Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-05

AUTHORS

Maya R Vilà, Gerardo G Kaplan, Dino Feigelstock, Margarita Nadal, Joan Morote, Ruth Porta, Joaquim Bellmunt, Anna Meseguer

ABSTRACT

BACKGROUND: The molecular mechanisms underlying tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC) are not well understood. We aimed to identify new molecular markers to provide insight into these processes. METHODS: This work reports on the identification of human hepatitis A virus cellular receptor 1 (hHAVcr-1) as a differentially expressed gene in ccRCC using RNA-based arbitrarily primed polymerase chain reaction (RAP-PCR). Results were further confirmed by Northern and Western blot assays. Carcinoma 769-P and normal HK-2 cells derived from proximal tubule epithelial cells, grown under different culture conditions, were used to understand the putative role of hHAVcr-1 in renal malignancy. hHAVcr-1 stable transfected clones and dipeptidyl peptidase IV (DPPIV) assays allowed assessing its involvement in cell differentiation. RESULTS: The hHAVcr-1 is overexpressed in eight out of 13 ccRCC and its expression neglected in benign oncocytomas. In culture, hhavcr-1 is dramatically overexpressed in normal and tumor cell lines that, having acquired the fully differentiated phenotype, are induced to de-differentiate by means of phorbol ester phorbol 12-myristate-13-acetate (PMA) treatment. Similarly, differentiation prevention by addition of PMA to confluent cells also increases hhavcr-1 expression. hHAVcr-1 stable transfected 769-P cells proved that hhavcr-1 itself blocks differentiation. Since hhavcr-1 is expressed at higher levels in tumor cells, we used an African green monkey cell model to show that immunotoxins directed against the monkey homologue of hhavcr-1 could kill kidney cells. CONCLUSION: Our results showed that hHAVcr-1 blocks differentiation of proximal tubule epithelial cells and that it could be used as a target for therapy of kidney carcinomas. More... »

PAGES

1761-1773

Identifiers

URI

http://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00601.x

DOI

http://dx.doi.org/10.1111/j.1523-1755.2004.00601.x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017166225

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15086915


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis A Virus Cellular Receptor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis A virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Virus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Universitari Vall d'Hebron", 
          "id": "https://www.grid.ac/institutes/grid.411083.f", 
          "name": [
            "Centre d'Investigacions en Bioqu\u00edmica i Biologia Molecular (CIBBIM), Hospital Universitari Vall d'Hebron, Barcelona. Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vil\u00e0", 
        "givenName": "Maya R", 
        "id": "sg:person.013207107432.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013207107432.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kaplan", 
        "givenName": "Gerardo G", 
        "id": "sg:person.01001563417.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001563417.79"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Feigelstock", 
        "givenName": "Dino", 
        "id": "sg:person.0770473436.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770473436.67"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nadal", 
        "givenName": "Margarita", 
        "id": "sg:person.01112263622.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112263622.40"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Morote", 
        "givenName": "Joan", 
        "id": "sg:person.07713025034.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07713025034.84"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Porta", 
        "givenName": "Ruth", 
        "type": "Person"
      }, 
      {
        "familyName": "Bellmunt", 
        "givenName": "Joaquim", 
        "id": "sg:person.01174264563.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174264563.01"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Meseguer", 
        "givenName": "Anna", 
        "id": "sg:person.01177377426.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177377426.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1046/j.1523-1755.2002.00433.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005473484", 
          "https://doi.org/10.1046/j.1523-1755.2002.00433.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-4608(86)90066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006140152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.171209998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006597771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007964460", 
          "https://doi.org/10.1038/nrc779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007964460", 
          "https://doi.org/10.1038/nrc779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19980504)76:3<337::aid-ijc9>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008165728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.129.1.255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008578038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-5002(89)90356-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009394364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)67892-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011414145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(87)90021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013321498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042307-200109000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013637842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042307-200109000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013637842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042307-200109000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013637842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(95)54020-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014409014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00451467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016698310", 
          "https://doi.org/10.1007/bf00451467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00451467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016698310", 
          "https://doi.org/10.1007/bf00451467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20000701)89:1<152::aid-cncr20>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022056299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.18.1.576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026625324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200562200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026976729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.10.5400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031332428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040568109", 
          "https://doi.org/10.1038/ni739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040568109", 
          "https://doi.org/10.1038/ni739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/20.19.4965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040951474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001200050311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041092433", 
          "https://doi.org/10.1007/s001200050311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65349-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042585483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044350397", 
          "https://doi.org/10.1038/ki.1994.6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.7.4135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044428091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000056987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048480256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.111.5.2097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049618726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.34.1.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051066833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1987.9999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054484911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064243691", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.139.2.5763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064282179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074814434", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078472116", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079236979", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079410921", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)48932-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079428168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079698281", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424614", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424621", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082711213", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082737210", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082787100", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082842695", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082958854", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00803.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082979352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083288885", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-05", 
    "datePublishedReg": "2004-05-01", 
    "description": "BACKGROUND: The molecular mechanisms underlying tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC) are not well understood. We aimed to identify new molecular markers to provide insight into these processes.\nMETHODS: This work reports on the identification of human hepatitis A virus cellular receptor 1 (hHAVcr-1) as a differentially expressed gene in ccRCC using RNA-based arbitrarily primed polymerase chain reaction (RAP-PCR). Results were further confirmed by Northern and Western blot assays. Carcinoma 769-P and normal HK-2 cells derived from proximal tubule epithelial cells, grown under different culture conditions, were used to understand the putative role of hHAVcr-1 in renal malignancy. hHAVcr-1 stable transfected clones and dipeptidyl peptidase IV (DPPIV) assays allowed assessing its involvement in cell differentiation.\nRESULTS: The hHAVcr-1 is overexpressed in eight out of 13 ccRCC and its expression neglected in benign oncocytomas. In culture, hhavcr-1 is dramatically overexpressed in normal and tumor cell lines that, having acquired the fully differentiated phenotype, are induced to de-differentiate by means of phorbol ester phorbol 12-myristate-13-acetate (PMA) treatment. Similarly, differentiation prevention by addition of PMA to confluent cells also increases hhavcr-1 expression. hHAVcr-1 stable transfected 769-P cells proved that hhavcr-1 itself blocks differentiation. Since hhavcr-1 is expressed at higher levels in tumor cells, we used an African green monkey cell model to show that immunotoxins directed against the monkey homologue of hhavcr-1 could kill kidney cells.\nCONCLUSION: Our results showed that hHAVcr-1 blocks differentiation of proximal tubule epithelial cells and that it could be used as a target for therapy of kidney carcinomas.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1111/j.1523-1755.2004.00601.x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "65"
      }
    ], 
    "name": "Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma", 
    "pagination": "1761-1773", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "51c964cc195a36e5589c06f12c01f2227cace7b2d474ec9eeb4fd26fa8947ced"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15086915"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1111/j.1523-1755.2004.00601.x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017166225"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1111/j.1523-1755.2004.00601.x", 
      "https://app.dimensions.ai/details/publication/pub.1017166225"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v65/n5/full/4494463a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00601.x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00601.x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00601.x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1111/j.1523-1755.2004.00601.x'


 

This table displays all metadata directly associated to this object as RDF triples.

339 TRIPLES      21 PREDICATES      99 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1111/j.1523-1755.2004.00601.x schema:about N0303b95682d145a7920493d222e31636
2 N0917c99227854262b49e35b8009895ac
3 N142c19b8fe424a03ac46018d418ce643
4 N1938d501da404cd789a56ba4f1bfc9f6
5 N4ced64efc0354cd4b5860bbf2362fc74
6 N4f89d0e547fa4d6baecdaf11a74a125f
7 N595b0cd6c18d479091832e1d75442d2e
8 N6c8f691a61a2498aaa5d3e5aebce1837
9 N7016d835fa124626bb066d52523fead0
10 N79aeaa46148e43a5ade0cc0b2daf3874
11 N804957469a564b64b4c968db5ca36341
12 N846b8bb9f6394ba1afd1352541aca8f6
13 N8fddece2abd147c89d278c69897b5930
14 Na2cc54f9f6c243619a415efca33540af
15 Na7a6cd4d6967482386019ce9c545c87e
16 Nb36a2a18d43b44bca2af1774702f0435
17 Nb448240867694fcba9939cec1b00e59d
18 Nb7fb76c7e06941bcbacc0136a7fb1fa8
19 Nbaac2e285305484c88d14fee7a0d757b
20 Ncf51de041d3b4ca58bcc6945f0281037
21 Nd84ba915913843f6b8432d4903fa28d2
22 Ndad0b32625aa4bee95bf3bc593e00217
23 Nde5ead5f5e134a7f92d3327c1283fe15
24 Ne9f9961f7d4f45028fbef5e3181dce8e
25 Nebe4397475ad4ef9a7daa0d2020472a9
26 Nf0b6a3651c8a4a39a6fe5cf49a17e97a
27 Nf474a0496450434abc4a2748e35d8626
28 anzsrc-for:11
29 anzsrc-for:1103
30 schema:author N08db46881fad4cf3983ac1be89ef94e7
31 schema:citation sg:pub.10.1007/bf00451467
32 sg:pub.10.1007/s001200050311
33 sg:pub.10.1038/ki.1994.6
34 sg:pub.10.1038/ni739
35 sg:pub.10.1038/nrc779
36 sg:pub.10.1046/j.1523-1755.2002.00433.x
37 https://app.dimensions.ai/details/publication/pub.1064243691
38 https://app.dimensions.ai/details/publication/pub.1074814434
39 https://app.dimensions.ai/details/publication/pub.1078472116
40 https://app.dimensions.ai/details/publication/pub.1079236979
41 https://app.dimensions.ai/details/publication/pub.1079410921
42 https://app.dimensions.ai/details/publication/pub.1079698281
43 https://app.dimensions.ai/details/publication/pub.1082424614
44 https://app.dimensions.ai/details/publication/pub.1082424621
45 https://app.dimensions.ai/details/publication/pub.1082711213
46 https://app.dimensions.ai/details/publication/pub.1082737210
47 https://app.dimensions.ai/details/publication/pub.1082787100
48 https://app.dimensions.ai/details/publication/pub.1082842695
49 https://app.dimensions.ai/details/publication/pub.1082958854
50 https://app.dimensions.ai/details/publication/pub.1083288885
51 https://doi.org/10.1002/(sici)1097-0215(19980504)76:3<337::aid-ijc9>3.0.co;2-w
52 https://doi.org/10.1002/1097-0142(20000701)89:1<152::aid-cncr20>3.0.co;2-t
53 https://doi.org/10.1002/j.1460-2075.1996.tb00803.x
54 https://doi.org/10.1006/abio.1987.9999
55 https://doi.org/10.1016/0003-2697(87)90021-2
56 https://doi.org/10.1016/0076-6879(95)54020-2
57 https://doi.org/10.1016/0165-4608(86)90066-x
58 https://doi.org/10.1016/0169-5002(89)90356-5
59 https://doi.org/10.1016/s0002-9440(10)65349-7
60 https://doi.org/10.1016/s0022-5347(05)67892-5
61 https://doi.org/10.1016/s0022-5347(17)48932-4
62 https://doi.org/10.1073/pnas.171209998
63 https://doi.org/10.1073/pnas.96.10.5400
64 https://doi.org/10.1074/jbc.273.7.4135
65 https://doi.org/10.1074/jbc.m200562200
66 https://doi.org/10.1083/jcb.111.5.2097
67 https://doi.org/10.1083/jcb.129.1.255
68 https://doi.org/10.1093/nar/20.19.4965
69 https://doi.org/10.1097/00042307-200109000-00003
70 https://doi.org/10.1128/mcb.18.1.576
71 https://doi.org/10.1136/jmg.34.1.50
72 https://doi.org/10.1159/000056987
73 https://doi.org/10.1210/endo.139.2.5763
74 schema:datePublished 2004-05
75 schema:datePublishedReg 2004-05-01
76 schema:description BACKGROUND: The molecular mechanisms underlying tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC) are not well understood. We aimed to identify new molecular markers to provide insight into these processes. METHODS: This work reports on the identification of human hepatitis A virus cellular receptor 1 (hHAVcr-1) as a differentially expressed gene in ccRCC using RNA-based arbitrarily primed polymerase chain reaction (RAP-PCR). Results were further confirmed by Northern and Western blot assays. Carcinoma 769-P and normal HK-2 cells derived from proximal tubule epithelial cells, grown under different culture conditions, were used to understand the putative role of hHAVcr-1 in renal malignancy. hHAVcr-1 stable transfected clones and dipeptidyl peptidase IV (DPPIV) assays allowed assessing its involvement in cell differentiation. RESULTS: The hHAVcr-1 is overexpressed in eight out of 13 ccRCC and its expression neglected in benign oncocytomas. In culture, hhavcr-1 is dramatically overexpressed in normal and tumor cell lines that, having acquired the fully differentiated phenotype, are induced to de-differentiate by means of phorbol ester phorbol 12-myristate-13-acetate (PMA) treatment. Similarly, differentiation prevention by addition of PMA to confluent cells also increases hhavcr-1 expression. hHAVcr-1 stable transfected 769-P cells proved that hhavcr-1 itself blocks differentiation. Since hhavcr-1 is expressed at higher levels in tumor cells, we used an African green monkey cell model to show that immunotoxins directed against the monkey homologue of hhavcr-1 could kill kidney cells. CONCLUSION: Our results showed that hHAVcr-1 blocks differentiation of proximal tubule epithelial cells and that it could be used as a target for therapy of kidney carcinomas.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N6fc848a859054c0188efed7f64a40aa4
81 N8133b5d869bf40e69ad8ab71df388558
82 sg:journal.1015319
83 schema:name Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma
84 schema:pagination 1761-1773
85 schema:productId N36f3b2c087a14a939f6fb8d846ed26f8
86 N549da3ecb08a4023bff88f779bbcb4e7
87 N8227f20324344afa8575eb879ec524c2
88 N986b464cec4b4d758fda526d3f12e52d
89 Nd7e0d63280c9435cbbafad97319be517
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017166225
91 https://doi.org/10.1111/j.1523-1755.2004.00601.x
92 schema:sdDatePublished 2019-04-10T20:34
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N210f7d7a3661433e851cb109e3ead8e0
95 schema:url http://www.nature.com/ki/journal/v65/n5/full/4494463a.html
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N0303b95682d145a7920493d222e31636 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Base Sequence
101 rdf:type schema:DefinedTerm
102 N08db46881fad4cf3983ac1be89ef94e7 rdf:first sg:person.013207107432.21
103 rdf:rest N624511dc561f4649b2b945ab44ce848d
104 N0917c99227854262b49e35b8009895ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Aged, 80 and over
106 rdf:type schema:DefinedTerm
107 N142c19b8fe424a03ac46018d418ce643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aged
109 rdf:type schema:DefinedTerm
110 N1938d501da404cd789a56ba4f1bfc9f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name In Situ Hybridization, Fluorescence
112 rdf:type schema:DefinedTerm
113 N210f7d7a3661433e851cb109e3ead8e0 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 N36f3b2c087a14a939f6fb8d846ed26f8 schema:name readcube_id
116 schema:value 51c964cc195a36e5589c06f12c01f2227cace7b2d474ec9eeb4fd26fa8947ced
117 rdf:type schema:PropertyValue
118 N4ced64efc0354cd4b5860bbf2362fc74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Adult
120 rdf:type schema:DefinedTerm
121 N4f89d0e547fa4d6baecdaf11a74a125f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Animals
123 rdf:type schema:DefinedTerm
124 N549da3ecb08a4023bff88f779bbcb4e7 schema:name doi
125 schema:value 10.1111/j.1523-1755.2004.00601.x
126 rdf:type schema:PropertyValue
127 N595b0cd6c18d479091832e1d75442d2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Hepatitis A virus
129 rdf:type schema:DefinedTerm
130 N61bdffe19b634e23aa73724e368999bb rdf:first sg:person.01174264563.01
131 rdf:rest Nc7bfed36c6994a3a8566dac9c9a06cf2
132 N624511dc561f4649b2b945ab44ce848d rdf:first sg:person.01001563417.79
133 rdf:rest Nf9595ca9cda4406e968b0ccf6836f84f
134 N6c8f691a61a2498aaa5d3e5aebce1837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name RNA, Messenger
136 rdf:type schema:DefinedTerm
137 N6fc848a859054c0188efed7f64a40aa4 schema:volumeNumber 65
138 rdf:type schema:PublicationVolume
139 N7016d835fa124626bb066d52523fead0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Receptors, Virus
141 rdf:type schema:DefinedTerm
142 N70876a4a886e4f8886ecf0a6ab8c33a2 rdf:first sg:person.01112263622.40
143 rdf:rest N8e310f7e9c8c4cd0828e7e8f21ee4856
144 N79aeaa46148e43a5ade0cc0b2daf3874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Chromosome Mapping
146 rdf:type schema:DefinedTerm
147 N804957469a564b64b4c968db5ca36341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Carcinoma, Renal Cell
149 rdf:type schema:DefinedTerm
150 N8133b5d869bf40e69ad8ab71df388558 schema:issueNumber 5
151 rdf:type schema:PublicationIssue
152 N8227f20324344afa8575eb879ec524c2 schema:name pubmed_id
153 schema:value 15086915
154 rdf:type schema:PropertyValue
155 N846b8bb9f6394ba1afd1352541aca8f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Cercopithecus aethiops
157 rdf:type schema:DefinedTerm
158 N8e310f7e9c8c4cd0828e7e8f21ee4856 rdf:first sg:person.07713025034.84
159 rdf:rest Na044558ab2944764808482a38b99cca5
160 N8fddece2abd147c89d278c69897b5930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Female
162 rdf:type schema:DefinedTerm
163 N986b464cec4b4d758fda526d3f12e52d schema:name nlm_unique_id
164 schema:value 0323470
165 rdf:type schema:PropertyValue
166 Na044558ab2944764808482a38b99cca5 rdf:first Nf0b4073a1ba54b46b442922410e5c534
167 rdf:rest N61bdffe19b634e23aa73724e368999bb
168 Na2cc54f9f6c243619a415efca33540af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Chromosomes, Human, Pair 5
170 rdf:type schema:DefinedTerm
171 Na7a6cd4d6967482386019ce9c545c87e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Humans
173 rdf:type schema:DefinedTerm
174 Nb36a2a18d43b44bca2af1774702f0435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Kidney Neoplasms
176 rdf:type schema:DefinedTerm
177 Nb448240867694fcba9939cec1b00e59d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Cell Differentiation
179 rdf:type schema:DefinedTerm
180 Nb7fb76c7e06941bcbacc0136a7fb1fa8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name RNA, Neoplasm
182 rdf:type schema:DefinedTerm
183 Nbaac2e285305484c88d14fee7a0d757b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Gene Expression
185 rdf:type schema:DefinedTerm
186 Nc7bfed36c6994a3a8566dac9c9a06cf2 rdf:first sg:person.01177377426.45
187 rdf:rest rdf:nil
188 Ncf51de041d3b4ca58bcc6945f0281037 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cell Division
190 rdf:type schema:DefinedTerm
191 Nd7e0d63280c9435cbbafad97319be517 schema:name dimensions_id
192 schema:value pub.1017166225
193 rdf:type schema:PropertyValue
194 Nd84ba915913843f6b8432d4903fa28d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Polymerase Chain Reaction
196 rdf:type schema:DefinedTerm
197 Ndad0b32625aa4bee95bf3bc593e00217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Membrane Glycoproteins
199 rdf:type schema:DefinedTerm
200 Nde5ead5f5e134a7f92d3327c1283fe15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Cell Line, Tumor
202 rdf:type schema:DefinedTerm
203 Ne9f9961f7d4f45028fbef5e3181dce8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name DNA, Neoplasm
205 rdf:type schema:DefinedTerm
206 Nebe4397475ad4ef9a7daa0d2020472a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Middle Aged
208 rdf:type schema:DefinedTerm
209 Nf0b4073a1ba54b46b442922410e5c534 schema:familyName Porta
210 schema:givenName Ruth
211 rdf:type schema:Person
212 Nf0b6a3651c8a4a39a6fe5cf49a17e97a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Male
214 rdf:type schema:DefinedTerm
215 Nf474a0496450434abc4a2748e35d8626 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Hepatitis A Virus Cellular Receptor 1
217 rdf:type schema:DefinedTerm
218 Nf9595ca9cda4406e968b0ccf6836f84f rdf:first sg:person.0770473436.67
219 rdf:rest N70876a4a886e4f8886ecf0a6ab8c33a2
220 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
221 schema:name Medical and Health Sciences
222 rdf:type schema:DefinedTerm
223 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
224 schema:name Clinical Sciences
225 rdf:type schema:DefinedTerm
226 sg:journal.1015319 schema:issn 0085-2538
227 1523-1755
228 schema:name Kidney International
229 rdf:type schema:Periodical
230 sg:person.01001563417.79 schema:familyName Kaplan
231 schema:givenName Gerardo G
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001563417.79
233 rdf:type schema:Person
234 sg:person.01112263622.40 schema:familyName Nadal
235 schema:givenName Margarita
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112263622.40
237 rdf:type schema:Person
238 sg:person.01174264563.01 schema:familyName Bellmunt
239 schema:givenName Joaquim
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174264563.01
241 rdf:type schema:Person
242 sg:person.01177377426.45 schema:familyName Meseguer
243 schema:givenName Anna
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177377426.45
245 rdf:type schema:Person
246 sg:person.013207107432.21 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
247 schema:familyName Vilà
248 schema:givenName Maya R
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013207107432.21
250 rdf:type schema:Person
251 sg:person.0770473436.67 schema:familyName Feigelstock
252 schema:givenName Dino
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770473436.67
254 rdf:type schema:Person
255 sg:person.07713025034.84 schema:familyName Morote
256 schema:givenName Joan
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07713025034.84
258 rdf:type schema:Person
259 sg:pub.10.1007/bf00451467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016698310
260 https://doi.org/10.1007/bf00451467
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s001200050311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041092433
263 https://doi.org/10.1007/s001200050311
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/ki.1994.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044350397
266 https://doi.org/10.1038/ki.1994.6
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/ni739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040568109
269 https://doi.org/10.1038/ni739
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nrc779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007964460
272 https://doi.org/10.1038/nrc779
273 rdf:type schema:CreativeWork
274 sg:pub.10.1046/j.1523-1755.2002.00433.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005473484
275 https://doi.org/10.1046/j.1523-1755.2002.00433.x
276 rdf:type schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1064243691 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1074814434 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1078472116 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1079236979 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1079410921 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1079698281 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1082424614 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1082424621 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1082711213 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1082737210 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1082787100 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1082842695 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1082958854 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1083288885 schema:CreativeWork
291 https://doi.org/10.1002/(sici)1097-0215(19980504)76:3<337::aid-ijc9>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1008165728
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1002/1097-0142(20000701)89:1<152::aid-cncr20>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1022056299
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1002/j.1460-2075.1996.tb00803.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082979352
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1006/abio.1987.9999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054484911
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/0003-2697(87)90021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321498
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/0076-6879(95)54020-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014409014
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/0165-4608(86)90066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006140152
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/0169-5002(89)90356-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009394364
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0002-9440(10)65349-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042585483
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s0022-5347(05)67892-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011414145
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s0022-5347(17)48932-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079428168
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1073/pnas.171209998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006597771
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1073/pnas.96.10.5400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031332428
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1074/jbc.273.7.4135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044428091
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/jbc.m200562200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026976729
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1083/jcb.111.5.2097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049618726
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1083/jcb.129.1.255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008578038
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/nar/20.19.4965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040951474
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1097/00042307-200109000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013637842
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1128/mcb.18.1.576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026625324
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1136/jmg.34.1.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051066833
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1159/000056987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048480256
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1210/endo.139.2.5763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282179
336 rdf:type schema:CreativeWork
337 https://www.grid.ac/institutes/grid.411083.f schema:alternateName Hospital Universitari Vall d'Hebron
338 schema:name Centre d'Investigacions en Bioquímica i Biologia Molecular (CIBBIM), Hospital Universitari Vall d'Hebron, Barcelona. Spain.
339 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...