aeea9af773e2e
6 N51761aa4a573471b92eb9b8a049f3848
7 N5dbf155e4b2b455c838819d159957ba5
8 N7402c5cce50c4fd3985269737dcb8223
9 N80af5ac5b35749b9ad3f4c8e2a50aba5
10 N8a1a5f48ba334d728c50ceab8035d912
11 N994bde8c1a304f51877bdbfd7c045529
12 N9ea4d90f60434db3a3097d2c2aa2f854
13 Na1a990a42d1e4c168da90f40a9dd76b3
14 Na47a7a115ab7459d8e73ab499156b237
15 Nb8aa343c23804c6cb14d8e45ca15ba93
16 Nb8b198103c20422e8a288daa7f7cef4e
17 Nd13dca806b0e4ce6a0be86316677d042
18 Neffa0bb325fe4c129824cde8980fa04e
19 Nf0b898f297d644ddb6ab8fa4a86c3b2e
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N047428db15e54315905c2da1a84d2d07
23 schema:citation sg:pub.10.1007/s004670000461
24 sg:pub.10.1038/368419a0
25 sg:pub.10.1038/ki.1993.246
26 sg:pub.10.1038/ki.1994.245
27 sg:pub.10.1038/ki.1994.246
28 sg:pub.10.1038/ki.1995.150
29 sg:pub.10.1038/ki.1997.188
30 sg:pub.10.1038/nm0396-287
31 sg:pub.10.1046/j.1523-1755.1998.00081.x
32 sg:pub.10.1046/j.1523-1755.2001.030002587.x
33 sg:pub.10.1046/j.1523-1755.2002.00162.x
34 sg:pub.10.1111/j.1523-1755.1998.00893.x
35 sg:pub.10.1111/j.1523-1755.2000.00360.x
36 https://app.dimensions.ai/details/publication/pub.1080652311
37 https://app.dimensions.ai/details/publication/pub.1083222345
38 https://doi.org/10.1016/s0002-9440(10)62533-3
39 https://doi.org/10.1016/s0002-9440(10)63069-6
40 https://doi.org/10.1016/s0002-9440(10)64529-4
41 https://doi.org/10.1016/s0049-3848(98)00122-4
42 https://doi.org/10.1021/ac60205a053
43 https://doi.org/10.1042/cs0420643
44 https://doi.org/10.1055/s-0038-1646463
45 https://doi.org/10.1055/s-0038-1660098
46 https://doi.org/10.1056/nejm199411103311907
47 https://doi.org/10.1084/jem.185.5.963
48 https://doi.org/10.1093/ndt/18.1.178
49 https://doi.org/10.1095/biolreprod59.3.693
50 https://doi.org/10.1097/01.asn.0000031804.77546.f5
51 https://doi.org/10.1097/01.asn.0000064292.37793.fb
52 https://doi.org/10.1097/01.asn.0000064701.70231.3f
53 https://doi.org/10.1111/j.1445-5994.1980.tb03486.x
54 https://doi.org/10.1152/ajprenal.0002.2001
55 https://doi.org/10.1161/01.atv.18.7.1035
56 https://doi.org/10.1161/01.cir.92.9.2585
57 https://doi.org/10.1161/01.cir.98.23.2621
58 https://doi.org/10.1161/01.cir.99.18.2440
59 https://doi.org/10.1172/jci115104
60 https://doi.org/10.1172/jci119148
61 https://doi.org/10.1172/jci15045
62 https://doi.org/10.1172/jci16219
63 https://doi.org/10.1182/blood.v97.3.777
64 schema:datePublished 2004-07
65 schema:datePublishedReg 2004-07-01
66 schema:description BACKGROUND: The plasminogen-plasmin system has potential beneficial or deleterious effects in the context of renal fibrosis. Recent studies have implicated plasminogen activators or their inhibitors in this process. METHODS: The development of renal interstitial fibrosis was studied in mice genetically deficient in plasminogen (plg-/- mice) and littermate controls (plg+/+ mice) by inducing unilateral ureteric obstruction (UUO) by ligating the left ureter. RESULTS: Collagen accumulation in the kidney was decreased in plg-/- mice at 21 days compared with plg+/+ mice by hydroxyproline assay (plg+/+ 19.0 +/- 1.2 microg collagen/mg tissue, plg-/- 15.6 +/- 0.5 microg collagen/mg tissue, P= 0.04). Macrophage accumulation in plg-/- mice was reduced at 21 days, consistent with a role for plasmin in macrophage recruitment in this model. Myofibroblast accumulation, assessed by the expression of alpha-smooth muscle actin (alpha-SMA), was similar in both groups at both time points. Endogenous plasmin played a role in the activation of transforming growth factor-beta (TGF-beta), as plg-/- mice had lower ratios of betaig-h3:TGF-beta1 mRNA than plg+/+ mice. Matrix metalloproteinase (MMP)-9 activity was unchanged in the absence of plasmin, but MMP-2 activity was decreased. CONCLUSION: Plasminogen, the key proenzyme in the plasminogen-plasmin system, does not protect mice from experimental interstitial fibrosis and may have significant pathogenetic effects. These findings, together with other recently published studies in the biology of renal fibrosis, imply that effects of proteins such as plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator receptor (uPAR) on renal fibrosis occur independently from the generation of plasmin.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf Nafb474b444b54a78874c0d577badbe71
71 Ned7880dfafe94bebb0526b1c64ccf5fe
72 sg:journal.1015319
73 schema:name Plasmin is not protective in experimental renal interstitial fibrosis1
74 schema:pagination 68-76
75 schema:productId N2c6474c40120484693acd41a9f4b3a33
76 N52b55cbf171b46bea5760633b728fa61
77 N6197716af8cb4099b9b1e5d47e28935f
78 N8334323626924ad3b39726912e23f2e3
79 Nc4978369ff9145a1a73500e3cd55eb10
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003669658
81 https://doi.org/10.1111/j.1523-1755.2004.00707.x
82 schema:sdDatePublished 2019-04-10T19:44
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nad867fc9ec4044a9952d29917259bc4c
85 schema:url http://www.nature.com/ki/journal/v66/n1/full/4494564a.html
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0328c48b256e4e21bf32cef040a0c241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Animals
91 rdf:type schema:DefinedTerm
92 N047428db15e54315905c2da1a84d2d07 rdf:first sg:person.01234647517.99
93 rdf:rest N209612480b7d4dce9999c9fedc97c893
94 N19d271e92e93453fa708110f8e1a7a50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Collagen
96 rdf:type schema:DefinedTerm
97 N209612480b7d4dce9999c9fedc97c893 rdf:first sg:person.01124627260.12
98 rdf:rest N54ffc6945e7a41da9c83bf638b8f0758
99 N2bbbddf70baf419cb82938437ee3630c rdf:first sg:person.0700603677.38
100 rdf:rest rdf:nil
101 N2c6474c40120484693acd41a9f4b3a33 schema:name doi
102 schema:value 10.1111/j.1523-1755.2004.00707.x
103 rdf:type schema:PropertyValue
104 N301604c2297e4166bc3ce628c25a6e11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Transforming Growth Factor beta1
106 rdf:type schema:DefinedTerm
107 N398a31feb3b447f38eae2c225523635a rdf:first sg:person.01033041553.19
108 rdf:rest N2bbbddf70baf419cb82938437ee3630c
109 N3e8a0f380cdf48ac8cdfb047c08167bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Extracellular Matrix Proteins
111 rdf:type schema:DefinedTerm
112 N46ac6ec4013447afba3aeea9af773e2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Matrix Metalloproteinase 9
114 rdf:type schema:DefinedTerm
115 N51761aa4a573471b92eb9b8a049f3848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Plasminogen
117 rdf:type schema:DefinedTerm
118 N52b55cbf171b46bea5760633b728fa61 schema:name readcube_id
119 schema:value 117b132eb6fe3de4761b311f524be2da5ea33d9b6c123e0c9b6ab33da4ae865f
120 rdf:type schema:PropertyValue
121 N54ffc6945e7a41da9c83bf638b8f0758 rdf:first sg:person.011174716202.88
122 rdf:rest N398a31feb3b447f38eae2c225523635a
123 N5dbf155e4b2b455c838819d159957ba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mice
125 rdf:type schema:DefinedTerm
126 N6197716af8cb4099b9b1e5d47e28935f schema:name dimensions_id
127 schema:value pub.1003669658
128 rdf:type schema:PropertyValue
129 N7402c5cce50c4fd3985269737dcb8223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Kidney Diseases
131 rdf:type schema:DefinedTerm
132 N80af5ac5b35749b9ad3f4c8e2a50aba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Transforming Growth Factor beta
134 rdf:type schema:DefinedTerm
135 N8334323626924ad3b39726912e23f2e3 schema:name nlm_unique_id
136 schema:value 0323470
137 rdf:type schema:PropertyValue
138 N8a1a5f48ba334d728c50ceab8035d912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Macrophages
140 rdf:type schema:DefinedTerm
141 N994bde8c1a304f51877bdbfd7c045529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Fibrinolysin
143 rdf:type schema:DefinedTerm
144 N9ea4d90f60434db3a3097d2c2aa2f854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Fibroblasts
146 rdf:type schema:DefinedTerm
147 Na1a990a42d1e4c168da90f40a9dd76b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Matrix Metalloproteinase 2
149 rdf:type schema:DefinedTerm
150 Na47a7a115ab7459d8e73ab499156b237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Myocytes, Smooth Muscle
152 rdf:type schema:DefinedTerm
153 Nad867fc9ec4044a9952d29917259bc4c schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 Nafb474b444b54a78874c0d577badbe71 schema:volumeNumber 66
156 rdf:type schema:PublicationVolume
157 Nb8aa343c23804c6cb14d8e45ca15ba93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice, Knockout
159 rdf:type schema:DefinedTerm
160 Nb8b198103c20422e8a288daa7f7cef4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Fibrosis
162 rdf:type schema:DefinedTerm
163 Nc4978369ff9145a1a73500e3cd55eb10 schema:name pubmed_id
164 schema:value 15200414
165 rdf:type schema:PropertyValue
166 Nd13dca806b0e4ce6a0be86316677d042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name RNA, Messenger
168 rdf:type schema:DefinedTerm
169 Ned7880dfafe94bebb0526b1c64ccf5fe schema:issueNumber 1
170 rdf:type schema:PublicationIssue
171 Neffa0bb325fe4c129824cde8980fa04e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Ureteral Obstruction
173 rdf:type schema:DefinedTerm
174 Nf0b898f297d644ddb6ab8fa4a86c3b2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Mice, Inbred Strains
176 rdf:type schema:DefinedTerm
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
181 schema:name Clinical Sciences
182 rdf:type schema:DefinedTerm
183 sg:journal.1015319 schema:issn 0085-2538
184 1523-1755
185 schema:name Kidney International
186 rdf:type schema:Periodical
187 sg:person.01033041553.19 schema:familyName Carmeliet
188 schema:givenName Peter
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19
190 rdf:type schema:Person
191 sg:person.011174716202.88 schema:familyName Kelly
192 schema:givenName Darren J
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011174716202.88
194 rdf:type schema:Person
195 sg:person.01124627260.12 schema:familyName Gow
196 schema:givenName Renae M
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124627260.12
198 rdf:type schema:Person
199 sg:person.01234647517.99 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
200 schema:familyName Edgtton
201 schema:givenName Kristy L
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234647517.99
203 rdf:type schema:Person
204 sg:person.0700603677.38 schema:familyName Kitching
205 schema:givenName A Richard
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603677.38
207 rdf:type schema:Person
208 sg:pub.10.1007/s004670000461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036475691
209 https://doi.org/10.1007/s004670000461
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/368419a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046408145
212 https://doi.org/10.1038/368419a0
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/ki.1993.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032543999
215 https://doi.org/10.1038/ki.1993.246
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/ki.1994.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487393
218 https://doi.org/10.1038/ki.1994.245
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/ki.1994.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006373571
221 https://doi.org/10.1038/ki.1994.246
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/ki.1995.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045106811
224 https://doi.org/10.1038/ki.1995.150
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/ki.1997.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017703347
227 https://doi.org/10.1038/ki.1997.188
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/nm0396-287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012515929
230 https://doi.org/10.1038/nm0396-287
231 rdf:type schema:CreativeWork
232 sg:pub.10.1046/j.1523-1755.1998.00081.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049079130
233 https://doi.org/10.1046/j.1523-1755.1998.00081.x
234 rdf:type schema:CreativeWork
235 sg:pub.10.1046/j.1523-1755.2001.030002587.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033454231
236 https://doi.org/10.1046/j.1523-1755.2001.030002587.x
237 rdf:type schema:CreativeWork
238 sg:pub.10.1046/j.1523-1755.2002.00162.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040875356
239 https://doi.org/10.1046/j.1523-1755.2002.00162.x
240 rdf:type schema:CreativeWork
241 sg:pub.10.1111/j.1523-1755.1998.00893.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020017103
242 https://doi.org/10.1111/j.1523-1755.1998.00893.x
243 rdf:type schema:CreativeWork
244 sg:pub.10.1111/j.1523-1755.2000.00360.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038125943
245 https://doi.org/10.1111/j.1523-1755.2000.00360.x
246 rdf:type schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1080652311 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1083222345 schema:CreativeWork
249 https://doi.org/10.1016/s0002-9440(10)62533-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030662517
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0002-9440(10)63069-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010374527
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0002-9440(10)64529-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031342325
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0049-3848(98)00122-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027781685
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1021/ac60205a053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055046820
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1042/cs0420643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003955069
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1055/s-0038-1646463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077523677
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1055/s-0038-1660098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080043651
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1056/nejm199411103311907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019016349
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1084/jem.185.5.963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037349827
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/ndt/18.1.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036396341
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1095/biolreprod59.3.693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012159949
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/01.asn.0000031804.77546.f5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060318906
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/01.asn.0000064292.37793.fb schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319120
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/01.asn.0000064701.70231.3f schema:sameAs https://app.dimensions.ai/details/publication/pub.1060319123
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/j.1445-5994.1980.tb03486.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023266962
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1152/ajprenal.0002.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063196988
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1161/01.atv.18.7.1035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004214594
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1161/01.cir.92.9.2585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063336749
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1161/01.cir.98.23.2621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021730712
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1161/01.cir.99.18.2440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004433216
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1172/jci115104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049635303
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1172/jci119148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003641619
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1172/jci15045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416170
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1172/jci16219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415493
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1182/blood.v97.3.777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037363532
300 rdf:type schema:CreativeWork
301 https://www.grid.ac/institutes/grid.416060.5 schema:alternateName Monash Medical Centre
302 schema:name Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...